Differences between polyunsaturated fatty acid status of non-institutionalised elderly women and younger controls : a bioconversion defect can be suspected
To evaluate the polyunsaturated fatty acid (PUFA) status in non-institutionalised elderly women and to detect a possible essential fatty acid bioconversion defect. The fatty acid composition of total plasma lipids, plasma triglycerides (TG), cholesterol esters (CE), phospholipids (PL), and erythrocy...
Gespeichert in:
| Veröffentlicht in: | European journal of clinical nutrition 1999-08, Vol.53 (8), p.591-596 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 596 |
|---|---|
| container_issue | 8 |
| container_start_page | 591 |
| container_title | European journal of clinical nutrition |
| container_volume | 53 |
| creator | BABIN, F ABDERRAZIK, M FAVIER, F CRISTOL, J. P LEGER, C. L PAPOZ, L DESCOMPS, B |
| description | To evaluate the polyunsaturated fatty acid (PUFA) status in non-institutionalised elderly women and to detect a possible essential fatty acid bioconversion defect.
The fatty acid composition of total plasma lipids, plasma triglycerides (TG), cholesterol esters (CE), phospholipids (PL), and erythrocytes was determined by capillary column gas-liquid chromatography in a sample of 200 non-institutionalised healthy elderly women over 75 years of age. The data were compared with those of a control group of 50 young female volunteers aged 20-48 y.
In elderly women, the n-6 series precursor, linoleic acid (18:2 n-6), was lower in TG and CE (P = 0.029 and 0.014, respectively). In CE, this fatty acid was highly correlated with vegetable and vegetal fat intakes (P < 0.0001), suggesting a lower dietary supply than in controls. Higher percentages of 16:1 n-7 were found in all the plasma lipid fractions in elderly women, especially in CE (P < 0.0001). The ratios 20:4 n-6/20:3 n-6 and 22:6 n-3/20:5 n-3 were significantly lower in PL from elderly women (P < 0.005 and P < 0.002, respectively), raising the question of the efficiency of the terminal steps of 20:4 n-6 and 22:6 n-3 biosynthesis. Dietary investigations in elderly women indicated that a high dietary protein intake via meat probably contributed to the supply of 20:4 n-6 and thus maintained the status of this fatty acid, despite the suspected altered biosynthesis.
The PUFA status in the elderly women group could be more fragile and dependent on exogenous supply of long-chain PUFAs than previously suspected. |
| doi_str_mv | 10.1038/sj.ejcn.1600792 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70014063</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>45196132</sourcerecordid><originalsourceid>FETCH-LOGICAL-c377t-61e3860efc67e1b8ae9a878d5f5989b0d99d4e37c1decb440d2a5ea7b83be9c63</originalsourceid><addsrcrecordid>eNp1kc-L1TAQx4Mo7tvVszcJunjr26RJk3Zvsv6EBS96LmkykZa-5JlJXfq3-M-a8h4ogqdkZj7zZWa-hLzgbM-ZaG9w2sNkw54rxnRXPyI7LrWqGiXZY7JjXSMrUSoX5BJxYqwUdf2UXHC2faTckV_vRu8hQbCAdID8ABDoMc7rEtDkJZkMjnqT80qNHR3FXLJIo6chhmoMmMe85DEGM49YUJgdpHmlD_FQhExwdI1L-A6J2hhyijPSW2roMMYS_4SEpZU68GAztSaUESgueCwhuGfkiTczwvPze0W-fXj_9e5Tdf_l4-e7t_eVFVrnSnEQrWLgrdLAh9ZAZ1rdusY3XdsNzHWdkyC05Q7sICVztWnA6KEVA3RWiSvy5qR7TPHHApj7w4gW5tkEiAv2ejscU6KAr_8Bp7iksjr2tZK1EjWXG_XqvxTvVNMqrQt0c4JsiogJfH9M48Gktees36ztceo3a_uztaXj5Vl2GQ7g_uJPXhbg-gwYtGb2yQQ74h-uY7JpWvEbCT2w3Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>219658677</pqid></control><display><type>article</type><title>Differences between polyunsaturated fatty acid status of non-institutionalised elderly women and younger controls : a bioconversion defect can be suspected</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Springer Nature - Complete Springer Journals</source><source>Nature Journals Online</source><creator>BABIN, F ; ABDERRAZIK, M ; FAVIER, F ; CRISTOL, J. P ; LEGER, C. L ; PAPOZ, L ; DESCOMPS, B</creator><creatorcontrib>BABIN, F ; ABDERRAZIK, M ; FAVIER, F ; CRISTOL, J. P ; LEGER, C. L ; PAPOZ, L ; DESCOMPS, B</creatorcontrib><description>To evaluate the polyunsaturated fatty acid (PUFA) status in non-institutionalised elderly women and to detect a possible essential fatty acid bioconversion defect.
