Induction of Cyclooxygenase-2 by Secretory Phospholipases A2 in Nerve Growth Factor-Stimulated Rat Serosal Mast Cells Is Facilitated by Interaction with Fibroblasts and Mediated by a Mechanism Independent of Their Enzymatic Functions

Mast cells exhibit a biphasic (immediate and delayed) eicosanoid-biosynthetic response after stimulation with particular cytokines or Fc epsilonRI (high affinity receptor for IgE) cross-linking. Treatment of rat serosal connective tissue mast cells (CTMC) with nerve growth factor (NGF) induced only...

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Veröffentlicht in:	The Journal of immunology (1950) 1998-11, Vol.161 (9), p.5008-5015
Hauptverfasser:	Tada, Kinji, Murakami, Makoto, Kambe, Terumi, Kudo, Ichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic Acid - metabolism Cell Communication Cells, Cultured Connective Tissue Cells - drug effects Connective Tissue Cells - enzymology Cyclooxygenase 1 Enzyme Induction - drug effects Enzyme Inhibitors - pharmacology Fibroblasts - physiology Group II Phospholipases A2 Humans Isoenzymes - biosynthesis Isoenzymes - genetics Isoenzymes - pharmacology Mast Cells - drug effects Mast Cells - enzymology Membrane Lipids - metabolism Membrane Proteins Mice Nerve Growth Factors - pharmacology Phospholipases A - pharmacology Phospholipases A2 Prostaglandin D2 - biosynthesis Prostaglandin D2 - genetics Prostaglandin-Endoperoxide Synthases - biosynthesis Prostaglandin-Endoperoxide Synthases - genetics Rats Rats, Wistar
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