Time-Optimized Carbon-14 Breath Test for Helicobacter Pylori Contamination of the Stomach
PURPOSE:Evidence that Helicobacter pylori plays an important role in peptic ulcer disease has generated intense interest in the development of various screening strategies. H. pylori can be detected high sensitivity and specificity by the noninvasive carbon-14 (C-14) breath test. METHODS:The authors...
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| Veröffentlicht in: | Clinical nuclear medicine 1999-09, Vol.24 (9), p.674-677 |
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| container_title | Clinical nuclear medicine |
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| creator | CAGLAR, MELTEM BELZBERG, ALLAN S SPRUSTON, BARRY SEXSMITH, GEORGE |
| description | PURPOSE:Evidence that Helicobacter pylori plays an important role in peptic ulcer disease has generated intense interest in the development of various screening strategies. H. pylori can be detected high sensitivity and specificity by the noninvasive carbon-14 (C-14) breath test.
METHODS:The authors assessed the cost-effectiveness of screening patients with dyspepsia before endoscopy. Thirty-four patients with dyspepsia were evaluated by the C-14 breath test, and then the authors reevaluated the criteria for the diagnosis of H. pylori. The discrimination obtained by using values of cumulative radioactivity or specific activity of breath samples collected between 10 and 60 minutes were studied.
RESULTS:The main feature of H. pylori colonization in the stomach was a rapid increase of carbon dioxide in expired breath within 10 minutes after oral administration of C-14. Performance of the test was equally excellent for 10-minute values and 60-minute cumulative excretion.
CONCLUSION:The C-14 breath test is a reliable method for diagnosing H. pylori colonization in the stomach, and the accuracy is not compromised by reducing the sample time to maintain better cost-effectiveness and patient acceptance. |
| doi_str_mv | 10.1097/00003072-199909000-00007 |
| format | Article |
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METHODS:The authors assessed the cost-effectiveness of screening patients with dyspepsia before endoscopy. Thirty-four patients with dyspepsia were evaluated by the C-14 breath test, and then the authors reevaluated the criteria for the diagnosis of H. pylori. The discrimination obtained by using values of cumulative radioactivity or specific activity of breath samples collected between 10 and 60 minutes were studied.
RESULTS:The main feature of H. pylori colonization in the stomach was a rapid increase of carbon dioxide in expired breath within 10 minutes after oral administration of C-14. Performance of the test was equally excellent for 10-minute values and 60-minute cumulative excretion.
CONCLUSION:The C-14 breath test is a reliable method for diagnosing H. pylori colonization in the stomach, and the accuracy is not compromised by reducing the sample time to maintain better cost-effectiveness and patient acceptance.</description><identifier>ISSN: 0363-9762</identifier><identifier>EISSN: 1536-0229</identifier><identifier>DOI: 10.1097/00003072-199909000-00007</identifier><identifier>PMID: 10478743</identifier><identifier>CODEN: CNMEDK</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott Williams & Wilkins, Inc</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Breath Tests - methods ; Carbon Radioisotopes ; Cost-Benefit Analysis ; Digestion. Liver. Biliary tract. Spleen. Pancreas ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Helicobacter Infections - diagnosis ; Helicobacter pylori - isolation & purification ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Radionuclide investigations ; Retrospective Studies ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><ispartof>Clinical nuclear medicine, 1999-09, Vol.24 (9), p.674-677</ispartof><rights>1999 Lippincott Williams & Wilkins, Inc.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3857-ed1611a2f71cd9b92ff9deb037554ad35ed44d328c606a6ed6faeb3f375b0af63</citedby><cites>FETCH-LOGICAL-c3857-ed1611a2f71cd9b92ff9deb037554ad35ed44d328c606a6ed6faeb3f375b0af63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1947796$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10478743$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CAGLAR, MELTEM</creatorcontrib><creatorcontrib>BELZBERG, ALLAN S</creatorcontrib><creatorcontrib>SPRUSTON, BARRY</creatorcontrib><creatorcontrib>SEXSMITH, GEORGE</creatorcontrib><title>Time-Optimized Carbon-14 Breath Test for Helicobacter Pylori Contamination of the Stomach</title><title>Clinical nuclear medicine</title><addtitle>Clin Nucl Med</addtitle><description>PURPOSE:Evidence that Helicobacter pylori plays an important role in peptic ulcer disease has generated intense interest in the development of various screening strategies. H. pylori can be detected high sensitivity and specificity by the noninvasive carbon-14 (C-14) breath test.
METHODS:The authors assessed the cost-effectiveness of screening patients with dyspepsia before endoscopy. Thirty-four patients with dyspepsia were evaluated by the C-14 breath test, and then the authors reevaluated the criteria for the diagnosis of H. pylori. The discrimination obtained by using values of cumulative radioactivity or specific activity of breath samples collected between 10 and 60 minutes were studied.
RESULTS:The main feature of H. pylori colonization in the stomach was a rapid increase of carbon dioxide in expired breath within 10 minutes after oral administration of C-14. Performance of the test was equally excellent for 10-minute values and 60-minute cumulative excretion.
