A systematic review of Helicobacter pylori eradication therapy—the impact of antimicrobial resistance on eradication rates
Background : We systematically reviewed all available data in the literature to determine the overall eradication rates of currently advised Helicobacter pylori eradication regimens and to resolve conflicting evidence on the impact of antimicrobial resistance on the eradication rates. Methods : A co...
Gespeichert in:
| Veröffentlicht in: | Alimentary pharmacology & therapeutics 1999-08, Vol.13 (8), p.1047-1055 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1055 |
|---|---|
| container_issue | 8 |
| container_start_page | 1047 |
| container_title | Alimentary pharmacology & therapeutics |
| container_volume | 13 |
| creator | Houben Beek, D. Van De Hensen Craen, A. J. M. De Rauws Tytgat |
| description | Background
: We systematically reviewed all available data in the literature to determine the overall eradication rates of currently advised Helicobacter pylori eradication regimens and to resolve conflicting evidence on the impact of antimicrobial resistance on the eradication rates.
Methods
: A comprehensive search of all published trials on H. pylori eradication therapy was carried out via an electronic database search, hand‐searching and checking reference lists of pharmaceutical companies and other reviews. Full papers and s in the English language which study currently advised eradication regimes were included.
Results
: 770 study‐arms were analysed. Mean eradication rates for bismuth based triple, proton pump inhibitor triple, quadruple and ranitidine bismuth citrate combination therapies vary from 65 to 92%. In case of nitroimidazole resistance, a drop in efficacy of up to 50% was found for bismuth‐based triple and proton pump inhibitor‐based triple therapies. For quadruple therapy, a significant difference in efficacy was found in the equal‐effects analysis; however, this could not be confirmed in the random‐effects analysis. In case of clarithromycin resistance, a mean drop in efficacy of 56% was found for one‐ and two‐week clarithromycin containing proton pump inhibitor‐triple therapies and of 58% for two‐week ranitidine bismuth citrate combined with clarithromycin therapies. For ranitidine bismuth citrate combined with clarithromycin and nitroimidazole, no difference in efficacy was found in case of nitroimidazole or clarithromycin resistance, but data are still scarce.
Conclusions
: The cure rate with most regimens dropped significantly, in case of nitroimidazole‐resistant strains, compared to nitroimidazole‐susceptible strains. In case of clarithromycin resistance, the efficacy of most regimens is also decreased; however, data are still scarce. These data should allow physicians to make a better choice of an appropriate therapy for their patients. |
| doi_str_mv | 10.1046/j.1365-2036.1999.00555.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70012128</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70012128</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4595-b998f48ffa4a90ab0978c7f2c6f80059507a0445c37866c61bd126b12e0f3d1d3</originalsourceid><addsrcrecordid>eNqNkMFO3DAQhi0EYrfAK1Q-IG5Jx07s2FIvK0ShElI5LGfLcWzVq2ST2lkgUg99iD4hT1KHXbUce_JY8_0zmg8hTCAnUPJPm5wUnGUUCp4TKWUOwBjLX47Q8m_jGC2BcplRQYoF-hDjBgB4BfQULeYhggtYop8rHKc42k6P3uBgn7x9xr3Dd7b1pq-1GW3Aw9T2wWMbdONNAvstHr-n3zC9_vqdKuy7IZFzTm9H33kT-trrNs2LPo56ayxOmff5oEcbz9GJ0220F4f3DD1-uVlf32X3326_Xq_uM1MyybJaSuFK4ZwutQRdg6yEqRw13Il0uGRQaShLZopKcG44qRtCeU2oBVc0pCnO0NV-7hD6HzsbR9X5aGzb6q3td1FVAIQSKhIo9mA6IMZgnRqC73SYFAE1S1MbNQtWs2A1m1dv5tVLin487NjVnW3eBfeqE3B5AHQ0unUhafHxHyckqQqWsM977Nm3dvrv_Wr1sE5F8Qfs3KG7</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70012128</pqid></control><display><type>article</type><title>A systematic review of Helicobacter pylori eradication therapy—the impact of antimicrobial resistance on eradication rates</title><source>IngentaConnect Backfiles</source><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><source>Wiley Online Library</source><source>EZB Electronic Journals Library</source><creator>Houben ; Beek, D. Van De ; Hensen ; Craen, A. J. M. De ; Rauws ; Tytgat</creator><creatorcontrib>Houben ; Beek, D. Van De ; Hensen ; Craen, A. J. M. De ; Rauws ; Tytgat</creatorcontrib><description>Background
: We systematically reviewed all available data in the literature to determine the overall eradication rates of currently advised Helicobacter pylori eradication regimens and to resolve conflicting evidence on the impact of antimicrobial resistance on the eradication rates.
