A comparison of the enantioselectivities of human deoxycytidine kinase and human cytidine deaminase

The stereoselectivities of recombinant human deoxycytidine kinase (EC 2. 7.1.74) (dCK) and of recombinant human cytidine deaminase (EC 3.5.4.5) (CDA) were investigated with respect to a series of cytidine analogs, most of them having the unnatural l-stereochemistry. The enantioselectivity of dCK was...

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Veröffentlicht in:	Biochemical pharmacology 1998-11, Vol.56 (9), p.1237-1242
Hauptverfasser:	Shafiee, Manijeh, Griffon, Jean-François, Gosselin, Gilles, Cambi, Alessandra, Vincenzetti, Silvia, Vita, Alberto, Eriksson, Staffan, Imbach, Jean-Louis, Maury, Georges
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antineoplastic agents Antiviral agents Antiviral Agents - metabolism Biological and medical sciences Cytidine - metabolism cytidine deaminase Cytidine Deaminase - metabolism deoxycytidine kinase Deoxycytidine Kinase - metabolism enzyme enantioselectivity General aspects Humans kinetics l-cytidine analogs Medical sciences Pharmacology. Drug treatments Recombinant Proteins Stereoisomerism Structure-Activity Relationship
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