Development and evaluation of a new alcohol-based surgical hand scrub formulation with persistent antimicrobial characteristics and brushless application
Background: Since the introduction in the 1970s of surgical hand scrub formulations that contain 4% chlorhexidine gluconate (CHG), new surgical scrub formulations that have improved efficacy, persistence, or significantly improved use characteristics have not been forthcoming. In addition, the manuf...
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| Veröffentlicht in: | American journal of infection control 1998-10, Vol.26 (5), p.507-512 |
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| creator | Hobson, D.W. Woller, W. Anderson, L. Guthery, E. |
| description | Background: Since the introduction in the 1970s of surgical hand scrub formulations that contain 4% chlorhexidine gluconate (CHG), new surgical scrub formulations that have improved efficacy, persistence, or significantly improved use characteristics have not been forthcoming. In addition, the manufacturer’s labeling for popular hand scrub products generally requires scrub times in excess of 6 minutes, whereas current practical needs call for products with substantially shorter scrub times. A new alcohol-based surgical scrub formulation, which has ingredients that provide emollient, surfactant, and antimicrobial persistence characteristics to complement the rapid and broad-spectrum antiseptic qualities of alcohol, has been developed in an effort to address these current practical needs.
Methods: The relative efficacy of a new alcohol-based surgical scrub formulation that contains ingredients that provide surfactant and antimicrobial persistence characteristics was compared with that of commercial 4% CHG and 7.5% povidone iodine (PVPI) formulations with use of human subjects. Hand antimicrobial count sampling was performed by using standardized “glove juice” methodology.
Results: The efficacy and persistence results of the new formulation showed statistically significant improvement over both CHG and PVPI at a substantially lessened scrub time (3 minutes). In addition, use of the new formulation without a scrub brush produced results statistically similar to 3-minute applications with either a brush or a sponge.
Conclusions: The new alcohol-based formulation demonstrates promise as a new surgical hand scrub formulation with antimicrobial and use characteristics that are significantly improved over current CHG and PVPI formulations. These studies demonstrate the suitability of this formulation for use as a surgical hand scrub and for brushless application. (AJIC Am J Infect Control 1998;26:507-12) |
| doi_str_mv | 10.1016/S0196-6553(98)70024-0 |
| format | Article |
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Methods: The relative efficacy of a new alcohol-based surgical scrub formulation that contains ingredients that provide surfactant and antimicrobial persistence characteristics was compared with that of commercial 4% CHG and 7.5% povidone iodine (PVPI) formulations with use of human subjects. Hand antimicrobial count sampling was performed by using standardized “glove juice” methodology.
Results: The efficacy and persistence results of the new formulation showed statistically significant improvement over both CHG and PVPI at a substantially lessened scrub time (3 minutes). In addition, use of the new formulation without a scrub brush produced results statistically similar to 3-minute applications with either a brush or a sponge.
Conclusions: The new alcohol-based formulation demonstrates promise as a new surgical hand scrub formulation with antimicrobial and use characteristics that are significantly improved over current CHG and PVPI formulations. These studies demonstrate the suitability of this formulation for use as a surgical hand scrub and for brushless application. (AJIC Am J Infect Control 1998;26:507-12)</description><identifier>ISSN: 0196-6553</identifier><identifier>EISSN: 1527-3296</identifier><identifier>DOI: 10.1016/S0196-6553(98)70024-0</identifier><identifier>PMID: 9795680</identifier><language>eng</language><publisher>St. Louis, MO: Mosby, Inc</publisher><subject>Administration, Topical ; Alcohols - administration & dosage ; Alcohols - pharmacology ; Anti-Infective Agents - administration & dosage ; Anti-Infective Agents - pharmacology ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiseptics ; Biological and medical sciences ; Chlorhexidine - administration & dosage ; Chlorhexidine - analogs & derivatives ; Chlorhexidine - pharmacology ; Consumer Product Safety ; Dermatologic Agents - pharmacology ; Hand Disinfection - methods ; Hand Disinfection - standards ; Humans ; Medical sciences ; Miscellaneous ; Operating Rooms ; Pharmacology. Drug treatments ; Practice Guidelines as Topic ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; United States ; United States Food and Drug Administration</subject><ispartof>American journal of infection control, 1998-10, Vol.26 (5), p.507-512</ispartof><rights>1998 Association for Professionals in Infection Control and Epidemiology, Inc</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-7dce101fceb265e7aa9a19d7bf5a9fb9bb43b726ca994661a3288d97e1010d913</citedby><cites>FETCH-LOGICAL-c389t-7dce101fceb265e7aa9a19d7bf5a9fb9bb43b726ca994661a3288d97e1010d913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0196-6553(98)70024-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2421561$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9795680$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hobson, D.W.</creatorcontrib><creatorcontrib>Woller, W.</creatorcontrib><creatorcontrib>Anderson, L.</creatorcontrib><creatorcontrib>Guthery, E.</creatorcontrib><title>Development and evaluation of a new alcohol-based surgical hand scrub formulation with persistent antimicrobial characteristics and brushless application</title><title>American journal of infection control</title><addtitle>Am J Infect Control</addtitle><description>Background: Since the introduction in the 1970s of surgical hand scrub formulations that contain 4% chlorhexidine gluconate (CHG), new surgical scrub formulations that have improved efficacy, persistence, or significantly improved use characteristics have not been forthcoming. In addition, the manufacturer’s labeling for popular hand scrub products generally requires scrub times in excess of 6 minutes, whereas current practical needs call for products with substantially shorter scrub times. A new alcohol-based surgical scrub formulation, which has ingredients that provide emollient, surfactant, and antimicrobial persistence characteristics to complement the rapid and broad-spectrum antiseptic qualities of alcohol, has been developed in an effort to address these current practical needs.
