Pharmacological basis for the use of the antivenene water soluble extract of Diodia scandens as a laxative, oxytocic agent and a possible aphrodisiac in traditional medicine practice in Eastern Nigeria
The effects of the antivenene fraction of an ethanol extract of Diodia scandens on some mammalian smooth muscles were investigated. On the guinea‐pig ileum, the extract was shown to be a partial agonist acting via muscarinic receptors. Acetylcholine (ACh) was 2.5 × 105 times more potent. On the preg...
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| Veröffentlicht in: | Phytotherapy research 1999-09, Vol.13 (6), p.459-463 |
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| description | The effects of the antivenene fraction of an ethanol extract of Diodia scandens on some mammalian smooth muscles were investigated. On the guinea‐pig ileum, the extract was shown to be a partial agonist acting via muscarinic receptors. Acetylcholine (ACh) was 2.5 × 105 times more potent. On the pregnant guinea‐pig uterus, the extract induced concentration‐dependent increases in the force of contraction and tonus. Oxytocin and ergometrine were respectively 106 and 103 times more potent.
The extract, at subliminal concentrations, potentiated ACh and adrenaline‐induced contractions in the guinea‐pig was deferens. It also induced dose‐related vasodilatation in the rat hindquarters and depressed the blood pressure in the anaesthetized cat. It was concluded that these pharmacological actions offer some scientific explanation for the use of Diodia scandens in traditional medicine as a laxative and as an oxytocic agent. It is suggested that the extract could enhance erection and ejaculatory processes in the male, thus accounting for its regular use by some elderly males. Copyright © 1999 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/(SICI)1099-1573(199909)13:6<459::AID-PTR468>3.0.CO;2-E |
| format | Article |
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The extract, at subliminal concentrations, potentiated ACh and adrenaline‐induced contractions in the guinea‐pig was deferens. It also induced dose‐related vasodilatation in the rat hindquarters and depressed the blood pressure in the anaesthetized cat. It was concluded that these pharmacological actions offer some scientific explanation for the use of Diodia scandens in traditional medicine as a laxative and as an oxytocic agent. It is suggested that the extract could enhance erection and ejaculatory processes in the male, thus accounting for its regular use by some elderly males. Copyright © 1999 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/(SICI)1099-1573(199909)13:6<459::AID-PTR468>3.0.CO;2-E</identifier><identifier>PMID: 10479753</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Acetylcholine - pharmacology ; Animals ; antivenene ethanol extract ; Aphrodisiacs - pharmacology ; Biological and medical sciences ; Blood Pressure - drug effects ; Cathartics - pharmacology ; Cats ; Diodia scandens ; Epinephrine - pharmacology ; Ergonovine - pharmacology ; Female ; General pharmacology ; Guinea Pigs ; Ileum - drug effects ; In Vitro Techniques ; laxative ; Male ; Medical sciences ; Medicine, African Traditional ; Muscarinic Agonists - pharmacology ; Muscle Contraction - drug effects ; Muscle, Smooth - drug effects ; Nigeria ; oxytocic activity ; Oxytocics - pharmacology ; Oxytocin - pharmacology ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Extracts - pharmacology ; Pregnancy ; Rats ; Respiration - drug effects ; traditional medicine ; Uterine Contraction - drug effects ; Vas Deferens - drug effects ; Vasodilation - drug effects ; Water</subject><ispartof>Phytotherapy research, 1999-09, Vol.13 (6), p.459-463</ispartof><rights>Copyright © 1999 John Wiley & Sons, Ltd.</rights><rights>1999 INIST-CNRS</rights><rights>Copyright 1999 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4588-47e3138deaf8af1b4b33fcb73b9300e3cc5605ea5ec62faa33228f54b52a34273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291099-1573%28199909%2913%3A6%3C459%3A%3AAID-PTR468%3E3.0.CO%3B2-E$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291099-1573%28199909%2913%3A6%3C459%3A%3AAID-PTR468%3E3.0.CO%3B2-E$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1971493$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10479753$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Onuaguluchi, G</creatorcontrib><creatorcontrib>Nwafor, P</creatorcontrib><title>Pharmacological basis for the use of the antivenene water soluble extract of Diodia scandens as a laxative, oxytocic agent and a possible aphrodisiac in traditional medicine practice in Eastern Nigeria</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>The effects of the antivenene fraction of an ethanol extract of Diodia scandens on some mammalian smooth muscles were investigated. On the guinea‐pig ileum, the extract was shown to be a partial agonist acting via muscarinic receptors. Acetylcholine (ACh) was 2.5 × 105 times more potent. On the pregnant guinea‐pig uterus, the extract induced concentration‐dependent increases in the force of contraction and tonus. Oxytocin and ergometrine were respectively 106 and 103 times more potent.
