Hemoglobins in Togolese Newborns: Hb S, Hb C, Hb Bart's, and α‐Globin Gene Status
The gene frequency of the most important hemoglobin (Hb) abnormalities is reported in a population of 171 Togolese newborns. Hb phenotypes, hematological parameters, and the more frequently described α‐gene deletions were analyzed. Structural abnormalities of β‐globin were observed in 35.7% of the c...
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| Veröffentlicht in: | American journal of hematology 1998-11, Vol.59 (3), p.208-213 |
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| creator | Segbena, Akueté Yvon Prehu, Claude Wajcman, Henri Bardakdjian‐Michau, Josiane Messie, Kodjovi Feteke, Lochina Vovor, Anne David, Mireille Feingold, Josué Galacteros, Frédéric |
| description | The gene frequency of the most important hemoglobin (Hb) abnormalities is reported in a population of 171 Togolese newborns. Hb phenotypes, hematological parameters, and the more frequently described α‐gene deletions were analyzed. Structural abnormalities of β‐globin were observed in 35.7% of the children with a gene frequency of 0.105 for βS and 0.091 for βC. The frequency of the different α‐globin genotypes was αα/ = 0.71, −α/ = 0.28, and ααα/ = 0.01. All of the individuals homozygous for the −α/ genotypes, and most of the heterozygous individuals, carried Hb Bart's. Within the αα/αα and the −α/αα groups, several individuals with or without Hb Bart's were found; they did not differ from the others by their red blood cell (RBC) parameters but by their levels of fetal hemoglobin (Hb F). The African α2 polymorphism marker, characterized by the replacement of G by TCGGCCC at position 7238 (EMBL HSHBA4, 1993) and of T 7174 by G, was found in 21 newborns. The mean value of Hb F was calculated for each genotype, the mean Gγ percentage was 69.4 ± 4.0%, and the gene frequency of the AγTmarker was 0.10; this marker was linked to the normal β‐globin cluster. Am. J. Hematol. 59:208–213, 1998. © 1998 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1096-8652(199811)59:3<208::AID-AJH5>3.0.CO;2-R |
| format | Article |
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Hb phenotypes, hematological parameters, and the more frequently described α‐gene deletions were analyzed. Structural abnormalities of β‐globin were observed in 35.7% of the children with a gene frequency of 0.105 for βS and 0.091 for βC. The frequency of the different α‐globin genotypes was αα/ = 0.71, −α/ = 0.28, and ααα/ = 0.01. All of the individuals homozygous for the −α/ genotypes, and most of the heterozygous individuals, carried Hb Bart's. Within the αα/αα and the −α/αα groups, several individuals with or without Hb Bart's were found; they did not differ from the others by their red blood cell (RBC) parameters but by their levels of fetal hemoglobin (Hb F). The African α2 polymorphism marker, characterized by the replacement of G by TCGGCCC at position 7238 (EMBL HSHBA4, 1993) and of T 7174 by G, was found in 21 newborns. The mean value of Hb F was calculated for each genotype, the mean Gγ percentage was 69.4 ± 4.0%, and the gene frequency of the AγTmarker was 0.10; this marker was linked to the normal β‐globin cluster. Am. J. Hematol. 59:208–213, 1998. © 1998 Wiley‐Liss, Inc.