Methods: The relative efficacy of a new alcohol-based surgical scrub formulation that contains ingredients that provide surfactant and antimicrobial persistence characteristics was compared with that of commercial 4% CHG and 7.5% povidone iodine (PVPI) formulations with use of human subjects. Hand antimicrobial count sampling was performed by using standardized “glove juice” methodology.
Results: The efficacy and persistence results of the new formulation showed statistically significant improvement over both CHG and PVPI at a substantially lessened scrub time (3 minutes). In addition, use of the new formulation without a scrub brush produced results statistically similar to 3-minute applications with either a brush or a sponge.
Conclusions: The new alcohol-based formulation demonstrates promise as a new surgical hand scrub formulation with antimicrobial and use characteristics that are significantly improved over current CHG and PVPI formulations. These studies demonstrate the suitability of this formulation for use as a surgical hand scrub and for brushless application. (AJIC Am J Infect Control 1998;26:507-12)</description><subject>Administration, Topical</subject><subject>Alcohols - administration & dosage</subject><subject>Alcohols - pharmacology</subject><subject>Anti-Infective Agents - administration & dosage</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiseptics</subject><subject>Biological and medical sciences</subject><subject>Chlorhexidine - administration & dosage</subject><subject>Chlorhexidine - analogs & derivatives</subject><subject>Chlorhexidine - pharmacology</subject><subject>Consumer Product Safety</subject><subject>Dermatologic Agents - pharmacology</subject><subject>Hand Disinfection - methods</subject><subject>Hand Disinfection - standards</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Operating Rooms</subject><subject>Pharmacology. Drug treatments</subject><subject>Practice Guidelines as Topic</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>United States</subject><subject>United States Food and Drug Administration</subject><issn>0196-6553</issn><issn>1527-3296</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUc2q1DAYDaJcx6uPcCELEV1Uk3aaNiuR6y9ccKGuw5f0qxNJm5qvnYuP4tuaTofZugrh_CXnMHYjxWsppHrzTUitClXX1UvdvmqEKPeFeMB2si6boiq1esh2F8pj9oTolxBCV6q-Yle60bVqxY79fY9HDHEacJw5jB3HI4QFZh9HHnsOfMR7DsHFQwyFBcKO05J-egeBH1Y-ubRY3sc0LGGT3fv5wCdM5GneXGc_eJei9VnkDpDAzZgy6h2dMm1a6BCQ8m2aQvZefZ6yRz0Ewmfn85r9-Pjh--3n4u7rpy-37-4KV7V6LprOYe6jd2hLVWMDoEHqrrF9Dbq32tp9ZZtSOdB6r5SEqmzbTjerSHRaVtfsxeY7pfh7QZrN4MlhCDBiXMjkZmUjT8R6I-avECXszZT8AOmPkcKsk5jTJGbt2-jWnCYxIutuzgGLHbC7qM4bZPz5GQfKtfYJRufpQiv3pazVGv92o2Eu4-gxGXIeR4edT-hm00X_n4f8A8C7rQg</recordid><startdate>19981001</startdate><enddate>19981001</enddate><creator>Hobson, D.W.</creator><creator>Woller, W.</creator><creator>Anderson, L.</creator><creator>Guthery, E.</creator><general>Mosby, Inc</general><general>Mosby</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19981001</creationdate><title>Development and evaluation of a new alcohol-based surgical hand scrub formulation with persistent antimicrobial characteristics and brushless application</title><author>Hobson, D.W. ; Woller, W. ; Anderson, L. ; Guthery, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-7dce101fceb265e7aa9a19d7bf5a9fb9bb43b726ca994661a3288d97e1010d913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Administration, Topical</topic><topic>Alcohols - administration & dosage</topic><topic>Alcohols - pharmacology</topic><topic>Anti-Infective Agents - administration & dosage</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiseptics</topic><topic>Biological and medical sciences</topic><topic>Chlorhexidine - administration & dosage</topic><topic>Chlorhexidine - analogs & derivatives</topic><topic>Chlorhexidine - pharmacology</topic><topic>Consumer Product Safety</topic><topic>Dermatologic Agents - pharmacology</topic><topic>Hand Disinfection - methods</topic><topic>Hand Disinfection - standards</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Operating Rooms</topic><topic>Pharmacology. Drug treatments</topic><topic>Practice Guidelines as Topic</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>United States</topic><topic>United States Food and Drug Administration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hobson, D.W.