Multiple Primary Melanoma
Background. Incidence rates of cutaneous malignant melanoma (CMM) have been increasing for decades among Caucasian populations worldwide. Multiple factors identify persons at increased risk of CMM, including those with a family history of melanoma and those with atypical moles. Approximately 6–12% o...
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| Veröffentlicht in: | Dermatologic surgery 1999-07, Vol.25 (7), p.576-581 |
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| container_title | Dermatologic surgery |
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| creator | Conrad, Nicole Leis, Paula Orengo, Ida Medrano, Estela E. Hayes, Teresa G. Baer, Susan Rosen, Theodore |
| description | Background. Incidence rates of cutaneous malignant melanoma (CMM) have been increasing for decades among Caucasian populations worldwide. Multiple factors identify persons at increased risk of CMM, including those with a family history of melanoma and those with atypical moles. Approximately 6–12% of melanomas are familial and approximately 12% of patients with familial melanoma have multiple primary melanomas.
Objective. To report a case of a patient with atypical moles and with 17 multiple primary melanomas. To review the literature on multiple primary melanomas as well as to review the genetics and treatment of melanoma.
Conclusion. Patients with numerous atypical moles and a family or personal history of melanoma are at greatest risk for developing CMM. Patients from this population tend to develop CMM approximately 10 years earlier than the general population and have an increased risk for developing multiple primary melanomas. Since genetic tests capable of detecting individuals with an inherited susceptibility to CMM are not available, it is important to identify those patients with an increased risk and monitor them closely with regular total‐body examinations. |
| doi_str_mv | 10.1046/j.1524-4725.1999.98050.x |
| format | Article |
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Objective. To report a case of a patient with atypical moles and with 17 multiple primary melanomas. To review the literature on multiple primary melanomas as well as to review the genetics and treatment of melanoma.
Conclusion. Patients with numerous atypical moles and a family or personal history of melanoma are at greatest risk for developing CMM. Patients from this population tend to develop CMM approximately 10 years earlier than the general population and have an increased risk for developing multiple primary melanomas. Since genetic tests capable of detecting individuals with an inherited susceptibility to CMM are not available, it is important to identify those patients with an increased risk and monitor them closely with regular total‐body examinations.</description><identifier>ISSN: 1076-0512</identifier><identifier>EISSN: 1524-4725</identifier><identifier>DOI: 10.1046/j.1524-4725.1999.98050.x</identifier><identifier>PMID: 10469118</identifier><language>eng</language><publisher>Boston, MA, USA: Blackwell Science Inc</publisher><subject>Biological and medical sciences ; Biopsy ; Dermatologic Surgical Procedures ; Dermatology ; Humans ; Male ; Medical sciences ; Melanoma - genetics ; Melanoma - pathology ; Melanoma - surgery ; Middle Aged ; Neoplasm Invasiveness ; Neoplasms, Multiple Primary - genetics ; Neoplasms, Multiple Primary - pathology ; Neoplasms, Multiple Primary - surgery ; Skin - pathology ; Skin Neoplasms - genetics ; Skin Neoplasms - pathology ; Skin Neoplasms - surgery ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>Dermatologic surgery, 1999-07, Vol.25 (7), p.576-581</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3950-fb5c02a9bee2cfd158a92b1f4c20301a61b86e14be05acbb4ec7730860076e473</citedby><cites>FETCH-LOGICAL-c3950-fb5c02a9bee2cfd158a92b1f4c20301a61b86e14be05acbb4ec7730860076e473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1524-4725.1999.98050.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1524-4725.1999.98050.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1888223$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10469118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Conrad, Nicole</creatorcontrib><creatorcontrib>Leis, Paula</creatorcontrib><creatorcontrib>Orengo, Ida</creatorcontrib><creatorcontrib>Medrano, Estela E.</creatorcontrib><creatorcontrib>Hayes, Teresa G.</creatorcontrib><creatorcontrib>Baer, Susan</creatorcontrib><creatorcontrib>Rosen, Theodore</creatorcontrib><title>Multiple Primary Melanoma</title><title>Dermatologic surgery</title><addtitle>Dermatol Surg</addtitle><description>Background. Incidence rates of cutaneous malignant melanoma (CMM) have been increasing for decades among Caucasian populations worldwide. Multiple factors identify persons at increased risk of CMM, including those with a family history of melanoma and those with atypical moles. Approximately 6–12% of melanomas are familial and approximately 12% of patients with familial melanoma have multiple primary melanomas.
Objective. To report a case of a patient with atypical moles and with 17 multiple primary melanomas. To review the literature on multiple primary melanomas as well as to review the genetics and treatment of melanoma.