The fatty acid composition of total plasma lipids, plasma triglycerides (TG), cholesterol esters (CE), phospholipids (PL), and erythrocytes was determined by capillary column gas-liquid chromatography in a sample of 200 non-institutionalised healthy elderly women over 75 years of age. The data were compared with those of a control group of 50 young female volunteers aged 20-48 y.
In elderly women, the n-6 series precursor, linoleic acid (18:2 n-6), was lower in TG and CE (P = 0.029 and 0.014, respectively). In CE, this fatty acid was highly correlated with vegetable and vegetal fat intakes (P < 0.0001), suggesting a lower dietary supply than in controls. Higher percentages of 16:1 n-7 were found in all the plasma lipid fractions in elderly women, especially in CE (P < 0.0001). The ratios 20:4 n-6/20:3 n-6 and 22:6 n-3/20:5 n-3 were significantly lower in PL from elderly women (P < 0.005 and P < 0.002, respectively), raising the question of the efficiency of the terminal steps of 20:4 n-6 and 22:6 n-3 biosynthesis. Dietary investigations in elderly women indicated that a high dietary protein intake via meat probably contributed to the supply of 20:4 n-6 and thus maintained the status of this fatty acid, despite the suspected altered biosynthesis.
The PUFA status in the elderly women group could be more fragile and dependent on exogenous supply of long-chain PUFAs than previously suspected.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/sj.ejcn.1600792</identifier><identifier>PMID: 10477244</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Bioconversion ; Biological and medical sciences ; Biosynthesis ; Cholesterol ; Column chromatography ; Comparative studies ; Defects ; Design defects ; Dietary intake ; Erythrocytes ; Erythrocytes - metabolism ; Esters ; Fatty acid composition ; Fatty acids ; Fatty Acids, Essential - blood ; Fatty Acids, Essential - metabolism ; Fatty Acids, Unsaturated - blood ; Fatty Acids, Unsaturated - metabolism ; Feeding Behavior ; Female ; Humans ; Institutionalization ; Linoleic acid ; Lipids ; Lipids - blood ; Liquid chromatography ; Logistic Models ; Meat ; Medical disorders ; Medical sciences ; Metabolic diseases ; Middle Aged ; Nutrition Assessment ; Older people ; Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) ; Phospholipids ; Polyunsaturated fatty acids ; Triglycerides ; Women</subject><ispartof>European journal of clinical nutrition, 1999-08, Vol.53 (8), p.591-596</ispartof><rights>1999 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. Aug 1999</rights><rights>Macmillan Publishers Limited 1999.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-61e3860efc67e1b8ae9a878d5f5989b0d99d4e37c1decb440d2a5ea7b83be9c63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27915,27916</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1904558$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10477244$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BABIN, F</creatorcontrib><creatorcontrib>ABDERRAZIK, M</creatorcontrib><creatorcontrib>FAVIER, F</creatorcontrib><creatorcontrib>CRISTOL, J. P</creatorcontrib><creatorcontrib>LEGER, C. L</creatorcontrib><creatorcontrib>PAPOZ, L</creatorcontrib><creatorcontrib>DESCOMPS, B</creatorcontrib><title>Differences between polyunsaturated fatty acid status of non-institutionalised elderly women and younger controls : a bioconversion defect can be suspected</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><description>To evaluate the polyunsaturated fatty acid (PUFA) status in non-institutionalised elderly women and to detect a possible essential fatty acid bioconversion defect.
The fatty acid composition of total plasma lipids, plasma triglycerides (TG), cholesterol esters (CE), phospholipids (PL), and erythrocytes was determined by capillary column gas-liquid chromatography in a sample of 200 non-institutionalised healthy elderly women over 75 years of age. The data were compared with those of a control group of 50 young female volunteers aged 20-48 y.
In elderly women, the n-6 series precursor, linoleic acid (18:2 n-6), was lower in TG and CE (P = 0.029 and 0.014, respectively). In CE, this fatty acid was highly correlated with vegetable and vegetal fat intakes (P < 0.0001), suggesting a lower dietary supply than in controls. Higher percentages of 16:1 n-7 were found in all the plasma lipid fractions in elderly women, especially in CE (P < 0.0001). The ratios 20:4 n-6/20:3 n-6 and 22:6 n-3/20:5 n-3 were significantly lower in PL from elderly women (P < 0.005 and P < 0.002, respectively), raising the question of the efficiency of the terminal steps of 20:4 n-6 and 22:6 n-3 biosynthesis. Dietary investigations in elderly women indicated that a high dietary protein intake via meat probably contributed to the supply of 20:4 n-6 and thus maintained the status of this fatty acid, despite the suspected altered biosynthesis.
