Schizophrenia and Complications of Pregnancy and Labor: An Individual Patient Data Meta-analysis
Several epidemiological studies have reported an association between complications of pregnancy and delivery and schizophrenia, but none have had sufficient power to examine specific complications that, individually, are of low prevalence. We, therefore, performed an individual patient meta-analysis...
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| Veröffentlicht in: | Schizophrenia bulletin 1999-01, Vol.25 (3), p.413-423 |
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| container_title | Schizophrenia bulletin |
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| creator | Geddes, John R. Verdoux, Hélène Takei, Nori Lawrie, Stephen M. Bovet, Pierre Eagles, John M. Heun, Reinhard McCreadie, Robin G. McNeil, Thomas F. O'Callaghan, Eadbhard Stöber, Gerald Willinger, Ulrike Murray, Robin M. |
| description | Several
epidemiological studies have reported an association between complications of
pregnancy and delivery and schizophrenia, but none have had sufficient power to
examine specific complications that, individually, are of low prevalence. We,
therefore, performed an individual patient meta-analysis using the raw data from
case control studies that used the Lewis-Murray scale. Data were obtained from
12 studies on 700 schizophrenia subjects and 835 controls. There were
significant associations between schizophrenia and premature rupture of
membranes, gestational age shorter than 37 weeks, and use of resuscitation or
incubator. There were associations of borderline significance between
schizophrenia and birthweight lower than 2,500 g and forceps delivery. There was
no significant interaction between these complications and sex. We conclude that
some abnormalities of pregnancy and delivery may be associated with development
of schizophrenia. The pathophysiology may involve hypoxia and so future studies
should focus on the accurate measurement of this exposure. |
| doi_str_mv | 10.1093/oxfordjournals.schbul.a033389 |
| format | Article |
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epidemiological studies have reported an association between complications of
pregnancy and delivery and schizophrenia, but none have had sufficient power to
examine specific complications that, individually, are of low prevalence. We,
therefore, performed an individual patient meta-analysis using the raw data from
case control studies that used the Lewis-Murray scale. Data were obtained from
12 studies on 700 schizophrenia subjects and 835 controls. There were
significant associations between schizophrenia and premature rupture of
membranes, gestational age shorter than 37 weeks, and use of resuscitation or
incubator. There were associations of borderline significance between
schizophrenia and birthweight lower than 2,500 g and forceps delivery. There was
no significant interaction between these complications and sex. We conclude that
some abnormalities of pregnancy and delivery may be associated with development
of schizophrenia. The pathophysiology may involve hypoxia and so future studies
should focus on the accurate measurement of this exposure.</description><identifier>ISSN: 0586-7614</identifier><identifier>EISSN: 1745-1701</identifier><identifier>DOI: 10.1093/oxfordjournals.schbul.a033389</identifier><identifier>PMID: 10478777</identifier><identifier>CODEN: SCZBB3</identifier><language>eng</language><publisher>Oxford: National Institute of Mental Health</publisher><subject>Adult and adolescent clinical studies ; Biological and medical sciences ; Birth ; Case-Control Studies ; Extraction, Obstetrical - adverse effects ; Extraction, Obstetrical - statistics & numerical data ; Female ; Human ; Humans ; Labor (Childbirth) ; Male ; Medical sciences ; Obstetric Labor, Premature - complications ; Obstetric Labor, Premature - epidemiology ; Obstetrical Complications ; Pregnancy ; Pregnancy Complications - epidemiology ; Prenatal Development ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Research Design ; Schizophrenia ; Schizophrenia - epidemiology ; Schizophrenia - etiology ; Sequelae ; Statistics as Topic ; Systematic review</subject><ispartof>Schizophrenia bulletin, 1999-01, Vol.25 (3), p.413-423</ispartof><rights>1999 INIST-CNRS</rights><rights>Copyright Superintendent of Documents 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a561t-1d54da575a4319df6c1c2071b6a125fbc3caf2707e099c5fe9fb4bd4a7407ec73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1940150$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10478777$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Geddes, John R.