ERK2 Activation by Homocysteine in Vascular Smooth Muscle Cells

Homocysteine at abnormally high levels is an independent risk factor for atherosclerosis and may be a key factor in atherogenesis. Since homocysteine (Hcys) has been shown to promote cell proliferation and induction of the gene transcription factor c-fosin vascular smooth muscle cells (VSMCs), effec...

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Veröffentlicht in:	Biochemical and biophysical research communications 1998-10, Vol.251 (3), p.669-676
Hauptverfasser:	Brown, J.C., Rosenquist, T.H., Monaghan, D.T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen - blood supply Animals Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cells, Cultured Chick Embryo Dizocilpine Maleate - pharmacology Dose-Response Relationship, Drug Enzyme Activation Enzyme Inhibitors - pharmacology Excitatory Amino Acid Antagonists - pharmacology Flavonoids Homocysteine - pharmacology Mitogen-Activated Protein Kinase 1 Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - enzymology Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Signal Transduction Thorax - blood supply
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