A Model of Coccidioidal Meningoencephalitis and Cerebrospinal Vasculitis in the Rabbit
Coccidioidal meningitis is a devastating complication of disseminated coccidioidomycosis. An animal model of this infection could enhance understanding of the pathogenesis of the disease and lead to improvements in therapy. A rabbit model of central nervous system infection simulating human disease...
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| Veröffentlicht in: | The Journal of infectious diseases 1998-10, Vol.178 (4), p.1217-1221 |
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| container_title | The Journal of infectious diseases |
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| creator | Williams, P. L. Sobel, R. A. Sorensen, K. N. Clemons, K. V. Shuer, L. M. Royaltey, S. S. Yao, Y. Pappagianis, D. Lutz, J. E. Reed, C. River, M. E. Lee, B. C. Bhatti, S. U. Stevens, D. A. |
| description | Coccidioidal meningitis is a devastating complication of disseminated coccidioidomycosis. An animal model of this infection could enhance understanding of the pathogenesis of the disease and lead to improvements in therapy. A rabbit model of central nervous system infection simulating human disease was established using a blind cisternal tap technique to inoculate 4 × 103−1 × 106 arthroconidia of Coccidioides immitis into the cisterna magna. Systemic, neurologic, and histopathologic findings of meningitis were observed in all rabbits, but an inoculum of 2 × 104 arthroconidia produced a chronic illness in which meningeal endarteritis obliterans was consistently observed. Serial sampling of cerebrospinal fluid demonstrated an inflammatory response. Growth of C. immitis was demonstrated by quantitative fungal culture from brains and proximal spinal cords. |
| doi_str_mv | 10.1086/515689 |
| format | Article |
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L. ; Sobel, R. A. ; Sorensen, K. N. ; Clemons, K. V. ; Shuer, L. M. ; Royaltey, S. S. ; Yao, Y. ; Pappagianis, D. ; Lutz, J. E. ; Reed, C. ; River, M. E. ; Lee, B. C. ; Bhatti, S. U. ; Stevens, D. A.</creator><creatorcontrib>Williams, P. L. ; Sobel, R. A. ; Sorensen, K. N. ; Clemons, K. V. ; Shuer, L. M. ; Royaltey, S. S. ; Yao, Y. ; Pappagianis, D. ; Lutz, J. E. ; Reed, C. ; River, M. E. ; Lee, B. C. ; Bhatti, S. U. ; Stevens, D. A.</creatorcontrib><description>Coccidioidal meningitis is a devastating complication of disseminated coccidioidomycosis. An animal model of this infection could enhance understanding of the pathogenesis of the disease and lead to improvements in therapy. A rabbit model of central nervous system infection simulating human disease was established using a blind cisternal tap technique to inoculate 4 × 103−1 × 106 arthroconidia of Coccidioides immitis into the cisterna magna. Systemic, neurologic, and histopathologic findings of meningitis were observed in all rabbits, but an inoculum of 2 × 104 arthroconidia produced a chronic illness in which meningeal endarteritis obliterans was consistently observed. Serial sampling of cerebrospinal fluid demonstrated an inflammatory response. Growth of C. immitis was demonstrated by quantitative fungal culture from brains and proximal spinal cords.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/515689</identifier><identifier>PMID: 9806065</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Animal models ; Animals ; Biological and medical sciences ; Central Nervous System - blood supply ; Central Nervous System - microbiology ; Central Nervous System - pathology ; Cerebrospinal fluid ; Coccidioides ; Coccidioidomycosis - cerebrospinal fluid ; Coccidioidomycosis - etiology ; Coccidioidomycosis - pathology ; Concise Comunications ; Disease models ; Disease Models, Animal ; Endarteritis - etiology ; Endarteritis - pathology ; Experimental mycoses and models ; Infections ; Infectious diseases ; Inoculum ; Male ; Medical sciences ; Meningitis ; Meningoencephalitis - etiology ; Meningoencephalitis - pathology ; Mycoses ; Nervous system diseases ; Rabbits ; Spinal cord ; Subarachnoid space</subject><ispartof>The Journal of infectious diseases, 1998-10, Vol.178 (4), p.1217-1221</ispartof><rights>Copyright 1998 Infectious Diseases Society of America</rights><rights>1998 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Oct 1998</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-6a3c978f2697a4d36335292458c26023965611693790b00d959d0adf7f4d0ad63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30117208$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30117208$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2424731$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9806065$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Williams, P. L.</creatorcontrib><creatorcontrib>Sobel, R. A.</creatorcontrib><creatorcontrib>Sorensen, K. N.</creatorcontrib><creatorcontrib>Clemons, K. V.</creatorcontrib><creatorcontrib>Shuer, L. M.</creatorcontrib><creatorcontrib>Royaltey, S. S.</creatorcontrib><creatorcontrib>Yao, Y.</creatorcontrib><creatorcontrib>Pappagianis, D.</creatorcontrib><creatorcontrib>Lutz, J. E.</creatorcontrib><creatorcontrib>Reed, C.</creatorcontrib><creatorcontrib>River, M. E.</creatorcontrib><creatorcontrib>Lee, B. C.</creatorcontrib><creatorcontrib>Bhatti, S. U.</creatorcontrib><creatorcontrib>Stevens, D. A.