A novel gain-of-function mutation of c- kit gene in gastrointestinal stromal tumors

Background & Aims: The c- kit gene encodes a receptor tyrosine kinase (KIT). Recently, we found gain-of-function mutations of the c- kit gene in gastrointestinal stromal tumors (GISTs). All mutations were confined within the 11 amino acids (Lys-550 to Val-560) in the juxtamembrane domain, but on...

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