CONCLUSION:The C-14 breath test is a reliable method for diagnosing H. pylori colonization in the stomach, and the accuracy is not compromised by reducing the sample time to maintain better cost-effectiveness and patient acceptance.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Breath Tests - methods</subject><subject>Carbon Radioisotopes</subject><subject>Cost-Benefit Analysis</subject><subject>Digestion. Liver. Biliary tract. Spleen. Pancreas</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Helicobacter Infections - diagnosis</subject><subject>Helicobacter pylori - isolation & purification</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Radionuclide investigations</subject><subject>Retrospective Studies</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><issn>0363-9762</issn><issn>1536-0229</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc2OFCEURonROO3oKxgWxh0KBQXFUjujYzLJmNguXBGKuqRQqmiBzmR8emm7_dnIhnA59_LlgBBm9BWjWr2mbXGqOsK01lS3EzmW1AO0YT2XhHadfog2lEtOtJLdBXpSyldKmWRSPEYXjAo1KME36MsuLEBu9zUs4QdMeGvzmFbCBH6bwdYZ76BU7FPG1xCDS6N1FTL-eB9TDnib1mqXsNoa0oqTx3UG_Kmmxbr5KXrkbSzw7Lxfos_vrnbba3Jz-_7D9s0NcXzoFYGphWK284q5SY-6815PMFKu-l7YifcwCTHxbnCSSithkt7CyH27H6n1kl-il6e5-5y-H1pas4TiIEa7QjoUoyjt6MD7Bg4n0OVUSgZv9jksNt8bRs1Rq_mt1fzR-qukWuvz8xuHcYHpn8aTxwa8OAO2OBt9tqsL5S-nhVL6mFWcsLsUm8byLR7uIJsZbKyz-d-v8p_R8o8i</recordid><startdate>199909</startdate><enddate>199909</enddate><creator>CAGLAR, MELTEM</creator><creator>BELZBERG, ALLAN S</creator><creator>SPRUSTON, BARRY</creator><creator>SEXSMITH, GEORGE</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199909</creationdate><title>Time-Optimized Carbon-14 Breath Test for Helicobacter Pylori Contamination of the Stomach</title><author>CAGLAR, MELTEM ; BELZBERG, ALLAN S ; SPRUSTON, BARRY ; SEXSMITH, GEORGE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3857-ed1611a2f71cd9b92ff9deb037554ad35ed44d328c606a6ed6faeb3f375b0af63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Breath Tests - methods</topic><topic>Carbon Radioisotopes</topic><topic>Cost-Benefit Analysis</topic><topic>Digestion. Liver. Biliary tract. Spleen. Pancreas</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Helicobacter Infections - diagnosis</topic><topic>Helicobacter pylori - isolation & purification</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Radionuclide investigations</topic><topic>Retrospective Studies</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CAGLAR, MELTEM</creatorcontrib><creatorcontrib>BELZBERG, ALLAN S</creatorcontrib><creatorcontrib>SPRUSTON, BARRY</creatorcontrib><creatorcontrib>SEXSMITH, GEORGE</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical nuclear medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CAGLAR, MELTEM</au><au>BELZBERG, ALLAN S</au><au>SPRUSTON, BARRY</au><au>SEXSMITH, GEORGE</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Time-Optimized Carbon-14 Breath Test for Helicobacter Pylori Contamination of the Stomach</atitle><jtitle>Clinical nuclear medicine</jtitle><addtitle>Clin Nucl Med</addtitle><date>1999-09</date><risdate>1999</risdate><volume>24</volume><issue>9</issue><spage>674</spage><epage>677</epage><pages>674-677</pages><issn>0363-9762</issn><eissn>1536-0229</eissn><coden>CNMEDK</coden><abstract>PURPOSE:Evidence that Helicobacter pylori plays an important role in peptic ulcer disease has generated intense interest in the development of various screening strategies. H. pylori can be detected high sensitivity and specificity by the noninvasive carbon-14 (C-14) breath test.
METHODS:The authors assessed the cost-effectiveness of screening patients with dyspepsia before endoscopy. Thirty-four patients with dyspepsia were evaluated by the C-14 breath test, and then the authors reevaluated the criteria for the diagnosis of H. pylori. The discrimination obtained by using values of cumulative radioactivity or specific activity of breath samples collected between 10 and 60 minutes were studied.
RESULTS:The main feature of H. pylori colonization in the stomach was a rapid increase of carbon dioxide in expired breath within 10 minutes after oral administration of C-14. Performance of the test was equally excellent for 10-minute values and 60-minute cumulative excretion.
CONCLUSION:The C-14 breath test is a reliable method for diagnosing H. pylori colonization in the stomach, and the accuracy is not compromised by reducing the sample time to maintain better cost-effectiveness and patient acceptance.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>10478743</pmid><doi>10.1097/00003072-199909000-00007</doi><tpages>4</tpages></addata></record> |
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| ispartof | Clinical nuclear medicine, 1999-09, Vol.24 (9), p.674-677 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Adult Aged Biological and medical sciences Breath Tests - methods Carbon Radioisotopes Cost-Benefit Analysis Digestion. Liver. Biliary tract. Spleen. Pancreas Female Gastroenterology. Liver. Pancreas. Abdomen Helicobacter Infections - diagnosis Helicobacter pylori - isolation & purification Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Other diseases. Semiology Radionuclide investigations Retrospective Studies Stomach. Duodenum. Small intestine. Colon. Rectum. Anus |
| title | Time-Optimized Carbon-14 Breath Test for Helicobacter Pylori Contamination of the Stomach |
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