Insulin Improves Cardiac Contractile Function and Oxygen Utilization Efficiency During Moderate Ischemia Without Compromising Myocardial Energetics

Insulin improves myocardial contractile function during moderate ischemia, but the mechanism is unknown. To determine effects of insulin on myocardial oxygen utilization efficiency (O2UE) and energetics, regional left coronary perfusion pressure (CPP) was lowered sequentially from 100 to 60, 50, and...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 1998-10, Vol.30 (10), p.2025-2035
Hauptverfasser:	Tune, Johnathan D., Mallet, Robert T., Downey, H.Fred
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Blood Glucose - metabolism Contractile function Coronary Circulation - drug effects Coronary Circulation - physiology Coronary Vessels - drug effects Coronary Vessels - physiology Coronary Vessels - physiopathology Creatine - metabolism Dogs Energy Metabolism - drug effects Female Heart - drug effects Heart - physiology Heart - physiopathology Insulin Insulin - pharmacology Male Myocardial Contraction - drug effects Myocardial Contraction - physiology Myocardial energetics Myocardial Ischemia - metabolism Myocardial Ischemia - physiopathology Myocardium - metabolism Oxygen Consumption - drug effects Oxygen utilization efficiency Phosphocreatine - metabolism Reference Values
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