Role of Respiratory Motor Output in Within-Breath Modulation of Muscle Sympathetic Nerve Activity in Humans
We measured muscle sympathetic nerve activity (MSNA, peroneal microneurography) in 5 healthy humans under conditions of matched tidal volume, breathing frequency, and end-tidal CO2, but varying respiratory motor output as follows(1) passive positive pressure mechanical ventilation, (2) voluntary hyp...
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Veröffentlicht in: | Circulation research 1999-09, Vol.85 (5), p.457-469 |
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description | We measured muscle sympathetic nerve activity (MSNA, peroneal microneurography) in 5 healthy humans under conditions of matched tidal volume, breathing frequency, and end-tidal CO2, but varying respiratory motor output as follows(1) passive positive pressure mechanical ventilation, (2) voluntary hyperventilation, (3) assisted mechanical ventilation that required the subject to generate −2.5 cm H2O to trigger each positive pressure breath, and (4) added inspiratory resistance. Spectral analyses showed marked respiratory periodicities in MSNA; however, the amplitude of the peak power was not changed with changing inspiratory effort. Time domain analyses showed that maximum MSNA always occurred at end expiration (25% to 30% of total activity) and minimum activity at end inspiration (2% to 3% of total activity), and the amplitude of the variation was not different among conditions despite marked changes in respiratory motor output. Furthermore, qualitative changes in intrathoracic pressure were without influence on the respiratory modulation of MSNA. In all conditions, within-breath changes in MSNA were inversely related to small changes in diastolic pressure (1 to 3 mm Hg), suggesting that respiratory rhythmicity in MSNA was secondary to loading/unloading of carotid sinus baroreceptors. Furthermore, at any given diastolic pressure, within-breath MSNA varied inversely with lung volume, demonstrating an additional influence of lung inflation feedback on sympathetic discharge. Our data provide evidence against a significant effect of respiratory motor output on the within-breath modulation of MSNA and suggest that feedback from baroreceptors and pulmonary stretch receptors are the dominant determinants of the respiratory modulation of MSNA in the intact human. |
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Spectral analyses showed marked respiratory periodicities in MSNA; however, the amplitude of the peak power was not changed with changing inspiratory effort. Time domain analyses showed that maximum MSNA always occurred at end expiration (25% to 30% of total activity) and minimum activity at end inspiration (2% to 3% of total activity), and the amplitude of the variation was not different among conditions despite marked changes in respiratory motor output. Furthermore, qualitative changes in intrathoracic pressure were without influence on the respiratory modulation of MSNA. In all conditions, within-breath changes in MSNA were inversely related to small changes in diastolic pressure (1 to 3 mm Hg), suggesting that respiratory rhythmicity in MSNA was secondary to loading/unloading of carotid sinus baroreceptors. Furthermore, at any given diastolic pressure, within-breath MSNA varied inversely with lung volume, demonstrating an additional influence of lung inflation feedback on sympathetic discharge. Our data provide evidence against a significant effect of respiratory motor output on the within-breath modulation of MSNA and suggest that feedback from baroreceptors and pulmonary stretch receptors are the dominant determinants of the respiratory modulation of MSNA in the intact human.</description><identifier>ISSN: 0009-7330</identifier><identifier>EISSN: 1524-4571</identifier><identifier>DOI: 10.1161/01.res.85.5.457</identifier><identifier>PMID: 10473675</identifier><identifier>CODEN: CIRUAL</identifier><language>eng</language><publisher>Hagerstown, MD: American Heart Association, Inc</publisher><subject>Action Potentials ; Adult ; Biological and medical sciences ; Brain Stem - physiology ; Cardiorespiratory control. Arterial mecano- and chemoreceptor ; Carotid Sinus - physiology ; Diastole ; Feedback ; Fundamental and applied biological sciences. Psychology ; Humans ; Hyperventilation - physiopathology ; Inhalation - physiology ; Lung - physiology ; Lung Volume Measurements ; Male ; Middle Aged ; Muscle, Skeletal - innervation ; Periodicity ; Peroneal Nerve - physiology ; Phrenic Nerve - physiology ; Positive-Pressure Respiration ; Pressoreceptors - physiology ; Pressure ; Respiration, Artificial ; Respiratory Muscles - physiology ; Space life sciences ; Sympathetic Nervous System - physiology ; Vertebrates: respiratory system</subject><ispartof>Circulation research, 1999-09, Vol.85 (5), p.457-469</ispartof><rights>1999 American Heart Association, Inc.