Diaminodiphenylsulfone resistance of Mycobacterium leprae due to mutations in the dihydropteroate synthase gene
Abstract The nucleotide sequence analysis of the dihydropteroate synthase (DHPS) gene of six diaminodiphenylsulfone-resistant Mycobacterium leprae strains revealed that the mutation was limited at highly conserved amino acid residues 53 or 55. Though the mutation at amino acid residue 55 or its homo...
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| Veröffentlicht in: | FEMS microbiology letters 1999-08, Vol.177 (2), p.231-235 |
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| container_title | FEMS microbiology letters |
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| creator | Kai, Masanori Matsuoka, Masanori Nakata, Noboru Maeda, Shinji Gidoh, Masaichi Maeda, Yumi Hashimoto, Ken Kobayashi, Kazuo Kashiwabara, Yoshiko |
| description | Abstract
The nucleotide sequence analysis of the dihydropteroate synthase (DHPS) gene of six diaminodiphenylsulfone-resistant Mycobacterium leprae strains revealed that the mutation was limited at highly conserved amino acid residues 53 or 55. Though the mutation at amino acid residue 55 or its homologous site has been reported in other bacteria, the mutation at residue 53 is the first case in bacteria. This is the first paper which links the mutations in DHPS and sulfonamide resistance in M. leprae. This finding is medically and socially relevant, since leprosy is still a big problem in certain regions. |
| doi_str_mv | 10.1111/j.1574-6968.1999.tb13737.x |
| format | Article |
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The nucleotide sequence analysis of the dihydropteroate synthase (DHPS) gene of six diaminodiphenylsulfone-resistant Mycobacterium leprae strains revealed that the mutation was limited at highly conserved amino acid residues 53 or 55. Though the mutation at amino acid residue 55 or its homologous site has been reported in other bacteria, the mutation at residue 53 is the first case in bacteria. This is the first paper which links the mutations in DHPS and sulfonamide resistance in M. leprae. This finding is medically and socially relevant, since leprosy is still a big problem in certain regions.</description><identifier>ISSN: 0378-1097</identifier><identifier>EISSN: 1574-6968</identifier><identifier>DOI: 10.1111/j.1574-6968.1999.tb13737.x</identifier><identifier>PMID: 10474189</identifier><identifier>CODEN: FMLED7</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Amino acids ; Bacteria ; Bacteriology ; Biological and medical sciences ; Chemotherapy ; Dapsone - pharmacology ; Diaminodiphenylsulfone ; Dihydropteroate synthase ; Dihydropteroate Synthase - genetics ; Drug resistance ; Drug Resistance, Microbial - genetics ; Folic Acid Antagonists - pharmacology ; Fundamental and applied biological sciences. Psychology ; Genes, Bacterial ; Genetic mutation ; Genetics ; Homology ; Leprostatic Agents - pharmacology ; Leprosy ; Leprosy - microbiology ; Microbiology ; Molecular Sequence Data ; Mutation ; Mycobacterium leprae ; Mycobacterium leprae - drug effects ; Mycobacterium leprae - enzymology ; Mycobacterium leprae - genetics ; Nucleotide sequence ; Nucleotides ; Sulfonamides</subject><ispartof>FEMS microbiology letters, 1999-08, Vol.177 (2), p.231-235</ispartof><rights>1999 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved. 1999</rights><rights>1999 INIST-CNRS</rights><rights>1999 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4361-5ea86f5daceb7a9adc97c3211ec150710505878605b3220e401ed38742fc8bb53</citedby><cites>FETCH-LOGICAL-c4361-5ea86f5daceb7a9adc97c3211ec150710505878605b3220e401ed38742fc8bb53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1574-6968.1999.tb13737.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1574-6968.1999.tb13737.