The extract, at subliminal concentrations, potentiated ACh and adrenaline‐induced contractions in the guinea‐pig was deferens. It also induced dose‐related vasodilatation in the rat hindquarters and depressed the blood pressure in the anaesthetized cat. It was concluded that these pharmacological actions offer some scientific explanation for the use of Diodia scandens in traditional medicine as a laxative and as an oxytocic agent. It is suggested that the extract could enhance erection and ejaculatory processes in the male, thus accounting for its regular use by some elderly males. Copyright © 1999 John Wiley & Sons, Ltd.</description><subject>Acetylcholine - pharmacology</subject><subject>Animals</subject><subject>antivenene ethanol extract</subject><subject>Aphrodisiacs - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Cathartics - pharmacology</subject><subject>Cats</subject><subject>Diodia scandens</subject><subject>Epinephrine - pharmacology</subject><subject>Ergonovine - pharmacology</subject><subject>Female</subject><subject>General pharmacology</subject><subject>Guinea Pigs</subject><subject>Ileum - drug effects</subject><subject>In Vitro Techniques</subject><subject>laxative</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine, African Traditional</subject><subject>Muscarinic Agonists - pharmacology</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle, Smooth - drug effects</subject><subject>Nigeria</subject><subject>oxytocic activity</subject><subject>Oxytocics - pharmacology</subject><subject>Oxytocin - pharmacology</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - pharmacology</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Respiration - drug effects</subject><subject>traditional medicine</subject><subject>Uterine Contraction - drug effects</subject><subject>Vas Deferens - drug effects</subject><subject>Vasodilation - drug effects</subject><subject>Water</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkdFu0zAUhiMEYmPwCuALhDaJFDuOk7igSVPXjcK0TWxjuzs6cZ3OkMbFTln7iLwVDqkGEkgolhIl3_n9O18U7TM6YJQmb3YvJqPJHqNSxkzkfJdJKancY3yYvUuFHA4PJofx-eWnNCv2-YAORmdvk3j8INq-H3kYbVMpWJyy4mYreuL9F0qpTGj6ONpiNM1lLvh29OP8Ft0cla3tzCisSYneeFJZR9pbTZZeE1v9esSmNd91Ey5yh612xNt6Wdaa6FXrULUdd2js1CDxCpupbjzBsEiNK-xGXxO7WrdWGUVwpps2JE7D54X13nQ5uLh1YdwbVMQ0JIROTWtsE0rN9dQoE3ZedDsZpTtgjD7UaMipmWln8Gn0qMLa62eb-050dTS-HL2PT86OJ6ODk1iloijiNNec8WKqsSqwYmVacl6pMuel5JRqrpTIqNAotMqSCpHzJCkqkZYiQZ4mOd-JXvW5C2e_LbVvYW680nWNjbZLD3nQxzORBfBzDyoXjuh0BQtn5ujWwCh0kgE6ydAZg84Y9JKBccggSAYIkqGXDBwojM4ggXEIfr5psCzDn_kjtrcagJcbAIOKunLYKON_czJnqeywmx67M7Ve_9XuP-X-2W3zJkTHfbQJjlb30ei-QpbzXMD16TGMimN68fHDEVwH_kXPV2gBZy60vbpIKOM0kYJSXvCfWBbsqQ</recordid><startdate>199909</startdate><enddate>199909</enddate><creator>Onuaguluchi, G</creator><creator>Nwafor, P</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199909</creationdate><title>Pharmacological basis for the use of the antivenene water soluble extract of Diodia scandens as a laxative, oxytocic agent and a possible aphrodisiac in traditional medicine practice in Eastern Nigeria</title><author>Onuaguluchi, G ; Nwafor, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4588-47e3138deaf8af1b4b33fcb73b9300e3cc5605ea5ec62faa33228f54b52a34273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Acetylcholine - pharmacology</topic><topic>Animals</topic><topic>antivenene ethanol extract</topic><topic>Aphrodisiacs - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Cathartics - pharmacology</topic><topic>Cats</topic><topic>Diodia scandens</topic><topic>Epinephrine - pharmacology</topic><topic>Ergonovine - pharmacology</topic><topic>Female</topic><topic>General pharmacology</topic><topic>Guinea Pigs</topic><topic>Ileum - drug effects</topic><topic>In Vitro