</rights><rights>1999 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Sep 3, 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5838-99ff68e04eb8ac6c20d613cef3aa34482287a93a6965cec4525eacdd2961f2563</citedby><cites>FETCH-LOGICAL-c5838-99ff68e04eb8ac6c20d613cef3aa34482287a93a6965cec4525eacdd2961f2563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,3688,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1963876$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10473675$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>St. Croix, Claudette M</creatorcontrib><creatorcontrib>Satoh, Makoto</creatorcontrib><creatorcontrib>Morgan, Barbara J</creatorcontrib><creatorcontrib>Skatrud, James B</creatorcontrib><creatorcontrib>Dempsey, Jerome A</creatorcontrib><title>Role of Respiratory Motor Output in Within-Breath Modulation of Muscle Sympathetic Nerve Activity in Humans</title><title>Circulation research</title><addtitle>Circ Res</addtitle><description>We measured muscle sympathetic nerve activity (MSNA, peroneal microneurography) in 5 healthy humans under conditions of matched tidal volume, breathing frequency, and end-tidal CO2, but varying respiratory motor output as follows(1) passive positive pressure mechanical ventilation, (2) voluntary hyperventilation, (3) assisted mechanical ventilation that required the subject to generate −2.5 cm H2O to trigger each positive pressure breath, and (4) added inspiratory resistance. Spectral analyses showed marked respiratory periodicities in MSNA; however, the amplitude of the peak power was not changed with changing inspiratory effort. Time domain analyses showed that maximum MSNA always occurred at end expiration (25% to 30% of total activity) and minimum activity at end inspiration (2% to 3% of total activity), and the amplitude of the variation was not different among conditions despite marked changes in respiratory motor output. Furthermore, qualitative changes in intrathoracic pressure were without influence on the respiratory modulation of MSNA. In all conditions, within-breath changes in MSNA were inversely related to small changes in diastolic pressure (1 to 3 mm Hg), suggesting that respiratory rhythmicity in MSNA was secondary to loading/unloading of carotid sinus baroreceptors. Furthermore, at any given diastolic pressure, within-breath MSNA varied inversely with lung volume, demonstrating an additional influence of lung inflation feedback on sympathetic discharge. Our data provide evidence against a significant effect of respiratory motor output on the within-breath modulation of MSNA and suggest that feedback from baroreceptors and pulmonary stretch receptors are the dominant determinants of the respiratory modulation of MSNA in the intact human.</description><subject>Action Potentials</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Brain Stem - physiology</subject><subject>Cardiorespiratory control. Arterial mecano- and chemoreceptor</subject><subject>Carotid Sinus - physiology</subject><subject>Diastole</subject><subject>Feedback</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Hyperventilation - physiopathology</subject><subject>Inhalation - physiology</subject><subject>Lung - physiology</subject><subject>Lung Volume Measurements</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle, Skeletal - innervation</subject><subject>Periodicity</subject><subject>Peroneal Nerve - physiology</subject><subject>Phrenic Nerve - physiology</subject><subject>Positive-Pressure Respiration</subject><subject>Pressoreceptors - physiology</subject><subject>Pressure</subject><subject>Respiration, Artificial</subject><subject>Respiratory Muscles - physiology</subject><subject>Space life sciences</subject><subject>Sympathetic Nervous System - physiology</subject><subject>Vertebrates: respiratory system</subject><issn>0009-7330</issn><issn>1524-4571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1rFEEQhgdRzCZ69iaDiLeZ9Pd0H2OIRkgMbBSPTaenhu1kZnrTHwn779PDLiieqqh66qXqrar6gFGLscCnCLcBYit5y1vGu1fVCnPCmpLi19UKIaSajlJ0VB3HeI8QZpSot9URRqyjouOr6mHtR6j9UK8hbl0wyYddfe1LqG9y2uZUu7n-49LGzc3XACZtSrfPo0nOz8vcdY62KNzupm1pQnK2_gnhCeozm9yTS7tF4DJPZo7vqjeDGSO8P8ST6ve3i1_nl83Vzfcf52dXjeWSykapYRASEIM7aaywBPUCUwsDNYYyJgmRnVHUCCW4Bcs44WBs3xMl8EC4oCfVl73uNvjHDDHpyUUL42hm8DnqDiFCBOoK-Ok_8N7nMJfdNMGEFSslLtDpHrLBxxhg0NvgJhN2GiO9PEEjrNcXt1pyzXVxvkx8PMjmuwn6f_i96wX4fABMtGYcgpmti385JajsljvYHnv2Y4IQH8b8DEFvwIxpo8tzEUWYNFgphVTJm6Uk6QtAVZ8E</recordid><startdate>19990903</startdate><enddate>19990903</enddate><creator>St. Croix, Claudette M</creator><creator>Satoh, Makoto</creator><creator>Morgan, Barbara J</creator><creator>Skatrud, James B</creator><creator>Dempsey, Jerome A</creator><general>American Heart Association, Inc</general><general>Lippincott</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>19990903</creationdate><title>Role of Respiratory Motor Output in Within-Breath Modulation of Muscle Sympathetic Nerve Activity in