Role of Respiratory Motor Output in Within-Breath Modulation of Muscle Sympathetic Nerve Activity in Humans

We measured muscle sympathetic nerve activity (MSNA, peroneal microneurography) in 5 healthy humans under conditions of matched tidal volume, breathing frequency, and end-tidal CO2, but varying respiratory motor output as follows(1) passive positive pressure mechanical ventilation, (2) voluntary hyp...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Circulation research 1999-09, Vol.85 (5), p.457-469
Hauptverfasser: St. Croix, Claudette M, Satoh, Makoto, Morgan, Barbara J, Skatrud, James B, Dempsey, Jerome A
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 469
container_issue 5
container_start_page 457
container_title Circulation research
container_volume 85
creator St. Croix, Claudette M
Satoh, Makoto
Morgan, Barbara J
Skatrud, James B
Dempsey, Jerome A
description We measured muscle sympathetic nerve activity (MSNA, peroneal microneurography) in 5 healthy humans under conditions of matched tidal volume, breathing frequency, and end-tidal CO2, but varying respiratory motor output as follows(1) passive positive pressure mechanical ventilation, (2) voluntary hyperventilation, (3) assisted mechanical ventilation that required the subject to generate −2.5 cm H2O to trigger each positive pressure breath, and (4) added inspiratory resistance. Spectral analyses showed marked respiratory periodicities in MSNA; however, the amplitude of the peak power was not changed with changing inspiratory effort. Time domain analyses showed that maximum MSNA always occurred at end expiration (25% to 30% of total activity) and minimum activity at end inspiration (2% to 3% of total activity), and the amplitude of the variation was not different among conditions despite marked changes in respiratory motor output. Furthermore, qualitative changes in intrathoracic pressure were without influence on the respiratory modulation of MSNA. In all conditions, within-breath changes in MSNA were inversely related to small changes in diastolic pressure (1 to 3 mm Hg), suggesting that respiratory rhythmicity in MSNA was secondary to loading/unloading of carotid sinus baroreceptors. Furthermore, at any given diastolic pressure, within-breath MSNA varied inversely with lung volume, demonstrating an additional influence of lung inflation feedback on sympathetic discharge. Our data provide evidence against a significant effect of respiratory motor output on the within-breath modulation of MSNA and suggest that feedback from baroreceptors and pulmonary stretch receptors are the dominant determinants of the respiratory modulation of MSNA in the intact human.
doi_str_mv 10.1161/01.res.85.5.457
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70022607</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70022607</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5838-99ff68e04eb8ac6c20d613cef3aa34482287a93a6965cec4525eacdd2961f2563</originalsourceid><addsrcrecordid>eNpdkU1rFEEQhgdRzCZ69iaDiLeZ9Pd0H2OIRkgMbBSPTaenhu1kZnrTHwn779PDLiieqqh66qXqrar6gFGLscCnCLcBYit5y1vGu1fVCnPCmpLi19UKIaSajlJ0VB3HeI8QZpSot9URRqyjouOr6mHtR6j9UK8hbl0wyYddfe1LqG9y2uZUu7n-49LGzc3XACZtSrfPo0nOz8vcdY62KNzupm1pQnK2_gnhCeozm9yTS7tF4DJPZo7vqjeDGSO8P8ST6ve3i1_nl83Vzfcf52dXjeWSykapYRASEIM7aaywBPUCUwsDNYYyJgmRnVHUCCW4Bcs44WBs3xMl8EC4oCfVl73uNvjHDDHpyUUL42hm8DnqDiFCBOoK-Ok_8N7nMJfdNMGEFSslLtDpHrLBxxhg0NvgJhN2GiO9PEEjrNcXt1pyzXVxvkx8PMjmuwn6f_i96wX4fABMtGYcgpmti385JajsljvYHnv2Y4IQH8b8DEFvwIxpo8tzEUWYNFgphVTJm6Uk6QtAVZ8E</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>212415281</pqid></control><display><type>article</type><title>Role of Respiratory Motor Output in Within-Breath Modulation of Muscle Sympathetic Nerve Activity in Humans</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>Journals@Ovid Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>St. Croix, Claudette M ; Satoh, Makoto ; Morgan, Barbara J ; Skatrud, James B ; Dempsey, Jerome A</creator><creatorcontrib>St. Croix, Claudette M ; Satoh, Makoto ; Morgan, Barbara J ; Skatrud, James B ; Dempsey, Jerome A</creatorcontrib><description>We measured muscle sympathetic nerve activity (MSNA, peroneal microneurography) in 5 healthy humans under conditions of matched tidal volume, breathing frequency, and end-tidal CO2, but varying respiratory motor output as follows(1) passive positive pressure mechanical ventilation, (2) voluntary hyperventilation, (3) assisted mechanical ventilation that