Roles of acid/base nature and molecular weight in drug release from matrices of gelfoam and monoisopropyl ester of poly(vinyl methyl ether–maleic anhydride)
Ophthalmic drug inserts are usually placed in the conjunctival sac. Being in contact with the conjunctiva, they may provide means to deliver large and hydrophilic molecules, such as peptides and oligonucleotides into the eye. We evaluated Gelfoam and monoisopropyl ester of poly(vinyl methyl ether/ma...
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| Veröffentlicht in: | Journal of controlled release 1998-12, Vol.56 (1), p.273-283 |
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| creator | Hämäläinen, Kaisa Mari Määttä, Elsi Piirainen, Hilkka Marianne Sarkola Väisänen, Anne Ranta, Veli-Pekka Urtti, Arto |
| description | Ophthalmic drug inserts are usually placed in the conjunctival sac. Being in contact with the conjunctiva, they may provide means to deliver large and hydrophilic molecules, such as peptides and oligonucleotides into the eye. We evaluated Gelfoam and monoisopropyl ester of poly(vinyl methyl ether/maleic anhydride) (PVM/MA) as potential polymers for ocular inserts. Matrices were solvent cast with model drugs that had different p
K
a, molecular weight and hydrophilicity. Drug release from the matrices as well as charge and swelling of Gelfoam®-matrix were studied. The release of drugs from PVM/MA-matrices was by erosion of the polymer matrix. The molecular weight and other variants of the releasing compound did not affect their release. In Gelfoam®-matrices the release was diffusion controlled and it was affected by the pH of the external solution as well as the charge and molecular weight of the studied compound. |
| doi_str_mv | 10.1016/S0168-3659(98)00094-7 |
| format | Article |
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K
a, molecular weight and hydrophilicity. Drug release from the matrices as well as charge and swelling of Gelfoam®-matrix were studied. The release of drugs from PVM/MA-matrices was by erosion of the polymer matrix. The molecular weight and other variants of the releasing compound did not affect their release. In Gelfoam®-matrices the release was diffusion controlled and it was affected by the pH of the external solution as well as the charge and molecular weight of the studied compound.</description><identifier>ISSN: 0168-3659</identifier><identifier>EISSN: 1873-4995</identifier><identifier>DOI: 10.1016/S0168-3659(98)00094-7</identifier><identifier>PMID: 9801450</identifier><identifier>CODEN: JCREEC</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject><![CDATA[Biological and medical sciences ; Buffers ; Conjunctiva ; Delayed-Action Preparations ; Dextrans - administration & dosage ; Dextrans - chemistry ; Diffusion ; Drug release ; Esters - administration & dosage ; Esters - chemistry ; Fluorescein-5-isothiocyanate - administration & dosage ; Fluorescein-5-isothiocyanate - analogs & derivatives ; Fluorescein-5-isothiocyanate - chemistry ; Fluoresceins - administration & dosage ; Fluoresceins - chemistry ; Furosemide - administration & dosage ; Furosemide - chemistry ; Gelatin Sponge, Absorbable - administration & dosage ; Gelatin Sponge, Absorbable - chemistry ; Gelfoam ; General pharmacology ; Hydrogen-Ion Concentration ; Maleates - administration & dosage ; Maleates - chemistry ; Mannitol - administration & dosage ; Mannitol - chemistry ; Medical sciences ; Molecular Weight ; Ocular drug delivery ; Ocular insert ; Ophthalmic Solutions ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Poly(vinyl methyl ether–maleic anhydride) ; Polyethylenes - administration & dosage ; Polyethylenes - chemistry ; Polymer erosion ; Sclera ; Timolol - administration & dosage ; Timolol - chemistry]]></subject><ispartof>Journal of controlled release, 1998-12, Vol.56 (1), p.273-283</ispartof><rights>1998 Elsevier Science B.V.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-abc8d9b7e50724ab227f5b49da3267d2c9e2459dac2393251491ea40e45b4b4a3</citedby><cites>FETCH-LOGICAL-c389t-abc8d9b7e50724ab227f5b49da3267d2c9e2459dac2393251491ea40e45b4b4a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0168-3659(98)00094-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1738460$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9801450$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hämäläinen, Kaisa Mari</creatorcontrib><creatorcontrib>Määttä, Elsi</creatorcontrib><creatorcontrib>Piirainen, Hilkka</creatorcontrib><creatorcontrib>Marianne Sarkola</creatorcontrib><creatorcontrib>Väisänen, Anne</creatorcontrib><creatorcontrib>Ranta, Veli-Pekka</creatorcontrib><creatorcontrib>Urtti, Arto</creatorcontrib><title>Roles of acid/base nature and molecular weight in drug release from matrices of gelfoam and monoisopropyl ester of poly(vinyl methyl ether–maleic anhydride)</title><title>Journal of controlled release</title><addtitle>J Control Release</addtitle><description>Ophthalmic drug inserts are usually placed in the conjunctival sac. Being in contact with the conjunctiva, they may provide means to deliver large and hydrophilic molecules, such as peptides and oligonucleotides into the eye. We evaluated Gelfoam and monoisopropyl ester of poly(vinyl methyl ether/maleic anhydride) (PVM/MA) as potential polymers for ocular inserts. Matrices were solvent cast with model drugs that had different p
