Low Humidity Stimulates Epidermal DNA Synthesis and Amplifies the Hyperproliferative Response to Barrier Disruption: Implication for Seasonal Exacerbations of Inflammatory Dermatoses

Although seasonal changes in humidity are thought to exacerbate various skin diseases, whether these flares can be attributed to prolonged exposure to extremes in environmental humidities has not been studied systematically. We recently showed that prolonged exposure to high versus low humidities in...

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Veröffentlicht in:	Journal of investigative dermatology 1998-11, Vol.111 (5), p.873-878
Hauptverfasser:	Denda, Mitsuhiro, Sato, Junko, Tsuchiya, Toru, Elias, Peter M., Feingold, Kenneth R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetone - pharmacology Animals Biological and medical sciences Cell Degranulation Cell Division - physiology Cell Membrane Permeability - drug effects Cell Membrane Permeability - physiology Dermatitis - physiopathology Dermatology DNA - biosynthesis dry environment humectant Humidity mast cell occlusion Mast Cells - cytology Medical sciences Mice Mice, Hairless Seasons Skin - cytology Skin - metabolism Skin involvement in other diseases. Miscellaneous. General aspects Time Factors
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