Skeletal muscle vasodilation at the onset of exercise
Departments of Anesthesiology and Physiology, Medical College of Wisconsin and Veterans Affairs Medical Center, Milwaukee, Wisconsin 53295 The purpose of this study was to determine whether -adrenergic or muscarinic receptors are involved in skeletal muscle vasodilation at the onset of exercise. Mon...
Gespeichert in:
| Veröffentlicht in: | Journal of applied physiology (1985) 1998-11, Vol.85 (5), p.1649-1654 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1654 |
|---|---|
| container_issue | 5 |
| container_start_page | 1649 |
| container_title | Journal of applied physiology (1985) |
| container_volume | 85 |
| creator | Buckwalter, John B Ruble, Stephen B Mueller, Patrick J Clifford, Philip S |
| description | Departments of Anesthesiology and Physiology, Medical College of
Wisconsin and Veterans Affairs Medical Center, Milwaukee, Wisconsin
53295
The purpose of this study was to determine
whether -adrenergic or muscarinic receptors are involved in skeletal
muscle vasodilation at the onset of exercise. Mongrel dogs
( n = 7) were instrumented with flow probes on both external
iliac arteries and a catheter in one femoral artery. Propranolol (1 mg), atropine (500 µg), both drugs, or saline was infused
intra-arterially immediately before treadmill exercise at 3 miles/h,
0% grade. Immediate and rapid increases in iliac blood flow occurred
with initiation of exercise under all conditions. Peak blood flows were
not significantly different among conditions (682 ± 35, 646 ± 49, 637 ± 68, and 705 ± 50 ml/min, respectively). Although the
doses of antagonists employed had no effect on heart rate or systemic
blood pressure, they were adequate to abolish agonist-induced increases
in iliac blood flow. Because neither propranolol nor atropine affected iliac blood flow, we conclude that activation of -adrenergic and
muscarinic receptors is not essential for the rapid vasodilation in
active skeletal muscle at the onset of exercise in dogs.
blood flow; autonomic nervous system; muscarinic; -adrenergic; dogs |
| doi_str_mv | 10.1152/jappl.1998.85.5.1649 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70027400</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70027400</sourcerecordid><originalsourceid>FETCH-LOGICAL-c467t-50d4175b531fdafb554309bdaca8340f36c2ad3d833f77c03b62c712afd9f9553</originalsourceid><addsrcrecordid>eNqFkMtO3DAUhq2qFR0ub9BKUYUQm6R27BM7ywpBi4TEArq2HF-YTD1xaieFeXs8ZQQIqao3XvyXc86H0CeCK0Kg_rpS4-gr0raiElBBRRrWvkOLLNUlaTB5jxaCAy45CP4R7ae0wpgwBmQP7bUCM2hggeDml_V2Ur5Yz0l7W_xRKZjeq6kPQ6GmYlraIgzJTkVwhX2wUffJHqIPTvlkj3b_Afp5cX579qO8uv5-efbtqtSs4VMJ2DDCoQNKnFGuA2AUt51RWgnKsKONrpWhRlDqONeYdk2tOamVM61rAegBOnnqHWP4Pds0yXWftPVeDTbMSXKMa84w_q-RCME5bZts_PLGuApzHPIRss4PE85YNrEnk44hpWidHGO_VnEjCZZb9vIve7llLwVIkFv2OfZ51z13a2ueQzvYWT_e6Spp5V1UQ4b50t1QQRi8TF_2d8v7Plo5LjepDz7cbeTF7P2tfZi2GzxPlqNxOXb671h2v1r0EU6HrWs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>222201744</pqid></control><display><type>article</type><title>Skeletal muscle vasodilation at the onset of exercise</title><source>MEDLINE</source><source>American Physiological Society</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Buckwalter, John B ; Ruble, Stephen B ; Mueller, Patrick J ; Clifford, Philip S</creator><creatorcontrib>Buckwalter, John B ; Ruble, Stephen B ; Mueller, Patrick J ; Clifford, Philip S</creatorcontrib><description>Departments of Anesthesiology and Physiology, Medical College of
Wisconsin and Veterans Affairs Medical Center, Milwaukee, Wisconsin
53295
The purpose of this study was to determine
whether -adrenergic or muscarinic receptors are involved in skeletal
muscle vasodilation at the onset of exercise. Mongrel dogs
( n = 7) were instrumented with flow probes on both external
iliac arteries and a catheter in one femoral artery. Propranolol (1 mg), atropine (500 µg), both drugs, or saline was infused
intra-arterially immediately before treadmill exercise at 3 miles/h,
0% grade. Immediate and rapid increases in iliac blood flow occurred
with initiation of exercise under all conditions. Peak blood flows were
not significantly different among conditions (682 ± 35, 646 ± 49, 637 ± 68, and 705 ± 50 ml/min, respectively). Although the
doses of antagonists employed had no effect on heart rate or systemic
blood pressure, they were adequate to abolish agonist-induced increases
in iliac blood flow. Because neither propranolol nor atropine affected iliac blood flow, we conclude that activation of -adrenergic and
muscarinic receptors is not essential for the rapid vasodilation in
active skeletal muscle at the onset of exercise in dogs.
