Characteristic Change of Urinary Elastin Peptides and Desmosine in the Aortic Aneurysm
To estimate elastin metabolism in aneurysm, urinary levels of desmosine and elastin peptide in patients (n=23, range 54 to 85 years old) with aneurysm were measured by ELISA and compared between two control groups divided by age (20 years old). The amounts of urinary desmosine and elastin peptide in...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 1999/08/15, Vol.22(8), pp.854-857 |
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| container_title | Biological & pharmaceutical bulletin |
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| creator | OSAKABE, Toru USAMI, Eiji SATO, Akira SASAKI, Shigeru WATANABE, Tetsuo SEYAMA, Yoshiyuki |
| description | To estimate elastin metabolism in aneurysm, urinary levels of desmosine and elastin peptide in patients (n=23, range 54 to 85 years old) with aneurysm were measured by ELISA and compared between two control groups divided by age (20 years old). The amounts of urinary desmosine and elastin peptide in the aneurysm group were significantly increased compared with those in the order control group ( |
| doi_str_mv | 10.1248/bpb.22.854 |
| format | Article |
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The amounts of urinary desmosine and elastin peptide in the aneurysm group were significantly increased compared with those in the order control group (<20 years old). There was a correlation between urinary desmosine and elastin peptide in the young group. On the other hand, no such correlation was observed in the aneurysm group and the older control group. The distribution of the ratio (desmosine/elastin peptide) in the aneurysm group was different from that of the young control group. We conclude that assay of elastin peptide and desmosine in urine are useful in characterizing elastin degradation in a patient with aneurysm.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.22.854</identifier><identifier>PMID: 10480325</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Adult ; Aged ; Aged, 80 and over ; aneurysm ; Aortic Aneurysm - urine ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. 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The amounts of urinary desmosine and elastin peptide in the aneurysm group were significantly increased compared with those in the order control group (<20 years old). There was a correlation between urinary desmosine and elastin peptide in the young group. On the other hand, no such correlation was observed in the aneurysm group and the older control group. The distribution of the ratio (desmosine/elastin peptide) in the aneurysm group was different from that of the young control group. We conclude that assay of elastin peptide and desmosine in urine are useful in characterizing elastin degradation in a patient with aneurysm.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>aneurysm</subject><subject>Aortic Aneurysm - urine</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>desmosine</subject><subject>Desmosine - urine</subject><subject>Diseases of the aorta</subject><subject>Elastin - chemistry</subject><subject>elastin peptide</subject><subject>Humans</subject><subject>Infant</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Peptide Fragments - urine</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1O3DAURi1EVaa0Gx6gsgTqolIG_8bOcjTQUgkJFtCtZTs3kFHiTO1kwdvjkBGturFlfcf3Xh8jdEbJmjKhL93erRlbaymO0IpyoQrJqDxGK1JRXZRU6hP0KaUdIUQRxj-iE0qEJpzJFfq9fbbR-hFim8bW43wMT4CHBj_GNtj4gq87m5OA72E_tjUkbEONryD1Q2oD4JyMz4A3Q5yvbwJM8SX1n9GHxnYJvhz2U_T44_phe1Pc3v38td3cFr5keiwawWtfVs47UhHhS6m8otp57Zo8Kam95UxVTlPbaME1lGXpayVdxoWtFOWn6NtSdx-HPxOk0fRt8tB1NsAwJaMIYYorncHz_8DdMMWQZzNUiOyJMUEy9X2hfBxSitCYfWz7bMFQYmbXJrs2jJnsOsNfDyUn10P9D7rIzcDFAbDJ266JNvg2_eUqqUs5v2G7YLs02id4z-1stIO5Ja0q_tZ2WXL399Tn_zMQ-Cvg351U</recordid><startdate>19990801</startdate><enddate>19990801</enddate><creator>OSAKABE, Toru</creator><creator>USAMI, Eiji</creator><creator>SATO, Akira</creator><creator>SASAKI, Shigeru</creator><creator>WATANABE, Tetsuo</creator><creator>SEYAMA, Yoshiyuki</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19990801</creationdate><title>Characteristic Change of Urinary Elastin Peptides and Desmosine in the Aortic Aneurysm</title><author>OSAKABE, Toru ; USAMI, Eiji ; SATO, Akira ; SASAKI, Shigeru ; WATANABE, Tetsuo ; SEYAMA, Yoshiyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c628t-f43dc69bcb0904c657c718bc8bf7020dca3279b81af8438e666cd75bb094a9713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>aneurysm</topic><topic>Aortic Aneurysm - urine</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>desmosine</topic><topic>Desmosine - urine</topic><topic>Diseases of the aorta</topic><topic>Elastin - chemistry</topic><topic>elastin peptide</topic><topic>Humans</topic><topic>Infant</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Peptide Fragments - urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OSAKABE, Toru</creatorcontrib><creatorcontrib>USAMI, Eiji</creatorcontrib><creatorcontrib>SATO, Akira</creatorcontrib><creatorcontrib>SASAKI, Shigeru</creatorcontrib><creatorcontrib>WATANABE, Tetsuo</creatorcontrib><creatorcontrib>SEYAMA, Yoshiyuki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OSAKABE, Toru</au><au>USAMI, Eiji</au><au>SATO, Akira</au><au>SASAKI, Shigeru</au><au>WATANABE, Tetsuo</au><au>SEYAMA, Yoshiyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characteristic Change of Urinary Elastin Peptides and Desmosine in the Aortic Aneurysm</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>1999-08-01</date><risdate>1999</risdate><volume>22</volume><issue>8</issue><spage>854</spage><epage>857</epage><pages>854-857</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>To estimate elastin metabolism in aneurysm, urinary levels of desmosine and elastin peptide in patients (n=23, range 54 to 85 years old) with aneurysm were measured by ELISA and compared between two control groups divided by age (<10 years old and >20 years old). 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| subjects | Adult Aged Aged, 80 and over aneurysm Aortic Aneurysm - urine Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Child Child, Preschool desmosine Desmosine - urine Diseases of the aorta Elastin - chemistry elastin peptide Humans Infant Medical sciences Middle Aged Peptide Fragments - urine |
| title | Characteristic Change of Urinary Elastin Peptides and Desmosine in the Aortic Aneurysm |
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