Techniques</topic><topic>laxative</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine, African Traditional</topic><topic>Muscarinic Agonists - pharmacology</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle, Smooth - drug effects</topic><topic>Nigeria</topic><topic>oxytocic activity</topic><topic>Oxytocics - pharmacology</topic><topic>Oxytocin - pharmacology</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - pharmacology</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Respiration - drug effects</topic><topic>traditional medicine</topic><topic>Uterine Contraction - drug effects</topic><topic>Vas Deferens - drug effects</topic><topic>Vasodilation - drug effects</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Onuaguluchi, G</creatorcontrib><creatorcontrib>Nwafor, P</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Onuaguluchi, G</au><au>Nwafor, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacological basis for the use of the antivenene water soluble extract of Diodia scandens as a laxative, oxytocic agent and a possible aphrodisiac in traditional medicine practice in Eastern Nigeria</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>1999-09</date><risdate>1999</risdate><volume>13</volume><issue>6</issue><spage>459</spage><epage>463</epage><pages>459-463</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>The effects of the antivenene fraction of an ethanol extract of Diodia scandens on some mammalian smooth muscles were investigated. On the guinea‐pig ileum, the extract was shown to be a partial agonist acting via muscarinic receptors. Acetylcholine (ACh) was 2.5 × 105 times more potent. On the pregnant guinea‐pig uterus, the extract induced concentration‐dependent increases in the force of contraction and tonus. Oxytocin and ergometrine were respectively 106 and 103 times more potent.
The extract, at subliminal concentrations, potentiated ACh and adrenaline‐induced contractions in the guinea‐pig was deferens. It also induced dose‐related vasodilatation in the rat hindquarters and depressed the blood pressure in the anaesthetized cat. It was concluded that these pharmacological actions offer some scientific explanation for the use of Diodia scandens in traditional medicine as a laxative and as an oxytocic agent. It is suggested that the extract could enhance erection and ejaculatory processes in the male, thus accounting for its regular use by some elderly males. Copyright © 1999 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>10479753</pmid><doi>10.1002/(SICI)1099-1573(199909)13:6<459::AID-PTR468>3.0.CO;2-E</doi><tpages>5</tpages></addata></record> |
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| subjects | Acetylcholine - pharmacology Animals antivenene ethanol extract Aphrodisiacs - pharmacology Biological and medical sciences Blood Pressure - drug effects Cathartics - pharmacology Cats Diodia scandens Epinephrine - pharmacology Ergonovine - pharmacology Female General pharmacology Guinea Pigs Ileum - drug effects In Vitro Techniques laxative Male Medical sciences Medicine, African Traditional Muscarinic Agonists - pharmacology Muscle Contraction - drug effects Muscle, Smooth - drug effects Nigeria oxytocic activity Oxytocics - pharmacology Oxytocin - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - pharmacology Pregnancy Rats Respiration - drug effects traditional medicine Uterine Contraction - drug effects Vas Deferens - drug effects Vasodilation - drug effects Water |
| title | Pharmacological basis for the use of the antivenene water soluble extract of Diodia scandens as a laxative, oxytocic agent and a possible aphrodisiac in traditional medicine practice in Eastern Nigeria |
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