Pax6 induces ectopic eyes in a vertebrate

We report here that misexpression of the transcription factor Pax6 in the vertebrate Xenopus laevis leads to the formation of differentiated ectopic eyes. Multiple molecular markers indicated the presence of mature lens fiber cells, ganglion cells, Muller cells, photoreceptors and retinal pigment ep...

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Veröffentlicht in:	Development (Cambridge) 1999-10, Vol.126 (19), p.4213-4222
Hauptverfasser:	Chow, R L, Altmann, C R, Lang, R A, Hemmati-Brivanlou, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Choristoma Cloning, Molecular DNA-Binding Proteins - physiology Embryo, Nonmammalian - metabolism Eye - anatomy & histology Eye - embryology Eye Abnormalities - genetics Eye Proteins Gene Expression Regulation, Developmental Genes, Dominant Homeodomain Proteins In Situ Hybridization Lens, Crystalline - anatomy & histology Lens, Crystalline - embryology Otx2 gene Paired Box Transcription Factors Pax6 gene Pax6 protein PAX6 Transcription Factor Phenotype Repressor Proteins Retina - anatomy & histology Retina - embryology Reverse Transcriptase Polymerase Chain Reaction Rx gene Six3 gene Xenopus Xenopus laevis - embryology Xenopus laevis - genetics
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