Fibrogenesis imperfecta ossium : imaging correlation in three new patients

Fibrogenesis imperfecta ossium is an extremely rare disorder that can easily be misdiagnosed. We retrospectively reviewed the clinical and imaging data of three confirmed cases of fibrogenesis imperfecta. The patients consisted of two men and one woman, ranging in age from 40 to 53 years. Radiograph...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Skeletal radiology 1999-07, Vol.28 (7), p.390-395
Hauptverfasser: WANG, C. S. F, STEINBACH, L. S, CAMPBELL, J. B, HAYASHI, G, YOON, S. T, JOHNSTON, J. O
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 395
container_issue 7
container_start_page 390
container_title Skeletal radiology
container_volume 28
creator WANG, C. S. F
STEINBACH, L. S
CAMPBELL, J. B
HAYASHI, G
YOON, S. T
JOHNSTON, J. O
description Fibrogenesis imperfecta ossium is an extremely rare disorder that can easily be misdiagnosed. We retrospectively reviewed the clinical and imaging data of three confirmed cases of fibrogenesis imperfecta. The patients consisted of two men and one woman, ranging in age from 40 to 53 years. Radiography was performed in all the patients. One patient had a 3-year follow-up of the thoracolumbar spine with conventional radiography and thoracolumbar magnetic resonance (MR) imaging. Open biopsy was performed in all cases, confirming the diagnosis of fibrogenesis imperfecta ossium. All our cases demonstrated "fishnet" trabecular pattern by conventional radiographs, and a pelvis radiograph of one patient showed an equivocal sclerosis pattern. Multiple fractures were noted in two patients. A pseudoexostosis was present in the ilium in one patient. Thoracolumbar MR imaging demonstrated diffuse low signal intensity within the medullary space on both T1-weighed and T2-weighted images, except for a region of increased signal intensity in the L1 and L2 vertebral bodies on T2-weighed images due to edema from acute collapse. Although uncommon, fibrogenesis imperfecta ossium should be considered in a previously healthy patient with a combination of progressive bone pain, unexplained fractures, a radiologic pattern of fishnet osteopenia and MR imaging of low signal intensity bone marrow on both T1-weighted and T2-weighted images.
doi_str_mv 10.1007/s002560050535
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70023980</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70023980</sourcerecordid><originalsourceid>FETCH-LOGICAL-c377t-624da4268816e29bef02b93f552c9a93c1c414ff3753499f0960c7e1d24bca723</originalsourceid><addsrcrecordid>eNqF0c9L5DAUB_AgKzo7evS6FFb2Vn350aTZmwy6KgNe9FzSzMsYadMxaRH_ezPMgOte9hR4fPg-8n2EnFG4oADqMgGwSgJUUPHqgMyo4KxkVNJvZAZcipJxUR-T7ym9AFClKnlEjikIVUsGM3J_49s4rDFg8qnw_QajQzuaYkjJT33xO8_M2od1YYcYsTOjH0LhQzE-R8Qi4FuxyTMMYzohh850CU_375w83Vw_Lm7L5cOfu8XVsrRcqbGUTKyMYLKuqUSmW3TAWs1dVTGrjeaWWkGFc1xVXGjtQEuwCumKidYaxfic_NrlbuLwOmEam94ni11nAg5TalRuhOsa_gupYnlH7m1Ofv4DX4YphvyJhgJjVIHWW1XulI25nIiu2cRcTnzPqNneovlyi-x_7FOntsfVX3pXfgbne2CSNZ2LJlifPp3extT8A0NFjp8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1022170995</pqid></control><display><type>article</type><title>Fibrogenesis imperfecta ossium : imaging correlation in three new patients</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>WANG, C. S. F ; STEINBACH, L. S ; CAMPBELL, J. B ; HAYASHI, G ; YOON, S. T ; JOHNSTON, J. O</creator><creatorcontrib>WANG, C. S. F ; STEINBACH, L. S ; CAMPBELL, J. B ; HAYASHI, G ; YOON, S. T ; JOHNSTON, J. O</creatorcontrib><description>Fibrogenesis imperfecta ossium is an extremely rare disorder that can easily be misdiagnosed. We retrospectively reviewed the clinical and imaging data of three confirmed cases of fibrogenesis imperfecta. The