Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area
Recent studies have reinforced the view that the lateral hypothalamic area (LHA) regulates food intake and body weight. We identified leptin-sensitive neurons in the arcuate nucleus of the hypothalamus (Arc) that innervate the LHA using retrograde tracing with leptin administration. We found that re...
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| Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 1999-08, Vol.23 (4), p.775-786 |
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| container_title | Neuron (Cambridge, Mass.) |
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| creator | Elias, C F Aschkenasi, C Lee, C Kelly, J Ahima, R S Bjorbaek, C Flier, J S Saper, C B Elmquist, J K |
| description | Recent studies have reinforced the view that the lateral hypothalamic area (LHA) regulates food intake and body weight. We identified leptin-sensitive neurons in the arcuate nucleus of the hypothalamus (Arc) that innervate the LHA using retrograde tracing with leptin administration. We found that retrogradely labeled cells in the Arc contained neuropeptide Y (NPY) mRNA or proopiomelanocortin (POMC) mRNA. Following leptin administration, NPY cells in the Arc did not express Fos but expressed suppressor of cytokine signaling-3 (SOCS-3) mRNA. In contrast, leptin induced both Fos and SOCS-3 expression in POMC neurons, many of which also innervated the LHA. These findings suggest that leptin directly and differentially engages NPY and POMC neurons that project to the LHA, linking circulating leptin and neurons that regulate feeding behavior and body weight homeostasis. |
| doi_str_mv | 10.1016/s0896-6273(01)80035-0 |
| format | Article |
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We identified leptin-sensitive neurons in the arcuate nucleus of the hypothalamus (Arc) that innervate the LHA using retrograde tracing with leptin administration. We found that retrogradely labeled cells in the Arc contained neuropeptide Y (NPY) mRNA or proopiomelanocortin (POMC) mRNA. Following leptin administration, NPY cells in the Arc did not express Fos but expressed suppressor of cytokine signaling-3 (SOCS-3) mRNA. In contrast, leptin induced both Fos and SOCS-3 expression in POMC neurons, many of which also innervated the LHA. 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We identified leptin-sensitive neurons in the arcuate nucleus of the hypothalamus (Arc) that innervate the LHA using retrograde tracing with leptin administration. We found that retrogradely labeled cells in the Arc contained neuropeptide Y (NPY) mRNA or proopiomelanocortin (POMC) mRNA. Following leptin administration, NPY cells in the Arc did not express Fos but expressed suppressor of cytokine signaling-3 (SOCS-3) mRNA. In contrast, leptin induced both Fos and SOCS-3 expression in POMC neurons, many of which also innervated the LHA. These findings suggest that leptin directly and differentially engages NPY and POMC neurons that project to the LHA, linking circulating leptin and neurons that regulate feeding behavior and body weight homeostasis.</description><subject>Animals</subject><subject>arcuate nucleus</subject><subject>Arcuate Nucleus of Hypothalamus - cytology</subject><subject>Arcuate Nucleus of Hypothalamus - physiology</subject><subject>Body Weight - physiology</subject><subject>Cell Count</subject><subject>cytokine signalling 3 protein</subject><subject>Eating - physiology</subject><subject>Homeostasis - physiology</subject><subject>Hypothalamic Area, Lateral - cytology</subject><subject>Hypothalamic Area, Lateral - physiology</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization</subject><subject>Leptin</subject><subject>Male</subject><subject>Neural Pathways - cytology</subject><subject>Neural Pathways - physiology</subject><subject>Neurons - physiology</subject><subject>Neuropeptide Y - physiology</subject><subject>Pro-Opiomelanocortin - physiology</subject><subject>Protein Biosynthesis</subject><subject>Proteins - physiology</subject><subject>Proto-Oncogene Proteins c-fos - biosynthesis</subject><subject>Proto-Oncogene Proteins c-fos - genetics</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Repressor Proteins</subject><subject>RNA, Messenger - biosynthesis</subject><subject>RNA, Messenger - genetics</subject><subject>Signal Transduction - physiology</subject><subject>Suppressor of Cytokine Signaling 3 Protein</subject><subject>Suppressor of Cytokine Signaling Proteins</subject><subject>Transcription Factors</subject><issn>0896-6273</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkLtOw0AQRbcA8Qh8AmgrBIVhxq-1SxTxkgJBAgqqZbyeJY4cO-zaRf6emESIjmqk0T13RkeIE4RLBEyvPGR5GqShis4BLzKAKAlgRxz8rvfFofdzAIyTHPfEPkKchWEcHYiPCS-7qpFlZS07brqK6nolHX_2NXXs5dPzu6SmlM_Tx7FsuHdt4-XStXM2a-5Tdq3sZiyHsKNazlbLtptRTYvKSHJMR2LXUu35eDtH4u325nV8H0ymdw_j60lgEsAuUGGRJxARpnFpY2VjNlBgUSjMYyTKmXOyqoDUlqgKSjMMk8IYlRvKwHISjcTZpnf921fPvtOLyhuua2q47b1WACEksfo3iCrKsigdGpNN0LjWe8dWL121ILfSCHrwrl8GwXoQrAH1j3cNa-50e6AvFlz-oTbSo28vJ4Fv</recordid><startdate>19990801</startdate><enddate>19990801</enddate><creator>Elias, C F</creator><creator>Aschkenasi, C</creator><creator>Lee, C</creator><creator>Kelly, J</creator><creator>Ahima, R S</creator><creator>Bjorbaek, C</creator><creator>Flier, J S</creator><creator>Saper, C B</creator><creator>Elmquist, J K</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19990801</creationdate><title>Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area</title><author>Elias, C F ; 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We identified leptin-sensitive neurons in the arcuate nucleus of the hypothalamus (Arc) that innervate the LHA using retrograde tracing with leptin administration. We found that retrogradely labeled cells in the Arc contained neuropeptide Y (NPY) mRNA or proopiomelanocortin (POMC) mRNA. Following leptin administration, NPY cells in the Arc did not express Fos but expressed suppressor of cytokine signaling-3 (SOCS-3) mRNA. In contrast, leptin induced both Fos and SOCS-3 expression in POMC neurons, many of which also innervated the LHA. These findings suggest that leptin directly and differentially engages NPY and POMC neurons that project to the LHA, linking circulating leptin and neurons that regulate feeding behavior and body weight homeostasis.</abstract><cop>United States</cop><pmid>10482243</pmid><doi>10.1016/s0896-6273(01)80035-0</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals arcuate nucleus Arcuate Nucleus of Hypothalamus - cytology Arcuate Nucleus of Hypothalamus - physiology Body Weight - physiology Cell Count cytokine signalling 3 protein Eating - physiology Homeostasis - physiology Hypothalamic Area, Lateral - cytology Hypothalamic Area, Lateral - physiology Immunohistochemistry In Situ Hybridization Leptin Male Neural Pathways - cytology Neural Pathways - physiology Neurons - physiology Neuropeptide Y - physiology Pro-Opiomelanocortin - physiology Protein Biosynthesis Proteins - physiology Proto-Oncogene Proteins c-fos - biosynthesis Proto-Oncogene Proteins c-fos - genetics Rats Rats, Sprague-Dawley Repressor Proteins RNA, Messenger - biosynthesis RNA, Messenger - genetics Signal Transduction - physiology Suppressor of Cytokine Signaling 3 Protein Suppressor of Cytokine Signaling Proteins Transcription Factors |
| title | Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area |
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