required the subject to generate −2.5 cm H2O to trigger each positive pressure breath, and (4) added inspiratory resistance. Spectral analyses showed marked respiratory periodicities in MSNA; however, the amplitude of the peak power was not changed with changing inspiratory effort. Time domain analyses showed that maximum MSNA always occurred at end expiration (25% to 30% of total activity) and minimum activity at end inspiration (2% to 3% of total activity), and the amplitude of the variation was not different among conditions despite marked changes in respiratory motor output. Furthermore, qualitative changes in intrathoracic pressure were without influence on the respiratory modulation of MSNA. In all conditions, within-breath changes in MSNA were inversely related to small changes in diastolic pressure (1 to 3 mm Hg), suggesting that respiratory rhythmicity in MSNA was secondary to loading/unloading of carotid sinus baroreceptors. Furthermore, at any given diastolic pressure, within-breath MSNA varied inversely with lung volume, demonstrating an additional influence of lung inflation feedback on sympathetic discharge. Our data provide evidence against a significant effect of respiratory motor output on the within-breath modulation of MSNA and suggest that feedback from baroreceptors and pulmonary stretch receptors are the dominant determinants of the respiratory modulation of MSNA in the intact human.</description><identifier>ISSN: 0009-7330</identifier><identifier>EISSN: 1524-4571</identifier><identifier>DOI: 10.1161/01.res.85.5.457</identifier><identifier>PMID: 10473675</identifier><identifier>CODEN: CIRUAL</identifier><language>eng</language><publisher>Hagerstown, MD: American Heart Association, Inc</publisher><subject>Action Potentials ; Adult ; Biological and medical sciences ; Brain Stem - physiology ; Cardiorespiratory control. Arterial mecano- and chemoreceptor ; Carotid Sinus - physiology ; Diastole ; Feedback ; Fundamental and applied biological sciences. Psychology ; Humans ; Hyperventilation - physiopathology ; Inhalation - physiology ; Lung - physiology ; Lung Volume Measurements ; Male ; Middle Aged ; Muscle, Skeletal - innervation ; Periodicity ; Peroneal Nerve - physiology ; Phrenic Nerve - physiology ; Positive-Pressure Respiration ; Pressoreceptors - physiology ; Pressure ; Respiration, Artificial ; Respiratory Muscles - physiology ; Space life sciences ; Sympathetic Nervous System - physiology ; Vertebrates: respiratory system</subject><ispartof>Circulation research, 1999-09, Vol.85 (5), p.457-469</ispartof><rights>1999 American Heart Association, Inc.</rights><rights>1999 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Sep 3, 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5838-99ff68e04eb8ac6c20d613cef3aa34482287a93a6965cec4525eacdd2961f2563</citedby><cites>FETCH-LOGICAL-c5838-99ff68e04eb8ac6c20d613cef3aa34482287a93a6965cec4525eacdd2961f2563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,3688,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=1963876$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10473675$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>St. Croix, Claudette M</creatorcontrib><creatorcontrib>Satoh, Makoto</creatorcontrib><creatorcontrib>Morgan, Barbara J</creatorcontrib><creatorcontrib>Skatrud, James B</creatorcontrib><creatorcontrib>Dempsey, Jerome A</creatorcontrib><title>Role of Respiratory Motor Output in Within-Breath Modulation of Muscle Sympathetic Nerve Activity in Humans</title><title>Circulation research</title><addtitle>Circ Res</addtitle><description>We measured muscle sympathetic nerve activity (MSNA, peroneal microneurography) in 5 healthy humans under conditions of matched tidal volume, breathing frequency, and end-tidal CO2, but varying respiratory motor output as follows(1) passive positive pressure mechanical ventilation, (2) voluntary hyperventilation, (3) assisted mechanical ventilation that required the subject to generate −2.5 cm H2O to trigger each positive pressure breath, and (4) added inspiratory resistance. Spectral analyses showed marked respiratory periodicities in MSNA; however, the amplitude of the peak power was not changed with changing inspiratory effort. Time domain analyses showed that maximum MSNA always occurred at end expiration (25% to 30% of total activity) and minimum activity at end inspiration (2% to 3% of total activity), and the amplitude of the variation was not different among