Longitudinal study of Plasmodium falciparum infection and immune responses in infants with or without the sickle cell trait
Individuals may be homozygous (SS) or heterozygous (AS) sickle cell gene carriers or have normal adult haemoglobin (AA). Haemoglobin S could have a protective role against malaria but evidence is sparse and the operating mechanisms are poorly known. We followed two cohorts of children. The first was...
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| Veröffentlicht in: | International journal of epidemiology 1999-08, Vol.28 (4), p.793-798 |
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| creator | LE HESRAN, J. Y PERSONNE, I PERSONNE, P FIEVET, N DUBOIS, B BEYEME, M BOUDIN, C COT, M DELORON, P |
| description | Individuals may be homozygous (SS) or heterozygous (AS) sickle cell gene carriers or have normal adult haemoglobin (AA). Haemoglobin S could have a protective role against malaria but evidence is sparse and the operating mechanisms are poorly known.
We followed two cohorts of children. The first was enrolled at birth (156 newborn babies) and the second at 24-36 months old (84 children). Both cohorts were followed for 30 months; monthly for parasitological data and half yearly for immunological data.
In the first cohort, 22%, and in the second 13% of children were AS. Whatever their age parasite prevalence rates were similar in AA and AS individuals. Mean parasite densities increased less rapidly with age in AS than in AA children, and were significantly lower in AS than in AA children >48 months old. The AA children tended to be more often admitted to hospital than AS children (22% versus 11%, NS). Both anti-Plasmodium falciparum and anti-Pfl55/RESA antibody rates increased more rapidly in AA than in AS children. Conversely, the prevalence rate of cellular responders to the Pfl55/RESA antigen was similar in AA and AS children during the first 2 years of life, then it was higher in AS than in AA children.
Sickle cell trait related antimalarial protection varies with age. The role of the modifications of the specific immune response to P. falciparum in explaining the protection of AS children against malaria is discussed. |
| doi_str_mv | 10.1093/ije/28.4.793 |
| format | Article |
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We followed two cohorts of children. The first was enrolled at birth (156 newborn babies) and the second at 24-36 months old (84 children). Both cohorts were followed for 30 months; monthly for parasitological data and half yearly for immunological data.
In the first cohort, 22%, and in the second 13% of children were AS. Whatever their age parasite prevalence rates were similar in AA and AS individuals. Mean parasite densities increased less rapidly with age in AS than in AA children, and were significantly lower in AS than in AA children >48 months old. The AA children tended to be more often admitted to hospital than AS children (22% versus 11%, NS). Both anti-Plasmodium falciparum and anti-Pfl55/RESA antibody rates increased more rapidly in AA than in AS children. Conversely, the prevalence rate of cellular responders to the Pfl55/RESA antigen was similar in AA and AS children during the first 2 years of life, then it was higher in AS than in AA children.
Sickle cell trait related antimalarial protection varies with age. The role of the modifications of the specific immune response to P. falciparum in explaining the protection of AS children against malaria is discussed.</description><identifier>ISSN: 0300-5771</identifier><identifier>EISSN: 1464-3685</identifier><identifier>DOI: 10.1093/ije/28.4.793</identifier><identifier>PMID: 10480713</identifier><identifier>CODEN: IJEPBF</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Animals ; Antibodies, Protozoan - analysis ; Biological and medical sciences ; Cameroon - epidemiology ; Child, Preschool ; Erythrocytes - immunology ; Erythrocytes - metabolism ; Erythrocytes - parasitology ; Female ; Follow-Up Studies ; Genotype ; Hemoglobin A - genetics ; Hemoglobin, Sickle - genetics ; Human protozoal diseases ; Humans ; Immunity, Cellular ; Infant ; Infant, Newborn ; Infectious diseases ; Malaria ; Malaria, Falciparum - complications ; Malaria, Falciparum - epidemiology ; Malaria, Falciparum - immunology ; Malaria, Falciparum - parasitology ; Male ; Medical sciences ; Parasitic diseases ; Plasmodium falciparum - immunology ; Plasmodium falciparum - isolation & purification ; Prevalence ; Protozoal diseases ; Protozoan Proteins - immunology ; Retrospective Studies ; Sickle Cell Trait - blood ; Sickle Cell Trait - complications ; Sickle Cell Trait - immunology ; Tropical medicine</subject><ispartof>International journal of epidemiology, 1999-08, Vol.28 (4), p.793-798</ispartof><rights>1999 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Aug 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-ac4a22908cd70fc48c41b4304385d97d60894c85f87f9cb272f5f19fddabffb33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1904861$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10480713$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LE HESRAN, J. Y</creatorcontrib><creatorcontrib>PERSONNE, I</creatorcontrib><creatorcontrib>PERSONNE, P</creatorcontrib><creatorcontrib>FIEVET, N</creatorcontrib><creatorcontrib>DUBOIS, B</creatorcontrib><creatorcontrib>BEYEME, M</creatorcontrib><creatorcontrib>BOUDIN, C</creatorcontrib><creatorcontrib>COT, M</creatorcontrib><creatorcontrib>DELORON, P</creatorcontrib><title>Longitudinal study of Plasmodium falciparum infection and immune responses in infants with or without the sickle cell trait</title><title>International journal of epidemiology</title><addtitle>Int J Epidemiol</addtitle><description>Individuals may be homozygous (SS) or heterozygous (AS) sickle cell gene carriers or have normal adult haemoglobin (AA). Haemoglobin S could have a protective role against malaria but evidence is sparse and the operating mechanisms are poorly known.