K
a, molecular weight and hydrophilicity. Drug release from the matrices as well as charge and swelling of Gelfoam®-matrix were studied. The release of drugs from PVM/MA-matrices was by erosion of the polymer matrix. The molecular weight and other variants of the releasing compound did not affect their release. In Gelfoam®-matrices the release was diffusion controlled and it was affected by the pH of the external solution as well as the charge and molecular weight of the studied compound.</description><subject>Biological and medical sciences</subject><subject>Buffers</subject><subject>Conjunctiva</subject><subject>Delayed-Action Preparations</subject><subject>Dextrans - administration & dosage</subject><subject>Dextrans - chemistry</subject><subject>Diffusion</subject><subject>Drug release</subject><subject>Esters - administration & dosage</subject><subject>Esters - chemistry</subject><subject>Fluorescein-5-isothiocyanate - administration & dosage</subject><subject>Fluorescein-5-isothiocyanate - analogs & derivatives</subject><subject>Fluorescein-5-isothiocyanate - chemistry</subject><subject>Fluoresceins - administration & dosage</subject><subject>Fluoresceins - chemistry</subject><subject>Furosemide - administration & dosage</subject><subject>Furosemide - chemistry</subject><subject>Gelatin Sponge, Absorbable - administration & dosage</subject><subject>Gelatin Sponge, Absorbable - chemistry</subject><subject>Gelfoam</subject><subject>General pharmacology</subject><subject>Hydrogen-Ion Concentration</subject><subject>Maleates - administration & dosage</subject><subject>Maleates - chemistry</subject><subject>Mannitol - administration & dosage</subject><subject>Mannitol - chemistry</subject><subject>Medical sciences</subject><subject>Molecular Weight</subject><subject>Ocular drug delivery</subject><subject>Ocular insert</subject><subject>Ophthalmic Solutions</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Poly(vinyl methyl ether–maleic anhydride)</subject><subject>Polyethylenes - administration & dosage</subject><subject>Polyethylenes - chemistry</subject><subject>Polymer erosion</subject><subject>Sclera</subject><subject>Timolol - administration & dosage</subject><subject>Timolol - chemistry</subject><issn>0168-3659</issn><issn>1873-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxi0EKkvhESr5gFB7CHUcZ22fEKqgIFVC4s_ZmtiTXSMnXuykaG-8A3cerk-C012VIxdb9vf7ZkbzEXJWs9c1q9eXX8qhqmbd6nOtLhhjWlTyEVnVSjaV0Lp9TFYPyFPyLOfvBWobIU_IiVasFi1bkT-fY8BMY0_BenfZQUY6wjQnpDA6OhTVzgES_Yl-s52oH6lL84YmDLiwfYoDHWBK3h7KbDD0EYaje4w-x12Ku32gmCdMC7KLYX9-68fyN-C0XaRpi-nu1-8BAnpbvNu9S97hxXPypIeQ8cXxPiXf3r_7evWhuvl0_fHq7U1lG6WnCjqrnO4ktkxyAR3nsm87oR00fC0dtxq5aMvT8kY3vK2FrhEEQ1GoTkBzSl4d6pZZf8xlUjP4bDEEGDHO2UjGuFKKF7A9gDbFnBP2Zpf8AGlvamaWXMx9LmZZutHK3OdiZPGdHRvM3YDuwXUMougvjzpkC6FPMFqf_xWXjRLrBXtzwLAs49ZjMtl6HC06n9BOxkX_n0H-Ag97rfM</recordid><startdate>19981204</startdate><enddate>19981204</enddate><creator>Hämäläinen, Kaisa Mari</creator><creator>Määttä, Elsi</creator><creator>Piirainen, Hilkka</creator><creator>Marianne Sarkola</creator><creator>Väisänen, Anne</creator><creator>Ranta, Veli-Pekka</creator><creator>Urtti, Arto</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19981204</creationdate><title>Roles of acid/base nature and molecular weight in drug release from matrices of gelfoam and monoisopropyl ester of poly(vinyl methyl ether–maleic anhydride)</title><author>Hämäläinen, Kaisa Mari ; Määttä, Elsi ; Piirainen, Hilkka ; Marianne Sarkola ; Väisänen, Anne ; Ranta, Veli-Pekka ; Urtti, Arto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-abc8d9b7e50724ab227f5b49da3267d2c9e2459dac2393251491ea40e45b4b4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Biological and medical sciences</topic><topic>Buffers</topic><topic>Conjunctiva</topic><topic>Delayed-Action Preparations</topic><topic>Dextrans - administration & dosage</topic><topic>Dextrans - chemistry</topic><topic>Diffusion</topic><topic>Drug release</topic><topic>Esters - administration & dosage</topic><topic>Esters - chemistry</topic><topic>Fluorescein-5-isothiocyanate - administration & dosage</topic><topic>Fluorescein-5-isothiocyanate - analogs & derivatives</topic><topic>Fluorescein-5-isothiocyanate - chemistry</topic><topic>Fluoresceins - administration & dosage</topic><topic>Fluoresceins - chemistry</topic><topic>Furosemide - administration & dosage</topic><topic>Furosemide - chemistry</topic><topic>Gelatin Sponge, Absorbable - administration & dosage</topic><topic>Gelatin Sponge, Absorbable - chemistry</topic><topic>Gelfoam</topic><topic>General pharmacology</topic><topic>Hydrogen-Ion Concentration</topic><topic>Maleates - administration & dosage</topic><topic>Maleates - chemistry</topic><topic>Mannitol - administration & dosage</topic><topic>Mannitol - chemistry</topic><topic>Medical sciences</topic><topic>Molecular Weight</topic><topic>Ocular drug delivery</topic><topic>Ocular insert</topic><topic>Ophthalmic Solutions</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Poly(vinyl methyl ether–maleic anhydride)</topic><topic>Polyethylenes - administration & dosage</topic><topic>Polyethylenes - chemistry</topic><topic>Polymer erosion</topic><topic>Sclera</topic><topic>Timolol - administration & dosage</topic><topic>Timolol - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hämäläinen, Kaisa Mari</creatorcontrib><creatorcontrib>Määttä, Elsi</creatorcontrib><creatorcontrib>Piirainen, Hilkka</creatorcontrib><creatorcontrib>Marianne Sarkola</creatorcontrib><creatorcontrib>Väisänen, Anne</creatorcontrib><creatorcontrib>Ranta, Veli-Pekka</creatorcontrib><creatorcontrib>Urtti, Arto</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of controlled release</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hämäläinen, Kaisa Mari</au><au>Määttä, Elsi</au><au>Piirainen, Hilkka</au><au>Marianne Sarkola</au><au>Väisänen, Anne</au><au>Ranta, Veli-Pekka</au><au>Urtti, Arto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Roles of acid/base nature and molecular weight in drug release from matrices of gelfoam and monoisopropyl ester of poly(vinyl methyl ether–maleic anhydride)</atitle><jtitle>Journal of controlled release</jtitle><addtitle>J Control Release</addtitle><date>1998-12-04</date><risdate>1998</risdate><volume>56</volume><issue>1</issue><spage>273</spage><epage>283</epage><pages>273-283</pages><issn>0168-3659</issn><eissn>1873-4995</eissn><coden>JCREEC</coden><abstract>Ophthalmic drug inserts are usually placed in the conjunctival sac. Being in contact with the conjunctiva, they may provide means to deliver large and hydrophilic molecules, such as peptides and oligonucleotides into the eye. We evaluated Gelfoam and monoisopropyl ester of poly(vinyl methyl ether/maleic anhydride) (PVM/MA) as potential polymers for ocular inserts. Matrices were solvent cast with model drugs that had different p
K
a, molecular weight and hydrophilicity. Drug release from the matrices as well as charge and swelling of Gelfoam®-matrix were studied. The release of drugs from PVM/MA-matrices was by erosion of the polymer matrix. The molecular weight and other variants of the releasing compound did not affect their release. In Gelfoam®-matrices the release was diffusion controlled and it was affected by the pH of the external solution as well as the charge and molecular weight of the studied compound.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>9801450</pmid><doi>10.1016/S0168-3659(98)00094-7</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0168-3659 |
| ispartof | Journal of controlled release, 1998-12, Vol.56 (1), p.273-283 |
| issn | 0168-3659 1873-4995 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70028882 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Biological and medical sciences Buffers Conjunctiva Delayed-Action Preparations Dextrans - administration & dosage Dextrans - chemistry Diffusion Drug release Esters - administration & dosage Esters - chemistry Fluorescein-5-isothiocyanate - administration & dosage Fluorescein-5-isothiocyanate - analogs & derivatives Fluorescein-5-isothiocyanate - chemistry Fluoresceins - administration & dosage Fluoresceins - chemistry Furosemide - administration & dosage Furosemide - chemistry Gelatin Sponge, Absorbable - administration & dosage Gelatin Sponge, Absorbable - chemistry Gelfoam General pharmacology Hydrogen-Ion Concentration Maleates - administration & dosage Maleates - chemistry Mannitol - administration & dosage Mannitol - chemistry Medical sciences Molecular Weight Ocular drug delivery Ocular insert Ophthalmic Solutions Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Poly(vinyl methyl ether–maleic anhydride) Polyethylenes - administration & dosage Polyethylenes - chemistry Polymer erosion Sclera Timolol - administration & dosage Timolol - chemistry |
| title | Roles of acid/base nature and molecular weight in drug release from matrices of gelfoam and monoisopropyl ester of poly(vinyl methyl ether–maleic anhydride) |
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