CD40 is functionally expressed on human breast carcinomas : Variable inducibility by cytokines and enhancement of Fas-mediated apoptosis
The CD40 molecule, a member of the TNF receptor gene family, has been intensively studied with respect to regulation of B cell proliferation and survival. Although CD40 is also expressed on carcinoma cell lines, information concerning the biological function of CD40 on cells of epithelial origin is...
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| Veröffentlicht in: | Breast cancer research and treatment 1998-07, Vol.50 (1), p.27-36 |
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| creator | WINGETT, D. G VESTAL, R. E FORCIER, K HADJOKAS, N NIELSON, C. P |
| description | The CD40 molecule, a member of the TNF receptor gene family, has been intensively studied with respect to regulation of B cell proliferation and survival. Although CD40 is also expressed on carcinoma cell lines, information concerning the biological function of CD40 on cells of epithelial origin is limited. In this study we detected constitutive CD40 on human breast carcinoma cell lines and an increase in CD40 expression following treatment with cytokines IL-1alpha and IFN-gamma. CD40 ligation was also found to increase MHC II expression in cells pretreated with IFN-gamma. In contrast to normal B cells, where CD40 signaling provides a potent survival signal, we observed that CD40 ligation in breast carcinoma cells results in growth inhibition and enhanced susceptibility to Fas-mediated apoptosis. Enhanced apoptosis appears to be attributable, at least in part, to an up-regulation of Fas expression caused by CD40 ligation. These results suggest a potentially important role for CD40 in breast tumor biology. |
| doi_str_mv | 10.1023/a:1006012607452 |
| format | Article |
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Enhanced apoptosis appears to be attributable, at least in part, to an up-regulation of Fas expression caused by CD40 ligation. These results suggest a potentially important role for CD40 in breast tumor biology.</description><identifier>ISSN: 0167-6806</identifier><identifier>EISSN: 1573-7217</identifier><identifier>DOI: 10.1023/a:1006012607452</identifier><identifier>PMID: 9802617</identifier><identifier>CODEN: BCTRD6</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Antineoplastic Agents - pharmacology ; Apoptosis ; Apoptosis - drug effects ; Biological and medical sciences ; Breast cancer ; Breast Neoplasms - drug therapy ; Breast Neoplasms - immunology ; Cancer research ; CD40 Antigens - biosynthesis ; CD40 Antigens - drug effects ; Cells ; fas Receptor - metabolism ; Female ; Flow Cytometry ; Gene Expression Regulation, Neoplastic - drug effects ; Gynecology. Andrology. 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| identifier | ISSN: 0167-6806 |
| ispartof | Breast cancer research and treatment, 1998-07, Vol.50 (1), p.27-36 |
| issn | 0167-6806 1573-7217 |
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| subjects | Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Biological and medical sciences Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - immunology Cancer research CD40 Antigens - biosynthesis CD40 Antigens - drug effects Cells fas Receptor - metabolism Female Flow Cytometry Gene Expression Regulation, Neoplastic - drug effects Gynecology. Andrology. Obstetrics Humans Interferon-gamma - pharmacology Interleukin-1 - pharmacology Mammary gland diseases Medical sciences Signal Transduction - drug effects Tumor Cells, Cultured Tumors Up-Regulation - drug effects |
| title | CD40 is functionally expressed on human breast carcinomas : Variable inducibility by cytokines and enhancement of Fas-mediated apoptosis |
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