conditions despite marked changes in respiratory motor output. Furthermore, qualitative changes in intrathoracic pressure were without influence on the respiratory modulation of MSNA. In all conditions, within-breath changes in MSNA were inversely related to small changes in diastolic pressure (1 to 3 mm Hg), suggesting that respiratory rhythmicity in MSNA was secondary to loading/unloading of carotid sinus baroreceptors. Furthermore, at any given diastolic pressure, within-breath MSNA varied inversely with lung volume, demonstrating an additional influence of lung inflation feedback on sympathetic discharge. Our data provide evidence against a significant effect of respiratory motor output on the within-breath modulation of MSNA and suggest that feedback from baroreceptors and pulmonary stretch receptors are the dominant determinants of the respiratory modulation of MSNA in the intact human.</description><subject>Action Potentials</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Brain Stem - physiology</subject><subject>Cardiorespiratory control. Arterial mecano- and chemoreceptor</subject><subject>Carotid Sinus - physiology</subject><subject>Diastole</subject><subject>Feedback</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Hyperventilation - physiopathology</subject><subject>Inhalation - physiology</subject><subject>Lung - physiology</subject><subject>Lung Volume Measurements</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle, Skeletal - innervation</subject><subject>Periodicity</subject><subject>Peroneal Nerve - physiology</subject><subject>Phrenic Nerve - physiology</subject><subject>Positive-Pressure Respiration</subject><subject>Pressoreceptors - physiology</subject><subject>Pressure</subject><subject>Respiration, Artificial</subject><subject>Respiratory Muscles - physiology</subject><subject>Space life sciences</subject><subject>Sympathetic Nervous System - physiology</subject><subject>Vertebrates: respiratory system</subject><issn>0009-7330</issn><issn>1524-4571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1rFEEQhgdRzCZ69iaDiLeZ9Pd0H2OIRkgMbBSPTaenhu1kZnrTHwn779PDLiieqqh66qXqrar6gFGLscCnCLcBYit5y1vGu1fVCnPCmpLi19UKIaSajlJ0VB3HeI8QZpSot9URRqyjouOr6mHtR6j9UK8hbl0wyYddfe1LqG9y2uZUu7n-49LGzc3XACZtSrfPo0nOz8vcdY62KNzupm1pQnK2_gnhCeozm9yTS7tF4DJPZo7vqjeDGSO8P8ST6ve3i1_nl83Vzfcf52dXjeWSykapYRASEIM7aaywBPUCUwsDNYYyJgmRnVHUCCW4Bcs44WBs3xMl8EC4oCfVl73uNvjHDDHpyUUL42hm8DnqDiFCBOoK-Ok_8N7nMJfdNMGEFSslLtDpHrLBxxhg0NvgJhN2GiO9PEEjrNcXt1pyzXVxvkx8PMjmuwn6f_i96wX4fABMtGYcgpmti385JajsljvYHnv2Y4IQH8b8DEFvwIxpo8tzEUWYNFgphVTJm6Uk6QtAVZ8E</recordid><startdate>19990903</startdate><enddate>19990903</enddate><creator>St. Croix, Claudette M</creator><creator>Satoh, Makoto</creator><creator>Morgan, Barbara J</creator><creator>Skatrud, James B</creator><creator>Dempsey, Jerome A</creator><general>American Heart Association, Inc</general><general>Lippincott</general><general>Lippincott Williams &amp; Wilkins Ovid Technologies</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>19990903</creationdate><title>Role of Respiratory Motor Output in Within-Breath Modulation of Muscle Sympathetic Nerve Activity in Humans</title><author>St. Croix, Claudette M ; Satoh, Makoto ; Morgan, Barbara J ; Skatrud, James B ; Dempsey, Jerome A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5838-99ff68e04eb8ac6c20d613cef3aa34482287a93a6965cec4525eacdd2961f2563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Action Potentials</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Brain Stem - physiology</topic><topic>Cardiorespiratory control. Arterial mecano- and chemoreceptor</topic><topic>Carotid Sinus - physiology</topic><topic>Diastole</topic><topic>Feedback</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Hyperventilation - physiopathology</topic><topic>Inhalation - physiology</topic><topic>Lung - physiology</topic><topic>Lung Volume Measurements</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle, Skeletal - innervation</topic><topic>Periodicity</topic><topic>Peroneal Nerve - physiology</topic><topic>Phrenic Nerve - physiology</topic><topic>Positive-Pressure Respiration</topic><topic>Pressoreceptors - physiology</topic><topic>Pressure</topic><topic>Respiration, Artificial</topic><topic>Respiratory Muscles - physiology</topic><topic>Space life sciences</topic><topic>Sympathetic Nervous System - physiology</topic><topic>Vertebrates: respiratory system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>St. Croix, Claudette