The PUFA status in the elderly women group could be more fragile and dependent on exogenous supply of long-chain PUFAs than previously suspected.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bioconversion</subject><subject>Biological and medical sciences</subject><subject>Biosynthesis</subject><subject>Cholesterol</subject><subject>Column chromatography</subject><subject>Comparative studies</subject><subject>Defects</subject><subject>Design defects</subject><subject>Dietary intake</subject><subject>Erythrocytes</subject><subject>Erythrocytes - metabolism</subject><subject>Esters</subject><subject>Fatty acid composition</subject><subject>Fatty acids</subject><subject>Fatty Acids, Essential - blood</subject><subject>Fatty Acids, Essential - metabolism</subject><subject>Fatty Acids, Unsaturated - blood</subject><subject>Fatty Acids, Unsaturated - metabolism</subject><subject>Feeding Behavior</subject><subject>Female</subject><subject>Humans</subject><subject>Institutionalization</subject><subject>Linoleic acid</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Liquid chromatography</subject><subject>Logistic Models</subject><subject>Meat</subject><subject>Medical disorders</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Nutrition Assessment</subject><subject>Older people</subject><subject>Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)</subject><subject>Phospholipids</subject><subject>Polyunsaturated fatty acids</subject><subject>Triglycerides</subject><subject>Women</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc-L1TAQx4Mo7tvVszcJunjr26RJk3Zvsv6EBS96LmkykZa-5JlJXfq3-M-a8h4ogqdkZj7zZWa-hLzgbM-ZaG9w2sNkw54rxnRXPyI7LrWqGiXZY7JjXSMrUSoX5BJxYqwUdf2UXHC2faTckV_vRu8hQbCAdID8ABDoMc7rEtDkJZkMjnqT80qNHR3FXLJIo6chhmoMmMe85DEGM49YUJgdpHmlD_FQhExwdI1L-A6J2hhyijPSW2roMMYS_4SEpZU68GAztSaUESgueCwhuGfkiTczwvPze0W-fXj_9e5Tdf_l4-e7t_eVFVrnSnEQrWLgrdLAh9ZAZ1rdusY3XdsNzHWdkyC05Q7sICVztWnA6KEVA3RWiSvy5qR7TPHHApj7w4gW5tkEiAv2ejscU6KAr_8Bp7iksjr2tZK1EjWXG_XqvxTvVNMqrQt0c4JsiogJfH9M48Gktees36ztceo3a_uztaXj5Vl2GQ7g_uJPXhbg-gwYtGb2yQQ74h-uY7JpWvEbCT2w3Q</recordid><startdate>19990801</startdate><enddate>19990801</enddate><creator>BABIN, F</creator><creator>ABDERRAZIK, M</creator><creator>FAVIER, F</creator><creator>CRISTOL, J. P</creator><creator>LEGER, C. L</creator><creator>PAPOZ, L</creator><creator>DESCOMPS, B</creator><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>19990801</creationdate><title>Differences between polyunsaturated fatty acid status of non-institutionalised elderly women and younger controls : a bioconversion defect can be suspected</title><author>BABIN, F ; ABDERRAZIK, M ; FAVIER, F ; CRISTOL, J. P ; LEGER, C. L ; PAPOZ, L ; DESCOMPS, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-61e3860efc67e1b8ae9a878d5f5989b0d99d4e37c1decb440d2a5ea7b83be9c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bioconversion</topic><topic>Biological and medical sciences</topic><topic>Biosynthesis</topic><topic>Cholesterol</topic><topic>Column chromatography</topic><topic>Comparative studies</topic><topic>Defects</topic><topic>Design defects</topic><topic>Dietary intake</topic><topic>Erythrocytes</topic><topic>Erythrocytes - metabolism</topic><topic>Esters</topic><topic>Fatty acid composition</topic><topic>Fatty acids</topic><topic>Fatty Acids, Essential - blood</topic><topic>Fatty Acids, Essential - metabolism</topic><topic>Fatty Acids, Unsaturated - blood</topic><topic>Fatty Acids, Unsaturated - metabolism</topic><topic>Feeding Behavior</topic><topic>Female</topic><topic>Humans</topic><topic>Institutionalization</topic><topic>Linoleic acid</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>Liquid chromatography</topic><topic>Logistic Models</topic><topic>Meat</topic><topic>Medical disorders</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Nutrition Assessment</topic><topic>Older people</topic><topic>Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)</topic><topic>Phospholipids</topic><topic>Polyunsaturated fatty acids</topic><topic>Triglycerides</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BABIN, F</creatorcontrib><creatorcontrib>ABDERRAZIK, M</creatorcontrib><creatorcontrib>FAVIER, F</creatorcontrib><creatorcontrib>CRISTOL, J. P</creatorcontrib><creatorcontrib>LEGER, C. L</creatorcontrib><creatorcontrib>PAPOZ, L</creatorcontrib><creatorcontrib>DESCOMPS, B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BABIN, F</au><au>ABDERRAZIK, M</au><au>FAVIER, F</au><au>CRISTOL, J. P</au><au>LEGER, C. L</au><au>PAPOZ, L</au><au>DESCOMPS, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differences between polyunsaturated fatty acid status of non-institutionalised elderly women and younger controls : a bioconversion defect can be suspected</atitle><jtitle>European journal of clinical nutrition</jtitle><addtitle>Eur J Clin Nutr</addtitle><date>1999-08-01</date><risdate>1999</risdate><volume>53</volume><issue>8</issue><spage>591</spage><epage>596</epage><pages>591-596</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract>To evaluate the polyunsaturated fatty acid (PUFA) status in non-institutionalised elderly women and to detect a possible essential fatty acid bioconversion defect.