</description><identifier>ISSN: 0361-8609</identifier><identifier>EISSN: 1096-8652</identifier><identifier>DOI: 10.1002/(SICI)1096-8652(199811)59:3<208::AID-AJH5>3.0.CO;2-R</identifier><identifier>PMID: 9798658</identifier><identifier>CODEN: AJHEDD</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Anemias. Hemoglobinopathies ; Biological and medical sciences ; Blood Cell Count ; Diseases of red blood cells ; Female ; Fetal Blood - chemistry ; Fetal Hemoglobin - analysis ; Fetal Hemoglobin - genetics ; Gene Deletion ; Gene Dosage ; Gene Frequency ; Genetic Markers - genetics ; Globins - genetics ; Hb Bart's ; Hb F ; Hematologic and hematopoietic diseases ; Hemoglobin C - analysis ; Hemoglobin C - genetics ; Hemoglobin, Sickle - analysis ; Hemoglobin, Sickle - genetics ; Hemoglobins, Abnormal - analysis ; Hemoglobins, Abnormal - genetics ; Heterozygote ; Homozygote ; Humans ; Infant, Newborn ; Male ; Medical sciences ; Phenotype ; Polymorphism, Genetic ; Togo ; Tropical medicine ; α‐globin genotypes</subject><ispartof>American journal of hematology, 1998-11, Vol.59 (3), p.208-213</ispartof><rights>Copyright © 1998 Wiley‐Liss, Inc.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3805-a67ed9e234758140d8e65b42480ddd3577c77b9c58a3628db630e55d7f0692053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291096-8652%28199811%2959%3A3%3C208%3A%3AAID-AJH5%3E3.0.CO%3B2-R$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291096-8652%28199811%2959%3A3%3C208%3A%3AAID-AJH5%3E3.0.CO%3B2-R$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,1428,27905,27906,45555,45556,46390,46814</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2420603$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9798658$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Segbena, Akueté Yvon</creatorcontrib><creatorcontrib>Prehu, Claude</creatorcontrib><creatorcontrib>Wajcman, Henri</creatorcontrib><creatorcontrib>Bardakdjian‐Michau, Josiane</creatorcontrib><creatorcontrib>Messie, Kodjovi</creatorcontrib><creatorcontrib>Feteke, Lochina</creatorcontrib><creatorcontrib>Vovor, Anne</creatorcontrib><creatorcontrib>David, Mireille</creatorcontrib><creatorcontrib>Feingold, Josué</creatorcontrib><creatorcontrib>Galacteros, Frédéric</creatorcontrib><title>Hemoglobins in Togolese Newborns: Hb S, Hb C, Hb Bart's, and α‐Globin Gene Status</title><title>American journal of hematology</title><addtitle>Am J Hematol</addtitle><description>The gene frequency of the most important hemoglobin (Hb) abnormalities is reported in a population of 171 Togolese newborns. Hb phenotypes, hematological parameters, and the more frequently described α‐gene deletions were analyzed. Structural abnormalities of β‐globin were observed in 35.7% of the children with a gene frequency of 0.105 for βS and 0.091 for βC. The frequency of the different α‐globin genotypes was αα/ = 0.71, −α/ = 0.28, and ααα/ = 0.01. All of the individuals homozygous for the −α/ genotypes, and most of the heterozygous individuals, carried Hb Bart's. Within the αα/αα and the −α/αα groups, several individuals with or without Hb Bart's were found; they did not differ from the others by their red blood cell (RBC) parameters but by their levels of fetal hemoglobin (Hb F). The African α2 polymorphism marker, characterized by the replacement of G by TCGGCCC at position 7238 (EMBL HSHBA4, 1993) and of T 7174 by G, was found in 21 newborns. The mean value of Hb F was calculated for each genotype, the mean Gγ percentage was 69.4 ± 4.0%, and the gene frequency of the AγTmarker was 0.10; this marker was linked to the normal β‐globin cluster. Am. J. Hematol. 59:208–213, 1998. © 1998 Wiley‐Liss, Inc.