Effects of the calcium channel antagonist mibefradil on haemodynamic and morphological parameters in myocardial infarction-induced cardiac failure in rats

Calcium channel antagonists (CCA) have been proposed for the prevention of cardiac events after myocardial infarction (MI). Mibefradil is a CCA featuring a selective blockade of T-type Ca2(+)-channels. The aim of the study was to characterize the effects of mibefradil on haemodynamic and morphologic...

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Veröffentlicht in:	Cardiovascular research 1998-08, Vol.39 (2), p.339-350
Hauptverfasser:	SANDMANN, S, SPITZNAGEL, H, CHUNG, O, XIA, Q.-G, ILLNER, S, JÄNICHEN, G, ROSSIUS, B, DAEMEN, M. J. A. P, UNGER, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Benzimidazoles - administration & dosage Benzimidazoles - therapeutic use Biological and medical sciences Calcium Channel Blockers - administration & dosage Calcium Channel Blockers - therapeutic use Cardiovascular system Drug Administration Schedule Heart Failure - drug therapy Heart Failure - etiology Heart Failure - mortality Heart Failure - pathology Hemodynamics - drug effects Male Medical sciences Methoxamine - pharmacology Mibefradil Miscellaneous Myocardial Contraction - drug effects Myocardial Infarction - complications Myocardial Infarction - mortality Myocardial Infarction - pathology Myocardium - pathology Organ Size - drug effects Pharmacology. Drug treatments Rats Rats, Wistar Tetrahydronaphthalenes - administration & dosage Tetrahydronaphthalenes - therapeutic use Time Factors Vasoconstrictor Agents - pharmacology Vasodilator Agents - administration & dosage Vasodilator Agents - therapeutic use
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