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27928,27929,45578,45579</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1900017$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10474189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kai, Masanori</creatorcontrib><creatorcontrib>Matsuoka, Masanori</creatorcontrib><creatorcontrib>Nakata, Noboru</creatorcontrib><creatorcontrib>Maeda, Shinji</creatorcontrib><creatorcontrib>Gidoh, Masaichi</creatorcontrib><creatorcontrib>Maeda, Yumi</creatorcontrib><creatorcontrib>Hashimoto, Ken</creatorcontrib><creatorcontrib>Kobayashi, Kazuo</creatorcontrib><creatorcontrib>Kashiwabara, Yoshiko</creatorcontrib><title>Diaminodiphenylsulfone resistance of Mycobacterium leprae due to mutations in the dihydropteroate synthase gene</title><title>FEMS microbiology letters</title><addtitle>FEMS Microbiol Lett</addtitle><description>Abstract
The nucleotide sequence analysis of the dihydropteroate synthase (DHPS) gene of six diaminodiphenylsulfone-resistant Mycobacterium leprae strains revealed that the mutation was limited at highly conserved amino acid residues 53 or 55. Though the mutation at amino acid residue 55 or its homologous site has been reported in other bacteria, the mutation at residue 53 is the first case in bacteria. This is the first paper which links the mutations in DHPS and sulfonamide resistance in M. leprae. This finding is medically and socially relevant, since leprosy is still a big problem in certain regions.</description><subject>Amino acids</subject><subject>Bacteria</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Chemotherapy</subject><subject>Dapsone - pharmacology</subject><subject>Diaminodiphenylsulfone</subject><subject>Dihydropteroate synthase</subject><subject>Dihydropteroate Synthase - genetics</subject><subject>Drug resistance</subject><subject>Drug Resistance, Microbial - genetics</subject><subject>Folic Acid Antagonists - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes, Bacterial</subject><subject>Genetic mutation</subject><subject>Genetics</subject><subject>Homology</subject><subject>Leprostatic Agents - pharmacology</subject><subject>Leprosy</subject><subject>Leprosy - microbiology</subject><subject>Microbiology</subject><subject>Molecular Sequence Data</subject><subject>Mutation</subject><subject>Mycobacterium leprae</subject><subject>Mycobacterium leprae - drug effects</subject><subject>Mycobacterium leprae - enzymology</subject><subject>Mycobacterium leprae - genetics</subject><subject>Nucleotide sequence</subject><subject>Nucleotides</subject><subject>Sulfonamides</subject><issn>0378-1097</issn><issn>1574-6968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqVkUGL1DAYhoMo7rj6FySoeGtNmqZpPAiyuirM4kXPIU2_OhnapCYpbv-9GTqoiCLmEkie90teHoSeUFLSvF4cS8pFXTSyaUsqpSxTR5lgory9g3Y_ru6iHWGiLSiR4gI9iPFICKkr0txHF5TUoqat3CH_xurJOt_b-QBuHeMyDt4BDhBtTNoZwH7AN6vxnTYJgl0mPMIcNOB-AZw8npakk_UuYutwOuRze1j74OdMe50Ax9Wlg46Av4CDh-jeoMcIj877Jfp8_fbT1fti__Hdh6vX-8LUrKEFB902A--1gU5oqXsjhWEVpWAoJ4ISTngr2obwjlUVgZpQ6Fkr6mowbddxdomeb3Pn4L8uEJOabDQwjtqBX6IShFDS8PafIBVVI2tWZfDpb-DRL8HlEqpilArOGWeZerlRJvgYAwxqDnbSYVWUqJM9dVQnReqkSJ3sqbM9dZvDj89PLN0E_S_RTVcGnp0BHY0eh5AF2fiTk1kxFRl7tWHf7Ajrf_xAXd_sc5k8gG8D_DL_JV78qcB3-QHIMw</recordid><startdate>19990815</startdate><enddate>19990815</enddate><creator>Kai, Masanori</creator><creator>Matsuoka, Masanori</creator><creator>Nakata, Noboru</creator><creator>Maeda, Shinji</creator><creator>Gidoh, Masaichi</creator><creator>Maeda, Yumi</creator><creator>Hashimoto, Ken</creator><creator>Kobayashi, Kazuo</creator><creator>Kashiwabara, Yoshiko</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19990815</creationdate><title>Diaminodiphenylsulfone resistance of Mycobacterium leprae due to mutations in the dihydropteroate synthase gene</title><author>Kai, Masanori ; Matsuoka, Masanori ; Nakata, Noboru ; Maeda, Shinji ; Gidoh, Masaichi ; Maeda, Yumi ; Hashimoto, Ken ; Kobayashi, Kazuo ; Kashiwabara, Yoshiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4361-5ea86f5daceb7a9adc97c3211ec150710505878605b3220e401ed38742fc8bb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Amino