Expression of human blood clotting factor VIII in the mammary gland of transgenic sheep

By targeting the expression of sequences encoding non-milk proteins to the mammary gland of transgenic farm animals, the organ could serve as a 'bioreactor' for producing pharmacologically active proteins on a large scale. Here we report the generation of transgenic sheep bearing a fusion...

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Veröffentlicht in:	Transgenic research 1999-06, Vol.8 (3), p.237-247
Hauptverfasser:	Niemann, H, Halter, R, Carnwath, J.W, Herrmann, D, Lemme, E, Paul, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified - genetics Animals, Genetically Modified - metabolism Biological and medical sciences Biotechnology coagulation coagulation factor VIII Coagulation factors Factor VIII - biosynthesis Factor VIII - genetics Factor VIII - isolation & purification Female Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry Humans Immunoblotting Industrial applications and implications. Economical aspects Lactoglobulins - biosynthesis Lactoglobulins - genetics Mammary Glands, Animal - metabolism Mice Milk Milk - chemistry Precipitin Tests Production of active biomolecules Recombinant Fusion Proteins - biosynthesis Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - isolation & purification Reverse Transcriptase Polymerase Chain Reaction Sheep - genetics Sheep - metabolism transgenic animals
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