In vivo lactate and β-hydroxybutyrate editing using a pure-phase refocusing pulse train
A refocusing pulse train consisting of a semiselective refo cusing pulse and a selective inversion pulse to obtain a pure‐phase refocusing at the frequency of maximal excitation of the semiselective refocusing pulse is proposed and applied to in vivo lactate and β‐hydroxybutyrate editing using diffe...
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| Veröffentlicht in: | Magnetic resonance in medicine 1998-11, Vol.40 (5), p.783-788 |
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| container_title | Magnetic resonance in medicine |
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| creator | Shen, Jun Novotny, Edward J. Rothman, Douglas L. |
| description | A refocusing pulse train consisting of a semiselective refo cusing pulse and a selective inversion pulse to obtain a pure‐phase refocusing at the frequency of maximal excitation of the semiselective refocusing pulse is proposed and applied to in vivo lactate and β‐hydroxybutyrate editing using difference spectroscopy. It is shown, using both rotation matrix theory and phantom experiments, that the soft inversion pulse has to be halved to flank the semiselective pulse to obtain perfect refocusing and cancellation of interfering resonances. The editing method is used to obtain lactate and β‐hydroxybu‐tyrate spectra from the occipital cortex of juvenile epilepsy patients before and after ketogenic diet treatment. |
| doi_str_mv | 10.1002/mrm.1910400520 |
| format | Article |
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It is shown, using both rotation matrix theory and phantom experiments, that the soft inversion pulse has to be halved to flank the semiselective pulse to obtain perfect refocusing and cancellation of interfering resonances. 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Reson. Med</addtitle><description>A refocusing pulse train consisting of a semiselective refo cusing pulse and a selective inversion pulse to obtain a pure‐phase refocusing at the frequency of maximal excitation of the semiselective refocusing pulse is proposed and applied to in vivo lactate and β‐hydroxybutyrate editing using difference spectroscopy. It is shown, using both rotation matrix theory and phantom experiments, that the soft inversion pulse has to be halved to flank the semiselective pulse to obtain perfect refocusing and cancellation of interfering resonances. The editing method is used to obtain lactate and β‐hydroxybu‐tyrate spectra from the occipital cortex of juvenile epilepsy patients before and after ketogenic diet treatment.</description><subject>1H MRS</subject><subject>3-Hydroxybutyric Acid - analysis</subject><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Epilepsy - diagnosis</subject><subject>Epilepsy - diet therapy</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>J-modulation inhibition</subject><subject>Lactic Acid - analysis</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Medical sciences</subject><subject>Models, Theoretical</subject><subject>Nervous system</subject><subject>Occipital Lobe - chemistry</subject><subject>Occipital Lobe - pathology</subject><subject>off-resonance effect</subject><subject>Phantoms, Imaging</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Reference Values</subject><subject>rotation matrix</subject><subject>Sensitivity and Specificity</subject><subject>Signal Processing, Computer-Assisted</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUMtuFDEQtBAoLIErN6Q5oNxmab_G4yNEIQkkREI89mZ5bA8xzCv2TJL5LT6Eb8KrWS3ilEu3urqqulUIvcSwxgDkTRvaNZYYGAAn8AitMCckJ1yyx2gFgkFOsWRP0bMYfwKAlIIdoAMppMAFXaHNeZfd-ts-a7QZ9egy3dnsz-_8erahv5-raZzDFnbWj777kU1xW3U2TMHlw7WOLguu7s2CD1OTgDFo3z1HT2qdphe7foi-vj_5cnyWX1ydnh-_vcgNAwG5qSh2gtPamrqWmKVREF1qC1w4WwIpcGVFWWPKnS0sYxUrtNS0kLxMOkYP0dHiO4T-ZnJxVK2PxjWN7lw_RSUAMBSSJuJ6IZrQx5ieVkPwrQ6zwqC2UaoUpfoXZRK82jlPVevsnr7LLu1f7_Y6Gt3UQXfGxz2NMAaUb23kQrvzjZsfOKouP1_-90K-aH0c3f1eq8MvVQgquPr-6VR9LDnZfNi8U9_oX-BrnNw</recordid><startdate>199811</startdate><enddate>199811</enddate><creator>Shen, Jun</creator><creator>Novotny, Edward J.</creator><creator>Rothman, Douglas L.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Williams & Wilkins</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199811</creationdate><title>In vivo lactate and β-hydroxybutyrate editing using a pure-phase refocusing pulse train</title><author>Shen, Jun ; Novotny, Edward J. ; Rothman, Douglas L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4070-cb31e753fdcff914b3172a8ad057ed80261bd78f135ed6d44b46a9a36958e7543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>1H MRS</topic><topic>3-Hydroxybutyric Acid - analysis</topic><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Epilepsy - diagnosis</topic><topic>Epilepsy - diet therapy</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>J-modulation inhibition</topic><topic>Lactic Acid - analysis</topic><topic>Magnetic Resonance Spectroscopy - methods</topic><topic>Medical sciences</topic><topic>Models, Theoretical</topic><topic>Nervous system</topic><topic>Occipital Lobe - chemistry</topic><topic>Occipital Lobe - pathology</topic><topic>off-resonance effect</topic><topic>Phantoms, Imaging</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Reference Values</topic><topic>rotation matrix</topic><topic>Sensitivity and Specificity</topic><topic>Signal Processing, Computer-Assisted</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shen, Jun</creatorcontrib><creatorcontrib>Novotny, Edward J.</creatorcontrib><creatorcontrib>Rothman, Douglas L.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shen, Jun</au><au>Novotny, Edward J.</au><au>Rothman, Douglas L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo lactate and β-hydroxybutyrate editing using a pure-phase refocusing pulse train</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn. Reson. Med</addtitle><date>1998-11</date><risdate>1998</risdate><volume>40</volume><issue>5</issue><spage>783</spage><epage>788</epage><pages>783-788</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><coden>MRMEEN</coden><abstract>A refocusing pulse train consisting of a semiselective refo cusing pulse and a selective inversion pulse to obtain a pure‐phase refocusing at the frequency of maximal excitation of the semiselective refocusing pulse is proposed and applied to in vivo lactate and β‐hydroxybutyrate editing using difference spectroscopy. It is shown, using both rotation matrix theory and phantom experiments, that the soft inversion pulse has to be halved to flank the semiselective pulse to obtain perfect refocusing and cancellation of interfering resonances. 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| ispartof | Magnetic resonance in medicine, 1998-11, Vol.40 (5), p.783-788 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | 1H MRS 3-Hydroxybutyric Acid - analysis Adolescent Biological and medical sciences Child Epilepsy - diagnosis Epilepsy - diet therapy Humans Investigative techniques, diagnostic techniques (general aspects) J-modulation inhibition Lactic Acid - analysis Magnetic Resonance Spectroscopy - methods Medical sciences Models, Theoretical Nervous system Occipital Lobe - chemistry Occipital Lobe - pathology off-resonance effect Phantoms, Imaging Radiodiagnosis. Nmr imagery. Nmr spectrometry Reference Values rotation matrix Sensitivity and Specificity Signal Processing, Computer-Assisted |
| title | In vivo lactate and β-hydroxybutyrate editing using a pure-phase refocusing pulse train |
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