Conclusion. Patients with numerous atypical moles and a family or personal history of melanoma are at greatest risk for developing CMM. Patients from this population tend to develop CMM approximately 10 years earlier than the general population and have an increased risk for developing multiple primary melanomas. Since genetic tests capable of detecting individuals with an inherited susceptibility to CMM are not available, it is important to identify those patients with an increased risk and monitor them closely with regular total‐body examinations.</description><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Dermatologic Surgical Procedures</subject><subject>Dermatology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Melanoma - genetics</subject><subject>Melanoma - pathology</subject><subject>Melanoma - surgery</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasms, Multiple Primary - genetics</subject><subject>Neoplasms, Multiple Primary - pathology</subject><subject>Neoplasms, Multiple Primary - surgery</subject><subject>Skin - pathology</subject><subject>Skin Neoplasms - genetics</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin Neoplasms - surgery</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>1076-0512</issn><issn>1524-4725</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE9PwzAMxSMEYjD4AFzQDohbi50mbXJBQuOvtAkk2DlKslTq1K6jWcX27UnXCThysiX_bL_3CBkhxAgsvVnEyCmLWEZ5jFLKWArgEG8OyMnP4DD0kKURcKQDcur9AgCpTOCYDLojElGckItpW66LVelGb01R6WY7mrpSL-tKn5GjXJfene_rkMweHz7Gz9Hk9ellfDeJbCI5RLnhFqiWxjlq8zlyoSU1mDNLIQHUKRqROmTGAdfWGOZsliUgUgjiHMuSIbnu766a-rN1fq2qwltXBhWubr3KOtkMaQBFD9qm9r5xuVr1khWC6hyphercq8696mJRu1jUJqxe7n-0pnLzP4t9DgG42gPaW13mjV7awv9yQghKk4Dd9thXUbrtv_-r-_fZrk2-AcIye9w</recordid><startdate>199907</startdate><enddate>199907</enddate><creator>Conrad, Nicole</creator><creator>Leis, Paula</creator><creator>Orengo, Ida</creator><creator>Medrano, Estela E.</creator><creator>Hayes, Teresa G.</creator><creator>Baer, Susan</creator><creator>Rosen, Theodore</creator><general>Blackwell Science Inc</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199907</creationdate><title>Multiple Primary Melanoma</title><author>Conrad, Nicole ; Leis, Paula ; Orengo, Ida ; Medrano, Estela E. ; Hayes, Teresa G. ; Baer, Susan ; Rosen, Theodore</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3950-fb5c02a9bee2cfd158a92b1f4c20301a61b86e14be05acbb4ec7730860076e473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Dermatologic Surgical Procedures</topic><topic>Dermatology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Melanoma - genetics</topic><topic>Melanoma - pathology</topic><topic>Melanoma - surgery</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasms, Multiple Primary - genetics</topic><topic>Neoplasms, Multiple Primary - pathology</topic><topic>Neoplasms, Multiple Primary - surgery</topic><topic>Skin - pathology</topic><topic>Skin Neoplasms - genetics</topic><topic>Skin Neoplasms - pathology</topic><topic>Skin Neoplasms - surgery</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Conrad, Nicole</creatorcontrib><creatorcontrib>Leis, Paula</creatorcontrib><creatorcontrib>Orengo, Ida</creatorcontrib><creatorcontrib>Medrano, Estela E.</creatorcontrib><creatorcontrib>Hayes, Teresa G.</creatorcontrib><creatorcontrib>Baer, Susan</creatorcontrib><creatorcontrib>Rosen, Theodore</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Dermatologic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Conrad, Nicole</au><au>Leis, Paula</au><au>Orengo, Ida</au><au>Medrano, Estela E.</au><au>Hayes, Teresa G.</au><au>Baer, Susan</au><au>Rosen, Theodore</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multiple Primary Melanoma</atitle><jtitle>Dermatologic surgery</jtitle><addtitle>Dermatol Surg</addtitle><date>1999-07</date><risdate>1999</risdate><volume>25</volume><issue>7</issue><spage>576</spage><epage>581</epage><pages>576-581</pages><issn>1076-0512</issn><eissn>1524-4725</eissn><abstract>Background. Incidence rates of cutaneous malignant melanoma (CMM) have been increasing for decades among Caucasian populations worldwide. Multiple factors identify persons at increased risk of CMM, including those with a family history of melanoma and those with atypical moles. Approximately 6–12% of melanomas are familial and approximately 12% of patients with familial melanoma have multiple primary melanomas.
Objective. To report a case of a patient with atypical moles and with 17 multiple primary melanomas. To review the literature on multiple primary melanomas as well as to review the genetics and treatment of melanoma.
Conclusion. Patients with numerous atypical moles and a family or personal history of melanoma are at greatest risk for developing CMM. Patients from this population tend to develop CMM approximately 10 years earlier than the general population and have an increased risk for developing multiple primary melanomas. Since genetic tests capable of detecting individuals with an inherited susceptibility to CMM are not available, it is important to identify those patients with an increased risk and monitor them closely with regular total‐body examinations.</abstract><cop>Boston, MA, USA</cop><pub>Blackwell Science Inc</pub><pmid>10469118</pmid><doi>10.1046/j.1524-4725.1999.98050.x</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Journals@Ovid Complete |
| subjects | Biological and medical sciences Biopsy Dermatologic Surgical Procedures Dermatology Humans Male Medical sciences Melanoma - genetics Melanoma - pathology Melanoma - surgery Middle Aged Neoplasm Invasiveness Neoplasms, Multiple Primary - genetics Neoplasms, Multiple Primary - pathology Neoplasms, Multiple Primary - surgery Skin - pathology Skin Neoplasms - genetics Skin Neoplasms - pathology Skin Neoplasms - surgery Tumors of the skin and soft tissue. Premalignant lesions |
| title | Multiple Primary Melanoma |
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