Humans</title><author>St. Croix, Claudette M ; Satoh, Makoto ; Morgan, Barbara J ; Skatrud, James B ; Dempsey, Jerome A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5838-99ff68e04eb8ac6c20d613cef3aa34482287a93a6965cec4525eacdd2961f2563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Action Potentials</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Brain Stem - physiology</topic><topic>Cardiorespiratory control. Arterial mecano- and chemoreceptor</topic><topic>Carotid Sinus - physiology</topic><topic>Diastole</topic><topic>Feedback</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Hyperventilation - physiopathology</topic><topic>Inhalation - physiology</topic><topic>Lung - physiology</topic><topic>Lung Volume Measurements</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle, Skeletal - innervation</topic><topic>Periodicity</topic><topic>Peroneal Nerve - physiology</topic><topic>Phrenic Nerve - physiology</topic><topic>Positive-Pressure Respiration</topic><topic>Pressoreceptors - physiology</topic><topic>Pressure</topic><topic>Respiration, Artificial</topic><topic>Respiratory Muscles - physiology</topic><topic>Space life sciences</topic><topic>Sympathetic Nervous System - physiology</topic><topic>Vertebrates: respiratory system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>St. Croix, Claudette M</creatorcontrib><creatorcontrib>Satoh, Makoto</creatorcontrib><creatorcontrib>Morgan, Barbara J</creatorcontrib><creatorcontrib>Skatrud, James B</creatorcontrib><creatorcontrib>Dempsey, Jerome A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>St. Croix, Claudette M</au><au>Satoh, Makoto</au><au>Morgan, Barbara J</au><au>Skatrud, James B</au><au>Dempsey, Jerome A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Respiratory Motor Output in Within-Breath Modulation of Muscle Sympathetic Nerve Activity in Humans</atitle><jtitle>Circulation research</jtitle><addtitle>Circ Res</addtitle><date>1999-09-03</date><risdate>1999</risdate><volume>85</volume><issue>5</issue><spage>457</spage><epage>469</epage><pages>457-469</pages><issn>0009-7330</issn><eissn>1524-4571</eissn><coden>CIRUAL</coden><abstract>We measured muscle sympathetic nerve activity (MSNA, peroneal microneurography) in 5 healthy humans under conditions of matched tidal volume, breathing frequency, and end-tidal CO2, but varying respiratory motor output as follows(1) passive positive pressure mechanical ventilation, (2) voluntary hyperventilation, (3) assisted mechanical ventilation that required the subject to generate −2.5 cm H2O to trigger each positive pressure breath, and (4) added inspiratory resistance. Spectral analyses showed marked respiratory periodicities in MSNA; however, the amplitude of the peak power was not changed with changing inspiratory effort. Time domain analyses showed that maximum MSNA always occurred at end expiration (25% to 30% of total activity) and minimum activity at end inspiration (2% to 3% of total activity), and the amplitude of the variation was not different among conditions despite marked changes in respiratory motor output. Furthermore, qualitative changes in intrathoracic pressure were without influence on the respiratory modulation of MSNA. In all conditions, within-breath changes in MSNA were inversely related to small changes in diastolic pressure (1 to 3 mm Hg), suggesting that respiratory rhythmicity in MSNA was secondary to loading/unloading of carotid sinus baroreceptors. Furthermore, at any given diastolic pressure, within-breath MSNA varied inversely with lung volume, demonstrating an additional influence of lung inflation feedback on sympathetic discharge. Our data provide evidence against a significant effect of respiratory motor output on the within-breath modulation of MSNA and suggest that feedback from baroreceptors and pulmonary stretch receptors are the dominant determinants of the respiratory modulation of MSNA in the intact human.</abstract><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>10473675</pmid><doi>10.1161/01.res.85.5.457</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Action Potentials Adult Biological and medical sciences Brain Stem - physiology Cardiorespiratory control. Arterial mecano- and chemoreceptor Carotid Sinus - physiology Diastole Feedback Fundamental and applied biological sciences. Psychology Humans Hyperventilation - physiopathology Inhalation - physiology Lung - physiology Lung Volume Measurements Male Middle Aged Muscle, Skeletal - innervation Periodicity Peroneal Nerve - physiology Phrenic Nerve - physiology Positive-Pressure Respiration Pressoreceptors - physiology Pressure Respiration, Artificial Respiratory Muscles - physiology Space life sciences Sympathetic Nervous System - physiology Vertebrates: respiratory system |
title | Role of Respiratory Motor Output in Within-Breath Modulation of Muscle Sympathetic Nerve Activity in Humans |
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