The fatty acid composition of total plasma lipids, plasma triglycerides (TG), cholesterol esters (CE), phospholipids (PL), and erythrocytes was determined by capillary column gas-liquid chromatography in a sample of 200 non-institutionalised healthy elderly women over 75 years of age. The data were compared with those of a control group of 50 young female volunteers aged 20-48 y.
In elderly women, the n-6 series precursor, linoleic acid (18:2 n-6), was lower in TG and CE (P = 0.029 and 0.014, respectively). In CE, this fatty acid was highly correlated with vegetable and vegetal fat intakes (P < 0.0001), suggesting a lower dietary supply than in controls. Higher percentages of 16:1 n-7 were found in all the plasma lipid fractions in elderly women, especially in CE (P < 0.0001). The ratios 20:4 n-6/20:3 n-6 and 22:6 n-3/20:5 n-3 were significantly lower in PL from elderly women (P < 0.005 and P < 0.002, respectively), raising the question of the efficiency of the terminal steps of 20:4 n-6 and 22:6 n-3 biosynthesis. Dietary investigations in elderly women indicated that a high dietary protein intake via meat probably contributed to the supply of 20:4 n-6 and thus maintained the status of this fatty acid, despite the suspected altered biosynthesis.
The PUFA status in the elderly women group could be more fragile and dependent on exogenous supply of long-chain PUFAs than previously suspected.</abstract><cop>Basingstoke</cop><pub>Nature Publishing</pub><pmid>10477244</pmid><doi>10.1038/sj.ejcn.1600792</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-3007 |
| ispartof | European journal of clinical nutrition, 1999-08, Vol.53 (8), p.591-596 |
| issn | 0954-3007 1476-5640 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70014063 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature - Complete Springer Journals; Nature Journals Online |
| subjects | Adult Aged Aged, 80 and over Bioconversion Biological and medical sciences Biosynthesis Cholesterol Column chromatography Comparative studies Defects Design defects Dietary intake Erythrocytes Erythrocytes - metabolism Esters Fatty acid composition Fatty acids Fatty Acids, Essential - blood Fatty Acids, Essential - metabolism Fatty Acids, Unsaturated - blood Fatty Acids, Unsaturated - metabolism Feeding Behavior Female Humans Institutionalization Linoleic acid Lipids Lipids - blood Liquid chromatography Logistic Models Meat Medical disorders Medical sciences Metabolic diseases Middle Aged Nutrition Assessment Older people Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) Phospholipids Polyunsaturated fatty acids Triglycerides Women |
| title | Differences between polyunsaturated fatty acid status of non-institutionalised elderly women and younger controls : a bioconversion defect can be suspected |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T04%3A46%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Differences%20between%20polyunsaturated%20fatty%20acid%20status%20of%20non-institutionalised%20elderly%20women%20and%20younger%20controls%20:%20a%20bioconversion%20defect%20can%20be%20suspected&rft.jtitle=European%20journal%20of%20clinical%20nutrition&rft.au=BABIN,%20F&rft.date=1999-08-01&rft.volume=53&rft.issue=8&rft.spage=591&rft.epage=596&rft.pages=591-596&rft.issn=0954-3007&rft.eissn=1476-5640&rft_id=info:doi/10.1038/sj.ejcn.1600792&rft_dat=%3Cproquest_cross%3E45196132%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=219658677&rft_id=info:pmid/10477244&rfr_iscdi=true |