blood flow; autonomic nervous system; muscarinic; -adrenergic; dogs</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.1998.85.5.1649</identifier><identifier>PMID: 9804565</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Adrenergic beta-Antagonists - pharmacology ; Animals ; Atropine - pharmacology ; Biological and medical sciences ; Blood ; Blood Pressure - physiology ; Dogs ; Exercise ; Fundamental and applied biological sciences. Psychology ; Heart Rate - physiology ; Hindlimb - blood supply ; Muscarinic Agonists - pharmacology ; Muscle, Skeletal - blood supply ; Muscle, Skeletal - physiology ; Muscular system ; Physical Exertion - physiology ; Propranolol - pharmacology ; Regional Blood Flow - physiology ; Space life sciences ; Striated muscle. Tendons ; Vasodilation - physiology ; Vertebrates: osteoarticular system, musculoskeletal system</subject><ispartof>Journal of applied physiology (1985), 1998-11, Vol.85 (5), p.1649-1654</ispartof><rights>1999 INIST-CNRS</rights><rights>Copyright American Physiological Society Nov 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-50d4175b531fdafb554309bdaca8340f36c2ad3d833f77c03b62c712afd9f9553</citedby><cites>FETCH-LOGICAL-c467t-50d4175b531fdafb554309bdaca8340f36c2ad3d833f77c03b62c712afd9f9553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,3026,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1638145$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9804565$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buckwalter, John B</creatorcontrib><creatorcontrib>Ruble, Stephen B</creatorcontrib><creatorcontrib>Mueller, Patrick J</creatorcontrib><creatorcontrib>Clifford, Philip S</creatorcontrib><title>Skeletal muscle vasodilation at the onset of exercise</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>Departments of Anesthesiology and Physiology, Medical College of
Wisconsin and Veterans Affairs Medical Center, Milwaukee, Wisconsin
53295
The purpose of this study was to determine
whether -adrenergic or muscarinic receptors are involved in skeletal
muscle vasodilation at the onset of exercise. Mongrel dogs
( n = 7) were instrumented with flow probes on both external
iliac arteries and a catheter in one femoral artery. Propranolol (1 mg), atropine (500 µg), both drugs, or saline was infused
intra-arterially immediately before treadmill exercise at 3 miles/h,
0% grade. Immediate and rapid increases in iliac blood flow occurred
with initiation of exercise under all conditions. Peak blood flows were
not significantly different among conditions (682 ± 35, 646 ± 49, 637 ± 68, and 705 ± 50 ml/min, respectively). Although the
doses of antagonists employed had no effect on heart rate or systemic
blood pressure, they were adequate to abolish agonist-induced increases
in iliac blood flow. Because neither propranolol nor atropine affected iliac blood flow, we conclude that activation of -adrenergic and
muscarinic receptors is not essential for the rapid vasodilation in
active skeletal muscle at the onset of exercise in dogs.
blood flow; autonomic nervous system; muscarinic; -adrenergic; dogs</description><subject>Adrenergic beta-Antagonists - pharmacology</subject><subject>Animals</subject><subject>Atropine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Blood Pressure - physiology</subject><subject>Dogs</subject><subject>Exercise</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart Rate - physiology</subject><subject>Hindlimb - blood supply</subject><subject>Muscarinic Agonists - pharmacology</subject><subject>Muscle, Skeletal - blood supply</subject><subject>Muscle, Skeletal - physiology</subject><subject>Muscular system</subject><subject>Physical Exertion - physiology</subject><subject>Propranolol - pharmacology</subject><subject>Regional Blood Flow - physiology</subject><subject>Space life sciences</subject><subject>Striated muscle. Tendons</subject><subject>Vasodilation - physiology</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtO3DAUhq2qFR0ub9BKUYUQm6R27BM7ywpBi4TEArq2HF-YTD1xaieFeXs8ZQQIqao3XvyXc86H0CeCK0Kg_rpS4-gr0raiElBBRRrWvkOLLNUlaTB5jxaCAy45CP4R7ae0wpgwBmQP7bUCM2hggeDml_V2Ur5Yz0l7W_xRKZjeq6kPQ6GmYlraIgzJTkVwhX2wUffJHqIPTvlkj3b_Afp5cX579qO8uv5-efbtqtSs4VMJ2DDCoQNKnFGuA2AUt51RWgnKsKONrpWhRlDqONeYdk2tOamVM61rAegBOnnqHWP4Pds0yXWftPVeDTbMSXKMa84w_q-RCME5bZts_PLGuApzHPIRss4PE85YNrEnk44hpWidHGO_VnEjCZZb9vIve7llLwVIkFv2OfZ51z13a2ueQzvYWT_e6Spp5V1UQ4b50t1QQRi8TF_2d8v7Plo5LjepDz7cbeTF7P2tfZi2GzxPlqNxOXb671h2v1r0EU6HrWs</recordid><startdate>19981101</startdate><enddate>19981101</enddate><creator>Buckwalter, John B</creator><creator>Ruble, Stephen B</creator><creator>Mueller, Patrick J</creator><creator>Clifford, Philip S</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19981101</creationdate><title>Skeletal