We followed two cohorts of children. The first was enrolled at birth (156 newborn babies) and the second at 24-36 months old (84 children). Both cohorts were followed for 30 months; monthly for parasitological data and half yearly for immunological data.
In the first cohort, 22%, and in the second 13% of children were AS. Whatever their age parasite prevalence rates were similar in AA and AS individuals. Mean parasite densities increased less rapidly with age in AS than in AA children, and were significantly lower in AS than in AA children >48 months old. The AA children tended to be more often admitted to hospital than AS children (22% versus 11%, NS). Both anti-Plasmodium falciparum and anti-Pfl55/RESA antibody rates increased more rapidly in AA than in AS children. Conversely, the prevalence rate of cellular responders to the Pfl55/RESA antigen was similar in AA and AS children during the first 2 years of life, then it was higher in AS than in AA children.
Sickle cell trait related antimalarial protection varies with age. The role of the modifications of the specific immune response to P. falciparum in explaining the protection of AS children against malaria is discussed.</description><subject>Animals</subject><subject>Antibodies, Protozoan - analysis</subject><subject>Biological and medical sciences</subject><subject>Cameroon - epidemiology</subject><subject>Child, Preschool</subject><subject>Erythrocytes - immunology</subject><subject>Erythrocytes - metabolism</subject><subject>Erythrocytes - parasitology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Genotype</subject><subject>Hemoglobin A - genetics</subject><subject>Hemoglobin, Sickle - genetics</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Immunity, Cellular</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infectious diseases</subject><subject>Malaria</subject><subject>Malaria, Falciparum - complications</subject><subject>Malaria, Falciparum - epidemiology</subject><subject>Malaria, Falciparum - immunology</subject><subject>Malaria, Falciparum - parasitology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Parasitic diseases</subject><subject>Plasmodium falciparum - immunology</subject><subject>Plasmodium falciparum - isolation & purification</subject><subject>Prevalence</subject><subject>Protozoal diseases</subject><subject>Protozoan Proteins - immunology</subject><subject>Retrospective Studies</subject><subject>Sickle Cell Trait - blood</subject><subject>Sickle Cell Trait - complications</subject><subject>Sickle Cell Trait - immunology</subject><subject>Tropical medicine</subject><issn>0300-5771</issn><issn>1464-3685</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0c1rFDEYBvAgFrut3jxLEOnJ2SaTzCY5luIXLNhDPYdMPmzWmWTNm0FK_3mz7oLi6X0hPx7C-yD0mpI1JYpdx52_7uWar4Viz9CK8g3v2EYOz9GKMEK6QQh6ji4AdoRQzrl6gc4p4ZIIylboaZvT91gXF5OZMLTlEeeA7yYDc3ZxmXEwk417U9oaU_C2xpywSQ7HeV6Sx8XDPifw0J4PwqQK-FesDziXPzMvFdcHjyHaH5PH1k8TrsXE-hKdtXDwr07zEn37-OH-9nO3_frpy-3NtrNM0toZy03fKyKtEyRYLi2nI2eEMzk4JdyGSMWtHIIUQdmxF30YAlXBOTOGMDJ2ia6OufuSfy4eqp4jHL5hks8LaNEOo4ahb_Dtf3CXl9IOA7qninLCqWjo_RHZkgGKD3pf4mzKo6ZEHxrRrRHdS811a6TxN6fMZZy9-wcfK2jg3QkYsGYKxSQb4a9TDW4o-w1n_JXT</recordid><startdate>19990801</startdate><enddate>19990801</enddate><creator>LE HESRAN, J. 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Y ; PERSONNE, I ; PERSONNE, P ; FIEVET, N ; DUBOIS, B ; BEYEME, M ; BOUDIN, C ; COT, M ; DELORON, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-ac4a22908cd70fc48c41b4304385d97d60894c85f87f9cb272f5f19fddabffb33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Antibodies, Protozoan - analysis</topic><topic>Biological and medical sciences</topic><topic>Cameroon - epidemiology</topic><topic>Child, Preschool</topic><topic>Erythrocytes - immunology</topic><topic>Erythrocytes - metabolism</topic><topic>Erythrocytes - parasitology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Genotype</topic><topic>Hemoglobin A - genetics</topic><topic>Hemoglobin, Sickle - genetics</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Immunity, Cellular</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infectious diseases</topic><topic>Malaria</topic><topic>Malaria, Falciparum - complications</topic><topic>Malaria, Falciparum - epidemiology</topic><topic>Malaria, Falciparum - immunology</topic><topic>Malaria, Falciparum - parasitology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Parasitic diseases</topic><topic>Plasmodium falciparum - immunology</topic><topic>Plasmodium falciparum - isolation & purification</topic><topic>Prevalence</topic><topic>Protozoal diseases</topic><topic>Protozoan Proteins - immunology</topic><topic>Retrospective Studies</topic><topic>Sickle Cell Trait - blood</topic><topic>Sickle Cell Trait - complications</topic><topic>Sickle Cell Trait - immunology</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LE HESRAN, J. Y</creatorcontrib><creatorcontrib>PERSONNE, I</creatorcontrib><creatorcontrib>PERSONNE, P</creatorcontrib><creatorcontrib>FIEVET, N</creatorcontrib><creatorcontrib>DUBOIS, B</creatorcontrib><creatorcontrib>BEYEME, M</creatorcontrib><creatorcontrib>BOUDIN, C</creatorcontrib><creatorcontrib>COT, M</creatorcontrib><creatorcontrib>DELORON, P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LE HESRAN, J. Y</au><au>PERSONNE, I</au><au>PERSONNE, P</au><au>FIEVET, N</au><au>DUBOIS, B</au><au>BEYEME, M</au><au>BOUDIN, C</au><au>COT, M</au><au>DELORON, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal study of Plasmodium falciparum infection and immune responses in infants with or without the sickle cell trait</atitle><jtitle>International journal of epidemiology</jtitle><addtitle>Int J Epidemiol</addtitle><date>1999-08-01</date><risdate>1999</risdate><volume>28</volume><issue>4</issue><spage>793</spage><epage>798</epage><pages>793-798</pages><issn>0300-5771</issn><eissn>1464-3685</eissn><coden>IJEPBF</coden><abstract>Individuals may be homozygous (SS) or heterozygous (AS) sickle cell gene carriers or have normal adult haemoglobin (AA). Haemoglobin S could have a protective role against malaria but evidence is sparse and the operating mechanisms are poorly known.
We followed two cohorts of children. The first was enrolled at birth (156 newborn babies) and the second at 24-36 months old (84 children). Both cohorts were followed for 30 months; monthly for parasitological data and half yearly for immunological data.
In the first cohort, 22%, and in the second 13% of children were AS. Whatever their age parasite prevalence rates were similar in AA and AS individuals. Mean parasite densities increased less rapidly with age in AS than in AA children, and were significantly lower in AS than in AA children >48 months old. The AA children tended to be more often admitted to hospital than AS children (22% versus 11%, NS). Both anti-Plasmodium falciparum and anti-Pfl55/RESA antibody rates increased more rapidly in AA than in AS children. Conversely, the prevalence rate of cellular responders to the Pfl55/RESA antigen was similar in AA and AS children during the first 2 years of life, then it was higher in AS than in AA children.
Sickle cell trait related antimalarial protection varies with age. The role of the modifications of the specific immune response to P. falciparum in explaining the protection of AS children against malaria is discussed.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>10480713</pmid><doi>10.1093/ije/28.4.793</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0300-5771 |
| ispartof | International journal of epidemiology, 1999-08, Vol.28 (4), p.793-798 |
| issn | 0300-5771 1464-3685 |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Antibodies, Protozoan - analysis Biological and medical sciences Cameroon - epidemiology Child, Preschool Erythrocytes - immunology Erythrocytes - metabolism Erythrocytes - parasitology Female Follow-Up Studies Genotype Hemoglobin A - genetics Hemoglobin, Sickle - genetics Human protozoal diseases Humans Immunity, Cellular Infant Infant, Newborn Infectious diseases Malaria Malaria, Falciparum - complications Malaria, Falciparum - epidemiology Malaria, Falciparum - immunology Malaria, Falciparum - parasitology Male Medical sciences Parasitic diseases Plasmodium falciparum - immunology Plasmodium falciparum - isolation & purification Prevalence Protozoal diseases Protozoan Proteins - immunology Retrospective Studies Sickle Cell Trait - blood Sickle Cell Trait - complications Sickle Cell Trait - immunology Tropical medicine |
| title | Longitudinal study of Plasmodium falciparum infection and immune responses in infants with or without the sickle cell trait |
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