</creatorcontrib><creatorcontrib>Verdoux, Hélène</creatorcontrib><creatorcontrib>Takei, Nori</creatorcontrib><creatorcontrib>Lawrie, Stephen M.</creatorcontrib><creatorcontrib>Bovet, Pierre</creatorcontrib><creatorcontrib>Eagles, John M.</creatorcontrib><creatorcontrib>Heun, Reinhard</creatorcontrib><creatorcontrib>McCreadie, Robin G.</creatorcontrib><creatorcontrib>McNeil, Thomas F.</creatorcontrib><creatorcontrib>O'Callaghan, Eadbhard</creatorcontrib><creatorcontrib>Stöber, Gerald</creatorcontrib><creatorcontrib>Willinger, Ulrike</creatorcontrib><creatorcontrib>Murray, Robin M.</creatorcontrib><title>Schizophrenia and Complications of Pregnancy and Labor: An Individual Patient Data Meta-analysis</title><title>Schizophrenia bulletin</title><addtitle>Schizophr Bull</addtitle><description>Several
epidemiological studies have reported an association between complications of
pregnancy and delivery and schizophrenia, but none have had sufficient power to
examine specific complications that, individually, are of low prevalence. We,
therefore, performed an individual patient meta-analysis using the raw data from
case control studies that used the Lewis-Murray scale. Data were obtained from
12 studies on 700 schizophrenia subjects and 835 controls. There were
significant associations between schizophrenia and premature rupture of
membranes, gestational age shorter than 37 weeks, and use of resuscitation or
incubator. There were associations of borderline significance between
schizophrenia and birthweight lower than 2,500 g and forceps delivery. There was
no significant interaction between these complications and sex. We conclude that
some abnormalities of pregnancy and delivery may be associated with development
of schizophrenia. The pathophysiology may involve hypoxia and so future studies
should focus on the accurate measurement of this exposure.</description><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Birth</subject><subject>Case-Control Studies</subject><subject>Extraction, Obstetrical - adverse effects</subject><subject>Extraction, Obstetrical - statistics & numerical data</subject><subject>Female</subject><subject>Human</subject><subject>Humans</subject><subject>Labor (Childbirth)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Obstetric Labor, Premature - complications</subject><subject>Obstetric Labor, Premature - epidemiology</subject><subject>Obstetrical Complications</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - epidemiology</subject><subject>Prenatal Development</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Research Design</subject><subject>Schizophrenia</subject><subject>Schizophrenia - epidemiology</subject><subject>Schizophrenia - etiology</subject><subject>Sequelae</subject><subject>Statistics as Topic</subject><subject>Systematic review</subject><issn>0586-7614</issn><issn>1745-1701</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhi1ERZfCX0ARAi4oiz_jdSUO1UJLpUVUAs5m4tisq6wd7ASx_fW4zSI-Dpws2c943pkHoecELwlW7FX84WLqruOUAvR5mc22nfolYMbYSt1DCyK5qInE5D5aYLFqatkQfowe5nyNMeGqoQ_QMcFcrqSUC_Tlo9n6mzhskw0eKghdtY67ofcGRh9DrqKrrpL9GiCY_d3zBtqYTquzUF2Gzn_33QR9dVVoG8bqDYxQvbcj1FDi7bPPj9CRK0Ht48N5gj6fv_20fldvPlxcrs82NYiGjDXpBO9ASAGcEdW5xhBDsSRtA4QK1xpmwFGJpcVKGeGsci1vOw6Slzsj2Ql6Mf87pPhtsnnUO5-N7XsINk5ZyzK9EooX8Ok_4K9l6rIpxign6n8QpawkpuK25esZMinmnKzTQ_I7SHtNsL6Vpf-WpWdZ-iCr1D85NJnane3-qJ7tFODZAYBsoHepSPD5N6c4JgIX7OWMwQB6yHsDafSmt9lMqWgddb5pNRWaaU4Y-wkzvLRr</recordid><startdate>19990101</startdate><enddate>19990101</enddate><creator>Geddes, John R.</creator><creator>Verdoux, Hélène</creator><creator>Takei, Nori</creator><creator>Lawrie, Stephen M.</creator><creator>Bovet, Pierre</creator><creator>Eagles, John M.</creator><creator>Heun, Reinhard</creator><creator>McCreadie, Robin G.</creator><creator>McNeil, Thomas F.</creator><creator>O'Callaghan, Eadbhard</creator><creator>Stöber, Gerald</creator><creator>Willinger, Ulrike</creator><creator>Murray, Robin M.</creator><general>National Institute of Mental Health</general><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7X8</scope></search><sort><creationdate>19990101</creationdate><title>Schizophrenia and Complications of Pregnancy and Labor: An Individual Patient Data Meta-analysis</title><author>Geddes, John R. ; Verdoux, Hélène ; Takei, Nori ; Lawrie, Stephen M. ; Bovet, Pierre ; Eagles, John M. ; Heun, Reinhard ; McCreadie, Robin G. ; McNeil, Thomas F. ; O'Callaghan, Eadbhard ; Stöber, Gerald ; Willinger, Ulrike ; Murray, Robin M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a561t-1d54da575a4319df6c1c2071b6a125fbc3caf2707e099c5fe9fb4bd4a7407ec73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>Birth</topic><topic>Case-Control