Development of hepatocellular carcinoma in a patient with chronic hepatitis C after 6 years of a sustained and complete response to IFN-α
The authors report a rare case of hepatocellular carcinoma (HCC) that developed 6 years after a sustained and complete response to interferon (IFN) therapy for chronic hepatitis C. A 61-year-old Japanese man presented with a mass in the liver that was diagnosed as HCC. Six years earlier he was treat...
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| Veröffentlicht in: | Journal of clinical gastroenterology 1999-09, Vol.29 (2), p.207-209 |
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| container_title | Journal of clinical gastroenterology |
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| creator | YAMAGUCHI, K OMAGARI, K KINOSHITA, H YOSHIOKA, S FURUSU, H TAKESHIMA, F NANASHIMA, A YAMAGUCHI, H KOHNO, S |
| description | The authors report a rare case of hepatocellular carcinoma (HCC) that developed 6 years after a sustained and complete response to interferon (IFN) therapy for chronic hepatitis C. A 61-year-old Japanese man presented with a mass in the liver that was diagnosed as HCC. Six years earlier he was treated with IFN-alpha and responded successfully to therapy, with sustained normalization of serum aminotransferases and eradication of serum hepatitis C virus (HCV)-ribonucleic acid (RNA). HCV-RNA was also not detected in the resected tumorous and nontumorous liver tissues. The findings suggest that all patients with chronic HCV infection should be followed closely for as long as possible for the potential development of HCC even after a complete and sustained response to IFN treatment. |
| doi_str_mv | 10.1097/00004836-199909000-00024 |
| format | Article |
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A 61-year-old Japanese man presented with a mass in the liver that was diagnosed as HCC. Six years earlier he was treated with IFN-alpha and responded successfully to therapy, with sustained normalization of serum aminotransferases and eradication of serum hepatitis C virus (HCV)-ribonucleic acid (RNA). HCV-RNA was also not detected in the resected tumorous and nontumorous liver tissues. The findings suggest that all patients with chronic HCV infection should be followed closely for as long as possible for the potential development of HCC even after a complete and sustained response to IFN treatment.</description><identifier>ISSN: 0192-0790</identifier><identifier>EISSN: 1539-2031</identifier><identifier>DOI: 10.1097/00004836-199909000-00024</identifier><identifier>PMID: 10478890</identifier><identifier>CODEN: JCGADC</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Biological and medical sciences ; Carcinoma, Hepatocellular - etiology ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatitis C, Chronic - complications ; Hepatitis C, Chronic - therapy ; Humans ; Interferon-alpha - therapeutic use ; Liver Neoplasms - etiology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Time Factors ; Tumors</subject><ispartof>Journal of clinical gastroenterology, 1999-09, Vol.29 (2), p.207-209</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-55c23d580ba8a59ffb500b5b41b3cd5d597e5971c3fb584becf8f13e421d28f63</citedby><cites>FETCH-LOGICAL-c340t-55c23d580ba8a59ffb500b5b41b3cd5d597e5971c3fb584becf8f13e421d28f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1928935$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10478890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YAMAGUCHI, K</creatorcontrib><creatorcontrib>OMAGARI, K</creatorcontrib><creatorcontrib>KINOSHITA, H</creatorcontrib><creatorcontrib>YOSHIOKA, S</creatorcontrib><creatorcontrib>FURUSU, H</creatorcontrib><creatorcontrib>TAKESHIMA, F</creatorcontrib><creatorcontrib>NANASHIMA, A</creatorcontrib><creatorcontrib>YAMAGUCHI, H</creatorcontrib><creatorcontrib>KOHNO, S</creatorcontrib><title>Development of hepatocellular carcinoma in a patient with chronic hepatitis C after 6 years of a sustained and complete response to IFN-α</title><title>Journal of clinical gastroenterology</title><addtitle>J Clin Gastroenterol</addtitle><description>The authors report a rare case of hepatocellular carcinoma (HCC) that developed 6 years after a sustained and complete response to interferon (IFN) therapy for chronic hepatitis C. A 61-year-old Japanese man presented with a mass in the liver that was diagnosed as HCC. Six years earlier he was treated with IFN-alpha and responded successfully to therapy, with sustained normalization of serum aminotransferases and eradication of serum hepatitis C virus (HCV)-ribonucleic acid (RNA). HCV-RNA was also not detected in the resected tumorous and nontumorous liver tissues. The findings suggest that all patients with chronic HCV infection should be followed closely for as long as possible for the potential development of HCC even after a complete and sustained response to IFN treatment.