</creatorcontrib><creatorcontrib>Woller, W.</creatorcontrib><creatorcontrib>Anderson, L.</creatorcontrib><creatorcontrib>Guthery, E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of infection control</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hobson, D.W.</au><au>Woller, W.</au><au>Anderson, L.</au><au>Guthery, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development and evaluation of a new alcohol-based surgical hand scrub formulation with persistent antimicrobial characteristics and brushless application</atitle><jtitle>American journal of infection control</jtitle><addtitle>Am J Infect Control</addtitle><date>1998-10-01</date><risdate>1998</risdate><volume>26</volume><issue>5</issue><spage>507</spage><epage>512</epage><pages>507-512</pages><issn>0196-6553</issn><eissn>1527-3296</eissn><abstract>Background: Since the introduction in the 1970s of surgical hand scrub formulations that contain 4% chlorhexidine gluconate (CHG), new surgical scrub formulations that have improved efficacy, persistence, or significantly improved use characteristics have not been forthcoming. In addition, the manufacturer’s labeling for popular hand scrub products generally requires scrub times in excess of 6 minutes, whereas current practical needs call for products with substantially shorter scrub times. A new alcohol-based surgical scrub formulation, which has ingredients that provide emollient, surfactant, and antimicrobial persistence characteristics to complement the rapid and broad-spectrum antiseptic qualities of alcohol, has been developed in an effort to address these current practical needs.
Methods: The relative efficacy of a new alcohol-based surgical scrub formulation that contains ingredients that provide surfactant and antimicrobial persistence characteristics was compared with that of commercial 4% CHG and 7.5% povidone iodine (PVPI) formulations with use of human subjects. Hand antimicrobial count sampling was performed by using standardized “glove juice” methodology.
Results: The efficacy and persistence results of the new formulation showed statistically significant improvement over both CHG and PVPI at a substantially lessened scrub time (3 minutes). In addition, use of the new formulation without a scrub brush produced results statistically similar to 3-minute applications with either a brush or a sponge.
Conclusions: The new alcohol-based formulation demonstrates promise as a new surgical hand scrub formulation with antimicrobial and use characteristics that are significantly improved over current CHG and PVPI formulations. These studies demonstrate the suitability of this formulation for use as a surgical hand scrub and for brushless application. (AJIC Am J Infect Control 1998;26:507-12)</abstract><cop>St. Louis, MO</cop><pub>Mosby, Inc</pub><pmid>9795680</pmid><doi>10.1016/S0196-6553(98)70024-0</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Administration, Topical Alcohols - administration & dosage Alcohols - pharmacology Anti-Infective Agents - administration & dosage Anti-Infective Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiseptics Biological and medical sciences Chlorhexidine - administration & dosage Chlorhexidine - analogs & derivatives Chlorhexidine - pharmacology Consumer Product Safety Dermatologic Agents - pharmacology Hand Disinfection - methods Hand Disinfection - standards Humans Medical sciences Miscellaneous Operating Rooms Pharmacology. Drug treatments Practice Guidelines as Topic Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases United States United States Food and Drug Administration |
| title | Development and evaluation of a new alcohol-based surgical hand scrub formulation with persistent antimicrobial characteristics and brushless application |
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