acids</topic><topic>Bacteria</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Chemotherapy</topic><topic>Dapsone - pharmacology</topic><topic>Diaminodiphenylsulfone</topic><topic>Dihydropteroate synthase</topic><topic>Dihydropteroate Synthase - genetics</topic><topic>Drug resistance</topic><topic>Drug Resistance, Microbial - genetics</topic><topic>Folic Acid Antagonists - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes, Bacterial</topic><topic>Genetic mutation</topic><topic>Genetics</topic><topic>Homology</topic><topic>Leprostatic Agents - pharmacology</topic><topic>Leprosy</topic><topic>Leprosy - microbiology</topic><topic>Microbiology</topic><topic>Molecular Sequence Data</topic><topic>Mutation</topic><topic>Mycobacterium leprae</topic><topic>Mycobacterium leprae - drug effects</topic><topic>Mycobacterium leprae - enzymology</topic><topic>Mycobacterium leprae - genetics</topic><topic>Nucleotide sequence</topic><topic>Nucleotides</topic><topic>Sulfonamides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kai, Masanori</creatorcontrib><creatorcontrib>Matsuoka, Masanori</creatorcontrib><creatorcontrib>Nakata, Noboru</creatorcontrib><creatorcontrib>Maeda, Shinji</creatorcontrib><creatorcontrib>Gidoh, Masaichi</creatorcontrib><creatorcontrib>Maeda, Yumi</creatorcontrib><creatorcontrib>Hashimoto, Ken</creatorcontrib><creatorcontrib>Kobayashi, Kazuo</creatorcontrib><creatorcontrib>Kashiwabara, Yoshiko</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEMS microbiology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kai, Masanori</au><au>Matsuoka, Masanori</au><au>Nakata, Noboru</au><au>Maeda, Shinji</au><au>Gidoh, Masaichi</au><au>Maeda, Yumi</au><au>Hashimoto, Ken</au><au>Kobayashi, Kazuo</au><au>Kashiwabara, Yoshiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diaminodiphenylsulfone resistance of Mycobacterium leprae due to mutations in the dihydropteroate synthase gene</atitle><jtitle>FEMS microbiology letters</jtitle><addtitle>FEMS Microbiol Lett</addtitle><date>1999-08-15</date><risdate>1999</risdate><volume>177</volume><issue>2</issue><spage>231</spage><epage>235</epage><pages>231-235</pages><issn>0378-1097</issn><eissn>1574-6968</eissn><coden>FMLED7</coden><abstract>Abstract
The nucleotide sequence analysis of the dihydropteroate synthase (DHPS) gene of six diaminodiphenylsulfone-resistant Mycobacterium leprae strains revealed that the mutation was limited at highly conserved amino acid residues 53 or 55. Though the mutation at amino acid residue 55 or its homologous site has been reported in other bacteria, the mutation at residue 53 is the first case in bacteria. This is the first paper which links the mutations in DHPS and sulfonamide resistance in M. leprae. This finding is medically and socially relevant, since leprosy is still a big problem in certain regions.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>10474189</pmid><doi>10.1111/j.1574-6968.1999.tb13737.x</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | FEMS microbiology letters, 1999-08, Vol.177 (2), p.231-235 |
| issn | 0378-1097 1574-6968 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Amino acids Bacteria Bacteriology Biological and medical sciences Chemotherapy Dapsone - pharmacology Diaminodiphenylsulfone Dihydropteroate synthase Dihydropteroate Synthase - genetics Drug resistance Drug Resistance, Microbial - genetics Folic Acid Antagonists - pharmacology Fundamental and applied biological sciences. Psychology Genes, Bacterial Genetic mutation Genetics Homology Leprostatic Agents - pharmacology Leprosy Leprosy - microbiology Microbiology Molecular Sequence Data Mutation Mycobacterium leprae Mycobacterium leprae - drug effects Mycobacterium leprae - enzymology Mycobacterium leprae - genetics Nucleotide sequence Nucleotides Sulfonamides |
| title | Diaminodiphenylsulfone resistance of Mycobacterium leprae due to mutations in the dihydropteroate synthase gene |
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