</description><subject>Biological and medical sciences</subject><subject>Carcinoma, Hepatocellular - etiology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatitis C, Chronic - complications</subject><subject>Hepatitis C, Chronic - therapy</subject><subject>Humans</subject><subject>Interferon-alpha - therapeutic use</subject><subject>Liver Neoplasms - etiology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Time Factors</subject><subject>Tumors</subject><issn>0192-0790</issn><issn>1539-2031</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkcFu1DAQhi0EotuWV0BzQNwCdhxv7CNaaKlUwYWeo4kz1holcbAdUF-Bt-FF-kx42aUw0mhkzffPyPMzBoK_Edy0b3mJRsttJYwx3JRXVbJunrCNUNJUNZfiKdtwYeqKt4afsfOUvnIuWinFc3YmeNNqbfiG_XxP32kMy0RzhuBgTwvmYGkc1xEjWIzWz2FC8DMglJ4_gD983oPdxzB7e5T47BPsAF2mCFu4J4zpMA8hrSmjn2kAnAewYVpGygSR0hLmRJAD3Fx9qh5-XbJnDsdEL071gt1dffiy-1jdfr6-2b27raxseK6UsrUclOY9alTGuV5x3qu-Eb20gxqUaamksLJ0dNOTddoJSU0thlq7rbxgr49zlxi-rZRyN_l0-DHOFNbUteVOplW8gPoI2hhSiuS6JfoJ430neHfwofvrQ_foQ_fHhyJ9edqx9hMN_wmPhy_AqxOAyeLoIs7Wp3-cqbWRSv4GMOKSSg</recordid><startdate>19990901</startdate><enddate>19990901</enddate><creator>YAMAGUCHI, K</creator><creator>OMAGARI, K</creator><creator>KINOSHITA, H</creator><creator>YOSHIOKA, S</creator><creator>FURUSU, H</creator><creator>TAKESHIMA, F</creator><creator>NANASHIMA, A</creator><creator>YAMAGUCHI, H</creator><creator>KOHNO, S</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>19990901</creationdate><title>Development of hepatocellular carcinoma in a patient with chronic hepatitis C after 6 years of a sustained and complete response to IFN-α</title><author>YAMAGUCHI, K ; OMAGARI, K ; KINOSHITA, H ; YOSHIOKA, S ; FURUSU, H ; TAKESHIMA, F ; NANASHIMA, A ; YAMAGUCHI, H ; KOHNO, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-55c23d580ba8a59ffb500b5b41b3cd5d597e5971c3fb584becf8f13e421d28f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Biological and medical sciences</topic><topic>Carcinoma, Hepatocellular - etiology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatitis C, Chronic - complications</topic><topic>Hepatitis C, Chronic - therapy</topic><topic>Humans</topic><topic>Interferon-alpha - therapeutic use</topic><topic>Liver Neoplasms - etiology</topic><topic>Liver. Biliary tract. Portal circulation. 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A 61-year-old Japanese man presented with a mass in the liver that was diagnosed as HCC. Six years earlier he was treated with IFN-alpha and responded successfully to therapy, with sustained normalization of serum aminotransferases and eradication of serum hepatitis C virus (HCV)-ribonucleic acid (RNA). HCV-RNA was also not detected in the resected tumorous and nontumorous liver tissues. The findings suggest that all patients with chronic HCV infection should be followed closely for as long as possible for the potential development of HCC even after a complete and sustained response to IFN treatment.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>10478890</pmid><doi>10.1097/00004836-199909000-00024</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0192-0790 |
| ispartof | Journal of clinical gastroenterology, 1999-09, Vol.29 (2), p.207-209 |
| issn | 0192-0790 1539-2031 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Biological and medical sciences Carcinoma, Hepatocellular - etiology Gastroenterology. Liver. Pancreas. Abdomen Hepatitis C, Chronic - complications Hepatitis C, Chronic - therapy Humans Interferon-alpha - therapeutic use Liver Neoplasms - etiology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Time Factors Tumors |
| title | Development of hepatocellular carcinoma in a patient with chronic hepatitis C after 6 years of a sustained and complete response to IFN-α |
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