</description><subject>Anemias. Hemoglobinopathies</subject><subject>Biological and medical sciences</subject><subject>Blood Cell Count</subject><subject>Diseases of red blood cells</subject><subject>Female</subject><subject>Fetal Blood - chemistry</subject><subject>Fetal Hemoglobin - analysis</subject><subject>Fetal Hemoglobin - genetics</subject><subject>Gene Deletion</subject><subject>Gene Dosage</subject><subject>Gene Frequency</subject><subject>Genetic Markers - genetics</subject><subject>Globins - genetics</subject><subject>Hb Bart's</subject><subject>Hb F</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hemoglobin C - analysis</subject><subject>Hemoglobin C - genetics</subject><subject>Hemoglobin, Sickle - analysis</subject><subject>Hemoglobin, Sickle - genetics</subject><subject>Hemoglobins, Abnormal - analysis</subject><subject>Hemoglobins, Abnormal - genetics</subject><subject>Heterozygote</subject><subject>Homozygote</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Phenotype</subject><subject>Polymorphism, Genetic</subject><subject>Togo</subject><subject>Tropical medicine</subject><subject>α‐globin genotypes</subject><issn>0361-8609</issn><issn>1096-8652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkFFuEzEQhi0EKmnhCEh-QLSVumFsr712qCqlCyRBFZGa8Dzy7jrVos1uWSeq-sYRuEovwiF6knqTKDyAxMvYo_nnn18fIecM-gyAvz-ZTdLJKQOjIq0kP2HGaMZOpRmIcw56MBhOPkbDL2N5IfrQT6cfeHT9jPT2C89JD4Ri4Q_mJTn0_jsAY7GGA3JgEhMkukfmY7dsbqomK2tPy5rOm5umct7Rr-4ua9raD-g4o7Ozrqabemnb1bE_o7Yu6O-Hx5-_RpttOnK1o7OVXa39K_JiYSvvXu_eI_Lt86d5Oo6upqNJOryKcqFBRlYlrjCOiziRmsVQaKdkFvMQsSgKIZMkT5LM5FJbobguMiXASVkkC1CGgxRH5N3W97ZtfqydX-Gy9LmrKlu7Zu0xCRghViYI51th3jbet26Bt225tO09MsAONmIHGzt22LHDLWyUBgUG2IgBNnawQw-YTpHjdbB9s7u_zpau2Jvu6Ib5293c-txWi9bWeen3Mh5zUCD-pLsrK3f_V7T_JPtHsE0vngCV0qPE</recordid><startdate>199811</startdate><enddate>199811</enddate><creator>Segbena, Akueté Yvon</creator><creator>Prehu, Claude</creator><creator>Wajcman, Henri</creator><creator>Bardakdjian‐Michau, Josiane</creator><creator>Messie, Kodjovi</creator><creator>Feteke, Lochina</creator><creator>Vovor, Anne</creator><creator>David, Mireille</creator><creator>Feingold, Josué</creator><creator>Galacteros, Frédéric</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199811</creationdate><title>Hemoglobins in Togolese Newborns: Hb S, Hb C, Hb Bart's, and α‐Globin Gene Status</title><author>Segbena, Akueté Yvon ; Prehu, Claude ; Wajcman, Henri ; Bardakdjian‐Michau, Josiane ; Messie, Kodjovi ; Feteke, Lochina ; Vovor, Anne ; David, Mireille ; Feingold, Josué ; Galacteros, Frédéric</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3805-a67ed9e234758140d8e65b42480ddd3577c77b9c58a3628db630e55d7f0692053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Anemias. Hemoglobinopathies</topic><topic>Biological and medical sciences</topic><topic>Blood Cell Count</topic><topic>Diseases of red blood cells</topic><topic>Female</topic><topic>Fetal Blood - chemistry</topic><topic>Fetal Hemoglobin - analysis</topic><topic>Fetal Hemoglobin - genetics</topic><topic>Gene Deletion</topic><topic>Gene Dosage</topic><topic>Gene Frequency</topic><topic>Genetic Markers - genetics</topic><topic>Globins - genetics</topic><topic>Hb Bart's</topic><topic>Hb F</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hemoglobin C - analysis</topic><topic>Hemoglobin C - genetics</topic><topic>Hemoglobin, Sickle - analysis</topic><topic>Hemoglobin, Sickle - genetics</topic><topic>Hemoglobins, Abnormal - analysis</topic><topic>Hemoglobins, Abnormal - genetics</topic><topic>Heterozygote</topic><topic>Homozygote</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Phenotype</topic><topic>Polymorphism, Genetic</topic><topic>Togo</topic><topic>Tropical