Solution structure and dynamics of a designed hydrophobic core variant of ubiquitin

Background: The recent merger of computation and protein design has resulted in a burst of success in the generation of novel proteins with native-like properties. A critical component of this coupling between theory and experiment is a detailed analysis of the structures and stabilities of designed...

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Veröffentlicht in:	Structure (London) 1999-08, Vol.7 (8), p.967-976
Hauptverfasser:	Johnson, Eric C, Lazar, Greg A, Desjarlais, John R, Handel, Tracy M
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Amides - chemistry backbone and sidechain dynamics hydrogen–deuterium exchange hydrophobic core packing Models, Molecular Protein Conformation protein design Solutions ubiquitin Ubiquitins - chemistry
Online-Zugang:	Volltext
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