Inhibitory Mechanism of Serpins:  Loop Insertion Forces Acylation of Plasminogen Activator by Plasminogen Activator Inhibitor-1

Serpin inhibitors are believed to form an acyl enzyme intermediate with their target proteinases which is stabilized through insertion of the enzyme-linked part of the reactive center loop (RCL) as strand 4 in β-sheet A of the inhibitor. To test critically the role and timing of these steps in the r...

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