Protein L-dopa as an index of hydroxyl radical attack on protein tyrosine

It is widely believed that hydroxyl radicals generated in vivo contribute to damage to macromolecules, such as proteins and DNA. We evaluated methodology based on the transformation of protein tyrosine to L-Dopa, via aromatic ring hydroxylation, as an index of hydroxyl radical attack on proteins. Th...

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Veröffentlicht in:	Analytical biochemistry 1998-10, Vol.263 (2), p.232-239
Hauptverfasser:	Cohen, G, Yakushin, S, Dembiec-Cohen, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromatography, High Pressure Liquid Hydroxyl Radical Hydroxylation Levodopa - metabolism Rats Tyrosine - metabolism
Online-Zugang:	Volltext
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