patients consisted of two men and one woman, ranging in age from 40 to 53 years. Radiography was performed in all the patients. One patient had a 3-year follow-up of the thoracolumbar spine with conventional radiography and thoracolumbar magnetic resonance (MR) imaging. Open biopsy was performed in all cases, confirming the diagnosis of fibrogenesis imperfecta ossium. All our cases demonstrated "fishnet" trabecular pattern by conventional radiographs, and a pelvis radiograph of one patient showed an equivocal sclerosis pattern. Multiple fractures were noted in two patients. A pseudoexostosis was present in the ilium in one patient. Thoracolumbar MR imaging demonstrated diffuse low signal intensity within the medullary space on both T1-weighed and T2-weighted images, except for a region of increased signal intensity in the L1 and L2 vertebral bodies on T2-weighed images due to edema from acute collapse. Although uncommon, fibrogenesis imperfecta ossium should be considered in a previously healthy patient with a combination of progressive bone pain, unexplained fractures, a radiologic pattern of fishnet osteopenia and MR imaging of low signal intensity bone marrow on both T1-weighted and T2-weighted images.</description><identifier>ISSN: 0364-2348</identifier><identifier>EISSN: 1432-2161</identifier><identifier>DOI: 10.1007/s002560050535</identifier><identifier>PMID: 10478620</identifier><identifier>CODEN: SKRADI</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adult ; Biological and medical sciences ; Bone and Bones - diagnostic imaging ; Bone and Bones - pathology ; Bone Diseases, Metabolic - diagnosis ; Bone Diseases, Metabolic - diagnostic imaging ; Collagen Diseases - diagnosis ; Collagen Diseases - diagnostic imaging ; Diseases of the osteoarticular system ; Female ; Fractures, Spontaneous - diagnosis ; Fractures, Spontaneous - diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Male ; Medical research ; Medical sciences ; Middle Aged ; Miscellaneous. Osteoarticular involvement in other diseases ; NMR ; Nuclear magnetic resonance ; Radiography ; Retrospective Studies ; Spine - diagnostic imaging</subject><ispartof>Skeletal radiology, 1999-07, Vol.28 (7), p.390-395</ispartof><rights>1999 INIST-CNRS</rights><rights>International Skeletal Society 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-624da4268816e29bef02b93f552c9a93c1c414ff3753499f0960c7e1d24bca723</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=1905358$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10478620$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WANG, C. S. F</creatorcontrib><creatorcontrib>STEINBACH, L. S</creatorcontrib><creatorcontrib>CAMPBELL, J. B</creatorcontrib><creatorcontrib>HAYASHI, G</creatorcontrib><creatorcontrib>YOON, S. T</creatorcontrib><creatorcontrib>JOHNSTON, J. O</creatorcontrib><title>Fibrogenesis imperfecta ossium : imaging correlation in three new patients</title><title>Skeletal radiology</title><addtitle>Skeletal Radiol</addtitle><description>Fibrogenesis imperfecta ossium is an extremely rare disorder that can easily be misdiagnosed. We retrospectively reviewed the clinical and imaging data of three confirmed cases of fibrogenesis imperfecta. The patients consisted of two men and one woman, ranging in age from 40 to 53 years. Radiography was performed in all the patients. One patient had a 3-year follow-up of the thoracolumbar spine with conventional radiography and thoracolumbar magnetic resonance (MR) imaging. Open biopsy was performed in all cases, confirming the diagnosis of fibrogenesis imperfecta ossium. All our cases demonstrated "fishnet" trabecular pattern by conventional radiographs, and a pelvis radiograph of one