Methods
: A comprehensive search of all published trials on H. pylori eradication therapy was carried out via an electronic database search, hand‐searching and checking reference lists of pharmaceutical companies and other reviews. Full papers and s in the English language which study currently advised eradication regimes were included.
Results
: 770 study‐arms were analysed. Mean eradication rates for bismuth based triple, proton pump inhibitor triple, quadruple and ranitidine bismuth citrate combination therapies vary from 65 to 92%. In case of nitroimidazole resistance, a drop in efficacy of up to 50% was found for bismuth‐based triple and proton pump inhibitor‐based triple therapies. For quadruple therapy, a significant difference in efficacy was found in the equal‐effects analysis; however, this could not be confirmed in the random‐effects analysis. In case of clarithromycin resistance, a mean drop in efficacy of 56% was found for one‐ and two‐week clarithromycin containing proton pump inhibitor‐triple therapies and of 58% for two‐week ranitidine bismuth citrate combined with clarithromycin therapies. For ranitidine bismuth citrate combined with clarithromycin and nitroimidazole, no difference in efficacy was found in case of nitroimidazole or clarithromycin resistance, but data are still scarce.
Conclusions
: The cure rate with most regimens dropped significantly, in case of nitroimidazole‐resistant strains, compared to nitroimidazole‐susceptible strains. In case of clarithromycin resistance, the efficacy of most regimens is also decreased; however, data are still scarce. These data should allow physicians to make a better choice of an appropriate therapy for their patients.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1046/j.1365-2036.1999.00555.x</identifier><identifier>PMID: 10468680</identifier><language>eng</language><publisher>Oxford UK: Blackwell Science Ltd</publisher><subject>Anti-Bacterial Agents - therapeutic use ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Digestive system ; Drug Resistance, Microbial ; Helicobacter Infections - drug therapy ; Helicobacter Infections - microbiology ; Helicobacter pylori - drug effects ; Humans ; Medical sciences ; Pharmacology. Drug treatments</subject><ispartof>Alimentary pharmacology & therapeutics, 1999-08, Vol.13 (8), p.1047-1055</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4595-b998f48ffa4a90ab0978c7f2c6f80059507a0445c37866c61bd126b12e0f3d1d3</citedby><cites>FETCH-LOGICAL-c4595-b998f48ffa4a90ab0978c7f2c6f80059507a0445c37866c61bd126b12e0f3d1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2036.1999.00555.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2036.1999.00555.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,1432,27922,27923,45572,45573,46407,46831</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1891735$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10468680$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Houben</creatorcontrib><creatorcontrib>Beek, D. Van De</creatorcontrib><creatorcontrib>Hensen</creatorcontrib><creatorcontrib>Craen, A. J. M. De</creatorcontrib><creatorcontrib>Rauws</creatorcontrib><creatorcontrib>Tytgat</creatorcontrib><title>A systematic review of Helicobacter pylori eradication therapy—the impact of antimicrobial resistance on eradication rates</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Background
: We systematically reviewed all available data in the literature to determine the overall eradication rates of currently advised Helicobacter pylori eradication regimens and to resolve conflicting evidence on the impact of antimicrobial resistance on the eradication rates.
