Uptake of cationic technetium complexes in cultured human carcinoma cells and human xenografts

We evaluated lipophilicity, in vitro cell accumulation, and biodistribution of a series of 99mTc-ether isonitrile complexes to determine whether increased lipophilicity promotes extraction by tumor or enhances imaging properties of the radiopharmaceutical. Nine 99mTc-sestamibi analogs were synthesiz...

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Veröffentlicht in:	Nuclear medicine and biology 1998-10, Vol.25 (7), p.667-673
Hauptverfasser:	Barbarics, Eva, Kronauge, James F., Davison, Alan, Jones, Alun G.
Format:	Artikel
Sprache:	eng
Schlagworte:	99mTc-EIBI 99mTc-Ether isonitriles 99mTc-MIBI Animals Biological and medical sciences Breast Neoplasms - chemistry Cations - metabolism Colonic Neoplasms - chemistry Contrast media. Radiopharmaceuticals Female Human carcinoma cell lines Human xenograft Humans Lung Neoplasms - chemistry Medical sciences Mice Mice, Nude Neoplasm Transplantation Nitriles - chemistry Pharmacology. Drug treatments Subrenal Capsule Assay Technetium Compounds - chemistry Technetium Compounds - metabolism Technetium Compounds - pharmacokinetics Technetium Tc 99m Sestamibi - analogs & derivatives Technetium Tc 99m Sestamibi - chemistry Tissue Distribution Tumor Cells, Cultured
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