</creatorcontrib><title>A Model of Coccidioidal Meningoencephalitis and Cerebrospinal Vasculitis in the Rabbit</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><description>Coccidioidal meningitis is a devastating complication of disseminated coccidioidomycosis. An animal model of this infection could enhance understanding of the pathogenesis of the disease and lead to improvements in therapy. A rabbit model of central nervous system infection simulating human disease was established using a blind cisternal tap technique to inoculate 4 × 103−1 × 106 arthroconidia of Coccidioides immitis into the cisterna magna. Systemic, neurologic, and histopathologic findings of meningitis were observed in all rabbits, but an inoculum of 2 × 104 arthroconidia produced a chronic illness in which meningeal endarteritis obliterans was consistently observed. Serial sampling of cerebrospinal fluid demonstrated an inflammatory response. Growth of C. immitis was demonstrated by quantitative fungal culture from brains and proximal spinal cords.</description><subject>Animal models</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Central Nervous System - blood supply</subject><subject>Central Nervous System - microbiology</subject><subject>Central Nervous System - pathology</subject><subject>Cerebrospinal fluid</subject><subject>Coccidioides</subject><subject>Coccidioidomycosis - cerebrospinal fluid</subject><subject>Coccidioidomycosis - etiology</subject><subject>Coccidioidomycosis - pathology</subject><subject>Concise Comunications</subject><subject>Disease models</subject><subject>Disease Models, Animal</subject><subject>Endarteritis - etiology</subject><subject>Endarteritis - pathology</subject><subject>Experimental mycoses and models</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Inoculum</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Meningitis</subject><subject>Meningoencephalitis - etiology</subject><subject>Meningoencephalitis - pathology</subject><subject>Mycoses</subject><subject>Nervous system diseases</subject><subject>Rabbits</subject><subject>Spinal cord</subject><subject>Subarachnoid space</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkF1rFDEUhoModa36D4RBxLvRk2RyMrksi1qhH1B1kb0JmSRjs85OtskMtP_elF224NW5eB7ew_sS8pbCJwotfhZUYKuekQUVXNaIlD8nCwDGatoq9ZK8ynkDAA1HeUJOVAsIKBZkdVZdRueHKvbVMlobXIjBmaG69GMY_0Q_Wr-7NUOYQq7M6KqlT75LMe_CWKyVyXbewzBW062vbkzXhek1edGbIfs3h3tKfn398nN5Xl9cf_u-PLuobcOaqUbDrZJtz1BJ0ziOnAumWCNayxAYVyiQUlRcKugAnBLKgXG97JvHi_yUfNzn7lK8m32e9DZk64fBjD7OWcuyAKLgRXz_n7iJcyoVsmblD2US-VOaLQVz8r3epbA16UFT0I8r6_3KRXx3SJu7rXdH7TBr4R8OvOxjhj6Z0YZ81FgpLzl9itnkKaYj5kCpZNAWXu95yJO_P3KT_mqUXAp9_nut4UZd4frHSq_5P_NNmUo</recordid><startdate>19981001</startdate><enddate>19981001</enddate><creator>Williams, P. L.</creator><creator>Sobel, R. A.</creator><creator>Sorensen, K. N.</creator><creator>Clemons, K. V.</creator><creator>Shuer, L. M.</creator><creator>Royaltey, S. S.</creator><creator>Yao, Y.</creator><creator>Pappagianis, D.</creator><creator>Lutz, J. E.</creator><creator>Reed, C.</creator><creator>River, M. E.</creator><creator>Lee, B. C.</creator><creator>Bhatti, S. U.</creator><creator>Stevens, D. A.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>19981001</creationdate><title>A Model of Coccidioidal Meningoencephalitis and Cerebrospinal Vasculitis in the Rabbit</title><author>Williams, P. L. ; Sobel, R. A. ; Sorensen, K. N. ; Clemons, K. V. ; Shuer, L. M. ; Royaltey, S. S. ; Yao, Y. ; Pappagianis, D. ; Lutz, J. E. ; Reed, C. ; River, M. E. ; Lee, B. C. ; Bhatti, S. U. ; Stevens, D. 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A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Model of Coccidioidal Meningoencephalitis and Cerebrospinal Vasculitis in the Rabbit</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>The Journal of Infectious Diseases</addtitle><date>1998-10-01</date><risdate>1998</risdate><volume>178</volume><issue>4</issue><spage>1217</spage><epage>1221</epage><pages>1217-1221</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Coccidioidal meningitis is a devastating complication of disseminated coccidioidomycosis. An animal model of this infection could enhance understanding of the pathogenesis of the disease and lead to improvements in therapy. A rabbit model of central nervous system infection simulating human disease was established using a blind cisternal tap technique to inoculate 4 × 103−1 × 106 arthroconidia of Coccidioides immitis into the cisterna magna. Systemic, neurologic, and histopathologic findings of meningitis were observed in all rabbits, but an inoculum of 2 × 104 arthroconidia produced a chronic illness in which meningeal endarteritis obliterans was consistently observed. Serial sampling of cerebrospinal fluid demonstrated an inflammatory response. Growth of C. immitis was demonstrated by quantitative fungal culture from brains and proximal spinal cords.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>9806065</pmid><doi>10.1086/515689</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of infectious diseases, 1998-10, Vol.178 (4), p.1217-1221 |
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| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Animal models Animals Biological and medical sciences Central Nervous System - blood supply Central Nervous System - microbiology Central Nervous System - pathology Cerebrospinal fluid Coccidioides Coccidioidomycosis - cerebrospinal fluid Coccidioidomycosis - etiology Coccidioidomycosis - pathology Concise Comunications Disease models Disease Models, Animal Endarteritis - etiology Endarteritis - pathology Experimental mycoses and models Infections Infectious diseases Inoculum Male Medical sciences Meningitis Meningoencephalitis - etiology Meningoencephalitis - pathology Mycoses Nervous system diseases Rabbits Spinal cord Subarachnoid space |
| title | A Model of Coccidioidal Meningoencephalitis and Cerebrospinal Vasculitis in the Rabbit |
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