Studies</topic><topic>Extraction, Obstetrical - adverse effects</topic><topic>Extraction, Obstetrical - statistics & numerical data</topic><topic>Female</topic><topic>Human</topic><topic>Humans</topic><topic>Labor (Childbirth)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Obstetric Labor, Premature - complications</topic><topic>Obstetric Labor, Premature - epidemiology</topic><topic>Obstetrical Complications</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - epidemiology</topic><topic>Prenatal Development</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Research Design</topic><topic>Schizophrenia</topic><topic>Schizophrenia - epidemiology</topic><topic>Schizophrenia - etiology</topic><topic>Sequelae</topic><topic>Statistics as Topic</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Geddes, John R.</creatorcontrib><creatorcontrib>Verdoux, Hélène</creatorcontrib><creatorcontrib>Takei, Nori</creatorcontrib><creatorcontrib>Lawrie, Stephen M.</creatorcontrib><creatorcontrib>Bovet, Pierre</creatorcontrib><creatorcontrib>Eagles, John M.</creatorcontrib><creatorcontrib>Heun, Reinhard</creatorcontrib><creatorcontrib>McCreadie, Robin G.</creatorcontrib><creatorcontrib>McNeil, Thomas F.</creatorcontrib><creatorcontrib>O'Callaghan, Eadbhard</creatorcontrib><creatorcontrib>Stöber, Gerald</creatorcontrib><creatorcontrib>Willinger, Ulrike</creatorcontrib><creatorcontrib>Murray, Robin M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>APA PsycArticles®</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><jtitle>Schizophrenia bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Geddes, John R.</au><au>Verdoux, Hélène</au><au>Takei, Nori</au><au>Lawrie, Stephen M.</au><au>Bovet, Pierre</au><au>Eagles, John M.</au><au>Heun, Reinhard</au><au>McCreadie, Robin G.</au><au>McNeil, Thomas F.</au><au>O'Callaghan, Eadbhard</au><au>Stöber, Gerald</au><au>Willinger, Ulrike</au><au>Murray, Robin M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Schizophrenia and Complications of Pregnancy and Labor: An Individual Patient Data Meta-analysis</atitle><jtitle>Schizophrenia bulletin</jtitle><addtitle>Schizophr Bull</addtitle><date>1999-01-01</date><risdate>1999</risdate><volume>25</volume><issue>3</issue><spage>413</spage><epage>423</epage><pages>413-423</pages><issn>0586-7614</issn><eissn>1745-1701</eissn><coden>SCZBB3</coden><abstract>Several
epidemiological studies have reported an association between complications of
pregnancy and delivery and schizophrenia, but none have had sufficient power to
examine specific complications that, individually, are of low prevalence. We,
therefore, performed an individual patient meta-analysis using the raw data from
case control studies that used the Lewis-Murray scale. Data were obtained from
12 studies on 700 schizophrenia subjects and 835 controls. There were
significant associations between schizophrenia and premature rupture of
membranes, gestational age shorter than 37 weeks, and use of resuscitation or
incubator. There were associations of borderline significance between
schizophrenia and birthweight lower than 2,500 g and forceps delivery. There was
no significant interaction between these complications and sex. We conclude that
some abnormalities of pregnancy and delivery may be associated with development
of schizophrenia. The pathophysiology may involve hypoxia and so future studies
should focus on the accurate measurement of this exposure.</abstract><cop>Oxford</cop><pub>National Institute of Mental Health</pub><pmid>10478777</pmid><doi>10.1093/oxfordjournals.schbul.a033389</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Schizophrenia bulletin, 1999-01, Vol.25 (3), p.413-423 |
| issn | 0586-7614 1745-1701 |
| language | eng |
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| source | APA PsycARTICLES; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult and adolescent clinical studies Biological and medical sciences Birth Case-Control Studies Extraction, Obstetrical - adverse effects Extraction, Obstetrical - statistics & numerical data Female Human Humans Labor (Childbirth) Male Medical sciences Obstetric Labor, Premature - complications Obstetric Labor, Premature - epidemiology Obstetrical Complications Pregnancy Pregnancy Complications - epidemiology Prenatal Development Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Research Design Schizophrenia Schizophrenia - epidemiology Schizophrenia - etiology Sequelae Statistics as Topic Systematic review |
| title | Schizophrenia and Complications of Pregnancy and Labor: An Individual Patient Data Meta-analysis |
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