Methods
: A comprehensive search of all published trials on H. pylori eradication therapy was carried out via an electronic database search, hand‐searching and checking reference lists of pharmaceutical companies and other reviews. Full papers and s in the English language which study currently advised eradication regimes were included.
Results
: 770 study‐arms were analysed. Mean eradication rates for bismuth based triple, proton pump inhibitor triple, quadruple and ranitidine bismuth citrate combination therapies vary from 65 to 92%. In case of nitroimidazole resistance, a drop in efficacy of up to 50% was found for bismuth‐based triple and proton pump inhibitor‐based triple therapies. For quadruple therapy, a significant difference in efficacy was found in the equal‐effects analysis; however, this could not be confirmed in the random‐effects analysis. In case of clarithromycin resistance, a mean drop in efficacy of 56% was found for one‐ and two‐week clarithromycin containing proton pump inhibitor‐triple therapies and of 58% for two‐week ranitidine bismuth citrate combined with clarithromycin therapies. For ranitidine bismuth citrate combined with clarithromycin and nitroimidazole, no difference in efficacy was found in case of nitroimidazole or clarithromycin resistance, but data are still scarce.
Conclusions
: The cure rate with most regimens dropped significantly, in case of nitroimidazole‐resistant strains, compared to nitroimidazole‐susceptible strains. In case of clarithromycin resistance, the efficacy of most regimens is also decreased; however, data are still scarce. These data should allow physicians to make a better choice of an appropriate therapy for their patients.</description><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Digestive system</subject><subject>Drug Resistance, Microbial</subject><subject>Helicobacter Infections - drug therapy</subject><subject>Helicobacter Infections - microbiology</subject><subject>Helicobacter pylori - drug effects</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMFO3DAQhi0EYrfAK1Q-IG5Jx07s2FIvK0ShElI5LGfLcWzVq2ST2lkgUg99iD4hT1KHXbUce_JY8_0zmg8hTCAnUPJPm5wUnGUUCp4TKWUOwBjLX47Q8m_jGC2BcplRQYoF-hDjBgB4BfQULeYhggtYop8rHKc42k6P3uBgn7x9xr3Dd7b1pq-1GW3Aw9T2wWMbdONNAvstHr-n3zC9_vqdKuy7IZFzTm9H33kT-trrNs2LPo56ayxOmff5oEcbz9GJ0220F4f3DD1-uVlf32X3326_Xq_uM1MyybJaSuFK4ZwutQRdg6yEqRw13Il0uGRQaShLZopKcG44qRtCeU2oBVc0pCnO0NV-7hD6HzsbR9X5aGzb6q3td1FVAIQSKhIo9mA6IMZgnRqC73SYFAE1S1MbNQtWs2A1m1dv5tVLin487NjVnW3eBfeqE3B5AHQ0unUhafHxHyckqQqWsM977Nm3dvrv_Wr1sE5F8Qfs3KG7</recordid><startdate>199908</startdate><enddate>199908</enddate><creator>Houben</creator><creator>Beek, D. Van De</creator><creator>Hensen</creator><creator>Craen, A. J. M. De</creator><creator>Rauws</creator><creator>Tytgat</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199908</creationdate><title>A systematic review of Helicobacter pylori eradication therapy—the impact of antimicrobial resistance on eradication rates</title><author>Houben ; Beek, D. Van De ; Hensen ; Craen, A. J. M. De ; Rauws ; Tytgat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4595-b998f48ffa4a90ab0978c7f2c6f80059507a0445c37866c61bd126b12e0f3d1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Digestive system</topic><topic>Drug Resistance, Microbial</topic><topic>Helicobacter Infections - drug therapy</topic><topic>Helicobacter Infections - microbiology</topic><topic>Helicobacter pylori - drug effects</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Houben</creatorcontrib><creatorcontrib>Beek, D. Van De</creatorcontrib><creatorcontrib>Hensen</creatorcontrib><creatorcontrib>Craen, A. J. M. De</creatorcontrib><creatorcontrib>Rauws</creatorcontrib><creatorcontrib>Tytgat</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Houben</au><au>Beek, D. Van De</au><au>Hensen</au><au>Craen, A. J. M. De</au><au>Rauws</au><au>Tytgat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A systematic review of Helicobacter pylori eradication therapy—the impact of antimicrobial resistance on eradication rates</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>1999-08</date><risdate>1999</risdate><volume>13</volume><issue>8</issue><spage>1047</spage><epage>1055</epage><pages>1047-1055</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>Background
: We systematically reviewed all available data in the literature to determine the overall eradication rates of currently advised Helicobacter pylori eradication regimens and to resolve conflicting evidence on the impact of antimicrobial resistance on the eradication rates.