medicine</topic><topic>α‐globin genotypes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Segbena, Akueté Yvon</creatorcontrib><creatorcontrib>Prehu, Claude</creatorcontrib><creatorcontrib>Wajcman, Henri</creatorcontrib><creatorcontrib>Bardakdjian‐Michau, Josiane</creatorcontrib><creatorcontrib>Messie, Kodjovi</creatorcontrib><creatorcontrib>Feteke, Lochina</creatorcontrib><creatorcontrib>Vovor, Anne</creatorcontrib><creatorcontrib>David, Mireille</creatorcontrib><creatorcontrib>Feingold, Josué</creatorcontrib><creatorcontrib>Galacteros, Frédéric</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Segbena, Akueté Yvon</au><au>Prehu, Claude</au><au>Wajcman, Henri</au><au>Bardakdjian‐Michau, Josiane</au><au>Messie, Kodjovi</au><au>Feteke, Lochina</au><au>Vovor, Anne</au><au>David, Mireille</au><au>Feingold, Josué</au><au>Galacteros, Frédéric</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hemoglobins in Togolese Newborns: Hb S, Hb C, Hb Bart's, and α‐Globin Gene Status</atitle><jtitle>American journal of hematology</jtitle><addtitle>Am J Hematol</addtitle><date>1998-11</date><risdate>1998</risdate><volume>59</volume><issue>3</issue><spage>208</spage><epage>213</epage><pages>208-213</pages><issn>0361-8609</issn><eissn>1096-8652</eissn><coden>AJHEDD</coden><abstract>The gene frequency of the most important hemoglobin (Hb) abnormalities is reported in a population of 171 Togolese newborns. Hb phenotypes, hematological parameters, and the more frequently described α‐gene deletions were analyzed. Structural abnormalities of β‐globin were observed in 35.7% of the children with a gene frequency of 0.105 for βS and 0.091 for βC. The frequency of the different α‐globin genotypes was αα/ = 0.71, −α/ = 0.28, and ααα/ = 0.01. All of the individuals homozygous for the −α/ genotypes, and most of the heterozygous individuals, carried Hb Bart's. Within the αα/αα and the −α/αα groups, several individuals with or without Hb Bart's were found; they did not differ from the others by their red blood cell (RBC) parameters but by their levels of fetal hemoglobin (Hb F). The African α2 polymorphism marker, characterized by the replacement of G by TCGGCCC at position 7238 (EMBL HSHBA4, 1993) and of T 7174 by G, was found in 21 newborns. The mean value of Hb F was calculated for each genotype, the mean Gγ percentage was 69.4 ± 4.0%, and the gene frequency of the AγTmarker was 0.10; this marker was linked to the normal β‐globin cluster. Am. J. Hematol. 59:208–213, 1998. © 1998 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>9798658</pmid><doi>10.1002/(SICI)1096-8652(199811)59:3<208::AID-AJH5>3.0.CO;2-R</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anemias. Hemoglobinopathies Biological and medical sciences Blood Cell Count Diseases of red blood cells Female Fetal Blood - chemistry Fetal Hemoglobin - analysis Fetal Hemoglobin - genetics Gene Deletion Gene Dosage Gene Frequency Genetic Markers - genetics Globins - genetics Hb Bart's Hb F Hematologic and hematopoietic diseases Hemoglobin C - analysis Hemoglobin C - genetics Hemoglobin, Sickle - analysis Hemoglobin, Sickle - genetics Hemoglobins, Abnormal - analysis Hemoglobins, Abnormal - genetics Heterozygote Homozygote Humans Infant, Newborn Male Medical sciences Phenotype Polymorphism, Genetic Togo Tropical medicine α‐globin genotypes |
| title | Hemoglobins in Togolese Newborns: Hb S, Hb C, Hb Bart's, and α‐Globin Gene Status |
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