M</creatorcontrib><creatorcontrib>Satoh, Makoto</creatorcontrib><creatorcontrib>Morgan, Barbara J</creatorcontrib><creatorcontrib>Skatrud, James B</creatorcontrib><creatorcontrib>Dempsey, Jerome A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>St. Croix, Claudette M</au><au>Satoh, Makoto</au><au>Morgan, Barbara J</au><au>Skatrud, James B</au><au>Dempsey, Jerome A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Respiratory Motor Output in Within-Breath Modulation of Muscle Sympathetic Nerve Activity in Humans</atitle><jtitle>Circulation research</jtitle><addtitle>Circ Res</addtitle><date>1999-09-03</date><risdate>1999</risdate><volume>85</volume><issue>5</issue><spage>457</spage><epage>469</epage><pages>457-469</pages><issn>0009-7330</issn><eissn>1524-4571</eissn><coden>CIRUAL</coden><abstract>We measured muscle sympathetic nerve activity (MSNA, peroneal microneurography) in 5 healthy humans under conditions of matched tidal volume, breathing frequency, and end-tidal CO2, but varying respiratory motor output as follows(1) passive positive pressure mechanical ventilation, (2) voluntary hyperventilation, (3) assisted mechanical ventilation that required the subject to generate −2.5 cm H2O to trigger each positive pressure breath, and (4) added inspiratory resistance. Spectral analyses showed marked respiratory periodicities in MSNA; however, the amplitude of the peak power was not changed with changing inspiratory effort. Time domain analyses showed that maximum MSNA always occurred at end expiration (25% to 30% of total activity) and minimum activity at end inspiration (2% to 3% of total activity), and the amplitude of the variation was not different among conditions despite marked changes in respiratory motor output. Furthermore, qualitative changes in intrathoracic pressure were without influence on the respiratory modulation of MSNA. In all conditions, within-breath changes in MSNA were inversely related to small changes in diastolic pressure (1 to 3 mm Hg), suggesting that respiratory rhythmicity in MSNA was secondary to loading/unloading of carotid sinus baroreceptors. Furthermore, at any given diastolic pressure, within-breath MSNA varied inversely with lung volume, demonstrating an additional influence of lung inflation feedback on sympathetic discharge. Our data provide evidence against a significant effect of respiratory motor output on the within-breath modulation of MSNA and suggest that feedback from baroreceptors and pulmonary stretch receptors are the dominant determinants of the respiratory modulation of MSNA in the intact human.</abstract><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>10473675</pmid><doi>10.1161/01.res.85.5.457</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0009-7330
ispartof Circulation research, 1999-09, Vol.85 (5), p.457-469
issn 0009-7330
1524-4571
language eng
recordid cdi_proquest_miscellaneous_70022607
source MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals
subjects Action Potentials
Adult
Biological and medical sciences
Brain Stem - physiology
Cardiorespiratory control. Arterial mecano- and chemoreceptor
Carotid Sinus - physiology
Diastole
Feedback
Fundamental and applied biological sciences. Psychology
Humans
Hyperventilation - physiopathology
Inhalation - physiology
Lung - physiology
Lung Volume Measurements
Male
Middle Aged
Muscle, Skeletal - innervation
Periodicity
Peroneal Nerve - physiology
Phrenic Nerve - physiology
Positive-Pressure Respiration
Pressoreceptors - physiology
Pressure
Respiration, Artificial
Respiratory Muscles - physiology
Space life sciences
Sympathetic Nervous System - physiology
Vertebrates: respiratory system
title Role of Respiratory Motor Output in Within-Breath Modulation of Muscle Sympathetic Nerve Activity in Humans
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-12T01%3A28%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Role%20of%20Respiratory%20Motor%20Output%20in%20Within-Breath%20Modulation%20of%20Muscle%20Sympathetic%20Nerve%20Activity%20in%20Humans&rft.jtitle=Circulation%20research&rft.au=St.%20Croix,%20Claudette%20M&rft.date=1999-09-03&rft.volume=85&rft.issue=5&rft.spage=457&rft.epage=469&rft.pages=457-469&rft.issn=0009-7330&rft.eissn=1524-4571&rft.coden=CIRUAL&rft_id=info:doi/10.1161/01.res.85.5.457&rft_dat=%3Cproquest_cross%3E70022607%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=212415281&rft_id=info:pmid/10473675&rfr_iscdi=true