Organising activities of engrailed, hedgehog, wingless and decapentaplegic in the genital discs of Drosophila melanogaster
The genes engrailed (en), hedgehog (hh), wingless (wg) and decapentaplegic (dpp) have been shown to play vital organising roles in the development and differentiation of thoracic imaginal discs. We have analysed the roles of these genes in organising the development and differentiation of the genita...
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| Veröffentlicht in: | Development genes and evolution 1998-11, Vol.208 (9), p.504-516 |
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| creator | Emerald, B S Roy, J K |
| description | The genes engrailed (en), hedgehog (hh), wingless (wg) and decapentaplegic (dpp) have been shown to play vital organising roles in the development and differentiation of thoracic imaginal discs. We have analysed the roles of these genes in organising the development and differentiation of the genital discs, which are bilaterally symmetrical and possess different primordia, namely, the male and female genital primordia and an anal primordium. Our results suggest that the organising activity of en in genital discs programs the normal development and differentiation of the genital disc by regulating the expression of hh. Hh in turn induces wg and dpp, the genes whose products act as secondary signalling molecules. Moreover, the complementary patterns of wg and dpp expression are essential for the bilateral symmetry and are maintained by mutual repression. |
| doi_str_mv | 10.1007/s004270050209 |
| format | Article |
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Moreover, the complementary patterns of wg and dpp expression are essential for the bilateral symmetry and are maintained by mutual repression.</description><identifier>ISSN: 0949-944X</identifier><identifier>EISSN: 1432-041X</identifier><identifier>DOI: 10.1007/s004270050209</identifier><identifier>PMID: 9799432</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Animals ; Cell Differentiation ; Drosophila melanogaster ; Drosophila melanogaster - genetics ; Drosophila melanogaster - growth & development ; Drosophila Proteins ; Female ; Genitalia - cytology ; Genitalia - growth & development ; Hedgehog Proteins ; Homeodomain Proteins - genetics ; Insect Proteins - genetics ; Male ; Proto-Oncogene Proteins - genetics ; Transcription Factors - genetics ; Wnt1 Protein</subject><ispartof>Development genes and evolution, 1998-11, Vol.208 (9), p.504-516</ispartof><rights>Springer-Verlag Berlin Heidelberg 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c346t-3279b67a8d7c2f46a22cc828aad2bc013af20579004193158c27acab6a3c95193</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9799432$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Emerald, B S</creatorcontrib><creatorcontrib>Roy, J K</creatorcontrib><title>Organising activities of engrailed, hedgehog, wingless and decapentaplegic in the genital discs of Drosophila melanogaster</title><title>Development genes and evolution</title><addtitle>Dev Genes Evol</addtitle><description>The genes engrailed (en), hedgehog (hh), wingless (wg) and decapentaplegic (dpp) have been shown to play vital organising roles in the development and differentiation of thoracic imaginal discs. 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| ispartof | Development genes and evolution, 1998-11, Vol.208 (9), p.504-516 |
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| subjects | Animals Cell Differentiation Drosophila melanogaster Drosophila melanogaster - genetics Drosophila melanogaster - growth & development Drosophila Proteins Female Genitalia - cytology Genitalia - growth & development Hedgehog Proteins Homeodomain Proteins - genetics Insect Proteins - genetics Male Proto-Oncogene Proteins - genetics Transcription Factors - genetics Wnt1 Protein |
| title | Organising activities of engrailed, hedgehog, wingless and decapentaplegic in the genital discs of Drosophila melanogaster |
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