muscle vasodilation at the onset of exercise</title><author>Buckwalter, John B ; Ruble, Stephen B ; Mueller, Patrick J ; Clifford, Philip S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-50d4175b531fdafb554309bdaca8340f36c2ad3d833f77c03b62c712afd9f9553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adrenergic beta-Antagonists - pharmacology</topic><topic>Animals</topic><topic>Atropine - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Blood Pressure - physiology</topic><topic>Dogs</topic><topic>Exercise</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart Rate - physiology</topic><topic>Hindlimb - blood supply</topic><topic>Muscarinic Agonists - pharmacology</topic><topic>Muscle, Skeletal - blood supply</topic><topic>Muscle, Skeletal - physiology</topic><topic>Muscular system</topic><topic>Physical Exertion - physiology</topic><topic>Propranolol - pharmacology</topic><topic>Regional Blood Flow - physiology</topic><topic>Space life sciences</topic><topic>Striated muscle. Tendons</topic><topic>Vasodilation - physiology</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buckwalter, John B</creatorcontrib><creatorcontrib>Ruble, Stephen B</creatorcontrib><creatorcontrib>Mueller, Patrick J</creatorcontrib><creatorcontrib>Clifford, Philip S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buckwalter, John B</au><au>Ruble, Stephen B</au><au>Mueller, Patrick J</au><au>Clifford, Philip S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Skeletal muscle vasodilation at the onset of exercise</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>1998-11-01</date><risdate>1998</risdate><volume>85</volume><issue>5</issue><spage>1649</spage><epage>1654</epage><pages>1649-1654</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>Departments of Anesthesiology and Physiology, Medical College of
Wisconsin and Veterans Affairs Medical Center, Milwaukee, Wisconsin
53295
The purpose of this study was to determine
whether -adrenergic or muscarinic receptors are involved in skeletal
muscle vasodilation at the onset of exercise. Mongrel dogs
( n = 7) were instrumented with flow probes on both external
iliac arteries and a catheter in one femoral artery. Propranolol (1 mg), atropine (500 µg), both drugs, or saline was infused
intra-arterially immediately before treadmill exercise at 3 miles/h,
0% grade. Immediate and rapid increases in iliac blood flow occurred
with initiation of exercise under all conditions. Peak blood flows were
not significantly different among conditions (682 ± 35, 646 ± 49, 637 ± 68, and 705 ± 50 ml/min, respectively). Although the
doses of antagonists employed had no effect on heart rate or systemic
blood pressure, they were adequate to abolish agonist-induced increases
in iliac blood flow. Because neither propranolol nor atropine affected iliac blood flow, we conclude that activation of -adrenergic and
muscarinic receptors is not essential for the rapid vasodilation in
active skeletal muscle at the onset of exercise in dogs.
blood flow; autonomic nervous system; muscarinic; -adrenergic; dogs</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>9804565</pmid><doi>10.1152/jappl.1998.85.5.1649</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8750-7587 |
| ispartof | Journal of applied physiology (1985), 1998-11, Vol.85 (5), p.1649-1654 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70027400 |
| source | MEDLINE; American Physiological Society; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adrenergic beta-Antagonists - pharmacology Animals Atropine - pharmacology Biological and medical sciences Blood Blood Pressure - physiology Dogs Exercise Fundamental and applied biological sciences. Psychology Heart Rate - physiology Hindlimb - blood supply Muscarinic Agonists - pharmacology Muscle, Skeletal - blood supply Muscle, Skeletal - physiology Muscular system Physical Exertion - physiology Propranolol - pharmacology Regional Blood Flow - physiology Space life sciences Striated muscle. Tendons Vasodilation - physiology Vertebrates: osteoarticular system, musculoskeletal system |
| title | Skeletal muscle vasodilation at the onset of exercise |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T03%3A47%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Skeletal%20muscle%20vasodilation%20at%20the%20onset%20of%20exercise&rft.jtitle=Journal%20of%20applied%20physiology%20(1985)&rft.au=Buckwalter,%20John%20B&rft.date=1998-11-01&rft.volume=85&rft.issue=5&rft.spage=1649&rft.epage=1654&rft.pages=1649-1654&rft.issn=8750-7587&rft.eissn=1522-1601&rft.coden=JAPHEV&rft_id=info:doi/10.1152/jappl.1998.85.5.1649&rft_dat=%3Cproquest_cross%3E70027400%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=222201744&rft_id=info:pmid/9804565&rfr_iscdi=true |