Randomised, dose-ranging, placebo-controlled study of chimeric antibody to CD4 (keliximab) in chronic severe asthma

There is substantial circumstantial evidence that CD4 lymphocytes have a role in the pathogenesis of chronic asthma. We investigated the efficacy and safety in severe corticosteroid-dependent asthma of a single intravenous infusion of keliximab (IDEC CE9·1), a chimeric monoclonal antibody to CD4. 22...

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Veröffentlicht in:	The Lancet (British edition) 1998-10, Vol.352 (9134), p.1109-1113
Hauptverfasser:	Kon, Onn M, Sihra, Bhupinder S, Compton, Christopher H, Leonard, Thomas B, Kay, A Barry, Barnes, Neil C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal - therapeutic use Asthma Asthma - drug therapy Asthma - immunology Biological and medical sciences CD4 Antigens - immunology CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology Chronic Disease Dose-Response Relationship, Drug Drug therapy Female Humans Immune system Infusions, Intravenous Lymphocyte Count - drug effects Lymphocytes Male Medical research Medical sciences Middle Aged Pharmacology. Drug treatments Respiratory Function Tests Respiratory system Skin diseases
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