A mini-protein designed by removing a module from barnase: molecular modeling and NMR measurements of the conformation

A globular domain can be decomposed into compact modules consisting of contiguous 10–30 amino acid residues. The correlation between modules and exons observed in different proteins suggests that each module was encoded by an ancestral exon and that modules were combined into globular domains by exo...

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Veröffentlicht in:	Protein engineering 1999-08, Vol.12 (8), p.673-680
Hauptverfasser:	Takahashi, Ken-ichi, Noguti, Tosiyuki, Hojo, Hironobu, Yamauchi, Kiyoshi, Kinoshita, Masayoshi, Aimoto, Saburo, Ohkubo, Tadayasu, Gō, Mitiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins barnase Drug Design Magnetic Resonance Spectroscopy mini-protein Models, Molecular molecular modeling NMR Protein Engineering Ribonucleases - chemistry
Online-Zugang:	Volltext
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