patient showed an equivocal sclerosis pattern. Multiple fractures were noted in two patients. A pseudoexostosis was present in the ilium in one patient. Thoracolumbar MR imaging demonstrated diffuse low signal intensity within the medullary space on both T1-weighed and T2-weighted images, except for a region of increased signal intensity in the L1 and L2 vertebral bodies on T2-weighed images due to edema from acute collapse. Although uncommon, fibrogenesis imperfecta ossium should be considered in a previously healthy patient with a combination of progressive bone pain, unexplained fractures, a radiologic pattern of fishnet osteopenia and MR imaging of low signal intensity bone marrow on both T1-weighted and T2-weighted images.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Bone and Bones - diagnostic imaging</subject><subject>Bone and Bones - pathology</subject><subject>Bone Diseases, Metabolic - diagnosis</subject><subject>Bone Diseases, Metabolic - diagnostic imaging</subject><subject>Collagen Diseases - diagnosis</subject><subject>Collagen Diseases - diagnostic imaging</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Fractures, Spontaneous - diagnosis</subject><subject>Fractures, Spontaneous - diagnostic imaging</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous. Osteoarticular involvement in other diseases</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Radiography</subject><subject>Retrospective Studies</subject><subject>Spine - diagnostic imaging</subject><issn>0364-2348</issn><issn>1432-2161</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0c9L5DAUB_AgKzo7evS6FFb2Vn350aTZmwy6KgNe9FzSzMsYadMxaRH_ezPMgOte9hR4fPg-8n2EnFG4oADqMgGwSgJUUPHqgMyo4KxkVNJvZAZcipJxUR-T7ym9AFClKnlEjikIVUsGM3J_49s4rDFg8qnw_QajQzuaYkjJT33xO8_M2od1YYcYsTOjH0LhQzE-R8Qi4FuxyTMMYzohh850CU_375w83Vw_Lm7L5cOfu8XVsrRcqbGUTKyMYLKuqUSmW3TAWs1dVTGrjeaWWkGFc1xVXGjtQEuwCumKidYaxfic_NrlbuLwOmEam94ni11nAg5TalRuhOsa_gupYnlH7m1Ofv4DX4YphvyJhgJjVIHWW1XulI25nIiu2cRcTnzPqNneovlyi-x_7FOntsfVX3pXfgbne2CSNZ2LJlifPp3extT8A0NFjp8</recordid><startdate>19990701</startdate><enddate>19990701</enddate><creator>WANG, C. S. F</creator><creator>STEINBACH, L. S</creator><creator>CAMPBELL, J. B</creator><creator>HAYASHI, G</creator><creator>YOON, S. T</creator><creator>JOHNSTON, J. O</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>19990701</creationdate><title>Fibrogenesis imperfecta ossium : imaging correlation in three new patients</title><author>WANG, C. S. F ; STEINBACH, L. S ; CAMPBELL, J. B ; HAYASHI, G ; YOON, S. T ; JOHNSTON, J. O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-624da4268816e29bef02b93f552c9a93c1c414ff3753499f0960c7e1d24bca723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Bone and Bones - diagnostic imaging</topic><topic>Bone and Bones - pathology</topic><topic>Bone Diseases, Metabolic - diagnosis</topic><topic>Bone Diseases, Metabolic - diagnostic imaging</topic><topic>Collagen Diseases - diagnosis</topic><topic>Collagen Diseases - diagnostic imaging</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Fractures, Spontaneous - diagnosis</topic><topic>Fractures, Spontaneous - diagnostic imaging</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous. Osteoarticular involvement in other diseases</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Radiography</topic><topic>Retrospective Studies</topic><topic>Spine - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WANG, C. S. F</creatorcontrib><creatorcontrib>STEINBACH, L. S</creatorcontrib><creatorcontrib>CAMPBELL, J. B</creatorcontrib><creatorcontrib>HAYASHI, G</creatorcontrib><creatorcontrib>YOON, S. T</creatorcontrib><creatorcontrib>JOHNSTON, J. O</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Skeletal radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WANG, C. S. F</au><au>STEINBACH, L. S</au><au>CAMPBELL, J. B</au><au>HAYASHI, G</au><au>YOON, S. T</au><au>JOHNSTON, J. O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fibrogenesis imperfecta ossium : imaging correlation in three new patients</atitle><jtitle>Skeletal radiology</jtitle><addtitle>Skeletal Radiol</addtitle><date>1999-07-01</date><risdate>1999</risdate><volume>28</volume><issue>7</issue><spage>390</spage><epage>395</epage><pages>390-395</pages><issn>0364-2348</issn><eissn>1432-2161</eissn><coden>SKRADI</coden><abstract>Fibrogenesis imperfecta ossium is an extremely rare disorder that can easily be misdiagnosed. We retrospectively reviewed the clinical and imaging data of three confirmed cases of fibrogenesis imperfecta. The patients consisted of two men and one woman, ranging in age from 40 to 53 years. Radiography was performed in all the patients. One patient had a 3-year follow-up of the thoracolumbar spine with conventional radiography and thoracolumbar magnetic resonance (MR) imaging. Open biopsy was performed in all cases, confirming the diagnosis of fibrogenesis imperfecta ossium. All our cases demonstrated "fishnet" trabecular pattern by conventional radiographs, and a pelvis radiograph of one patient showed an equivocal sclerosis pattern. Multiple fractures were noted in two patients. A pseudoexostosis was present in the ilium in one patient. Thoracolumbar MR imaging demonstrated diffuse low signal intensity within the medullary space on both T1-weighed and T2-weighted images, except for a region of increased signal intensity in the L1 and L2 vertebral bodies on T2-weighed images due to edema from acute collapse. Although uncommon, fibrogenesis imperfecta ossium should be considered in a previously healthy patient with a combination of progressive bone pain, unexplained fractures, a radiologic pattern of fishnet osteopenia and MR imaging of low signal intensity bone marrow on both T1-weighted and T2-weighted images.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>10478620</pmid><doi>10.1007/s002560050535</doi><tpages>6</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0364-2348
ispartof Skeletal radiology, 1999-07, Vol.28 (7), p.390-395
issn 0364-2348
1432-2161
language eng
recordid cdi_proquest_miscellaneous_70023980
source MEDLINE; SpringerLink Journals - AutoHoldings
subjects Adult
Biological and medical sciences
Bone and Bones - diagnostic imaging
Bone and Bones - pathology
Bone Diseases, Metabolic - diagnosis
Bone Diseases, Metabolic - diagnostic imaging
Collagen Diseases - diagnosis
Collagen Diseases - diagnostic imaging
Diseases of the osteoarticular system
Female
Fractures, Spontaneous - diagnosis
Fractures, Spontaneous - diagnostic imaging
Humans
Magnetic Resonance Imaging
Male
Medical research
Medical sciences
Middle Aged
Miscellaneous. Osteoarticular involvement in other diseases
NMR
Nuclear magnetic resonance
Radiography
Retrospective Studies
Spine - diagnostic imaging
title Fibrogenesis imperfecta ossium : imaging correlation in three new patients
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T22%3A45%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Fibrogenesis%20imperfecta%20ossium%20:%20imaging%20correlation%20in%20three%20new%20patients&rft.jtitle=Skeletal%20radiology&rft.au=WANG,%20C.%20S.%20F&rft.date=1999-07-01&rft.volume=28&rft.issue=7&rft.spage=390&rft.epage=395&rft.pages=390-395&rft.issn=0364-2348&rft.eissn=1432-2161&rft.coden=SKRADI&rft_id=info:doi/10.1007/s002560050535&rft_dat=%3Cproquest_cross%3E70023980%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1022170995&rft_id=info:pmid/10478620&rfr_iscdi=true