Methods
: A comprehensive search of all published trials on H. pylori eradication therapy was carried out via an electronic database search, hand‐searching and checking reference lists of pharmaceutical companies and other reviews. Full papers and s in the English language which study currently advised eradication regimes were included.
Results
: 770 study‐arms were analysed. Mean eradication rates for bismuth based triple, proton pump inhibitor triple, quadruple and ranitidine bismuth citrate combination therapies vary from 65 to 92%. In case of nitroimidazole resistance, a drop in efficacy of up to 50% was found for bismuth‐based triple and proton pump inhibitor‐based triple therapies. For quadruple therapy, a significant difference in efficacy was found in the equal‐effects analysis; however, this could not be confirmed in the random‐effects analysis. In case of clarithromycin resistance, a mean drop in efficacy of 56% was found for one‐ and two‐week clarithromycin containing proton pump inhibitor‐triple therapies and of 58% for two‐week ranitidine bismuth citrate combined with clarithromycin therapies. For ranitidine bismuth citrate combined with clarithromycin and nitroimidazole, no difference in efficacy was found in case of nitroimidazole or clarithromycin resistance, but data are still scarce.
Conclusions
: The cure rate with most regimens dropped significantly, in case of nitroimidazole‐resistant strains, compared to nitroimidazole‐susceptible strains. In case of clarithromycin resistance, the efficacy of most regimens is also decreased; however, data are still scarce. These data should allow physicians to make a better choice of an appropriate therapy for their patients.</abstract><cop>Oxford UK</cop><pub>Blackwell Science Ltd</pub><pmid>10468680</pmid><doi>10.1046/j.1365-2036.1999.00555.x</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0269-2813 |
| ispartof | Alimentary pharmacology & therapeutics, 1999-08, Vol.13 (8), p.1047-1055 |
| issn | 0269-2813 1365-2036 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70012128 |
| source | IngentaConnect Backfiles; Wiley Online Library - AutoHoldings Journals; MEDLINE; Wiley Online Library; EZB Electronic Journals Library |
| subjects | Anti-Bacterial Agents - therapeutic use Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Digestive system Drug Resistance, Microbial Helicobacter Infections - drug therapy Helicobacter Infections - microbiology Helicobacter pylori - drug effects Humans Medical sciences Pharmacology. Drug treatments |
| title | A systematic review of Helicobacter pylori eradication therapy—the impact of antimicrobial resistance on eradication rates |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T17%3A10%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20systematic%20review%20of%20Helicobacter%20pylori%20eradication%20therapy%E2%80%94the%20impact%20of%20antimicrobial%20resistance%20on%20eradication%20rates&rft.jtitle=Alimentary%20pharmacology%20&%20therapeutics&rft.au=Houben&rft.date=1999-08&rft.volume=13&rft.issue=8&rft.spage=1047&rft.epage=1055&rft.pages=1047-1055&rft.issn=0269-2813&rft.eissn=1365-2036&rft_id=info:doi/10.1046/j.1365-2036.1999.00555.x&rft_dat=%3Cproquest_cross%3E70012128%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70012128&rft_id=info:pmid/10468680&rfr_iscdi=true |