Dissociation of the eukaryotic initiation factor-4E/4E-BP1 complex involves phosphorylation of 4E-BP1 by an mTOR-associated kinase
mTOR immunoprecipitates contain two 4E-BP1 protein kinase activities. One appears to be due to mTOR itself and results in the phosphorylation of 4E-BP1 on residues T 36 and T 45, as shown previously by others. The other is a kinase which can be separated from mTOR and which phosphorylates 4E-BP1 wit...
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| Veröffentlicht in: | FEBS letters 1999-09, Vol.457 (3), p.489-493 |
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| creator | Heesom, Kate J Denton, Richard M |
| description | mTOR immunoprecipitates contain two 4E-BP1 protein kinase activities. One appears to be due to mTOR itself and results in the phosphorylation of 4E-BP1 on residues T
36 and T
45, as shown previously by others. The other is a kinase which can be separated from mTOR and which phosphorylates 4E-BP1 within a peptide(s) containing residues S
64 and T
69. This phosphorylation, which occurs predominantly on S
64, results in the dissociation of 4E-BP1 from eIF-4E. |
| doi_str_mv | 10.1016/S0014-5793(99)01094-7 |
| format | Article |
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64 and T
69. This phosphorylation, which occurs predominantly on S
64, results in the dissociation of 4E-BP1 from eIF-4E.</description><subject>4E-BP1</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Carrier Proteins</subject><subject>Eukaryotic Initiation Factor-4E</subject><subject>Insulin</subject><subject>Male</subject><subject>Molecular Sequence Data</subject><subject>mRNA translation initiation</subject><subject>mTOR</subject><subject>Peptide Initiation Factors - genetics</subject><subject>Peptide Initiation Factors - immunology</subject><subject>Peptide Initiation Factors - metabolism</subject><subject>Phosphoproteins - genetics</subject><subject>Phosphoproteins - immunology</subject><subject>Phosphoproteins - metabolism</subject><subject>Phosphorylation</subject><subject>Phosphotransferases (Alcohol Group Acceptor) - isolation & purification</subject><subject>Phosphotransferases (Alcohol Group Acceptor) - metabolism</subject><subject>Precipitin Tests</subject><subject>Protein Kinases - immunology</subject><subject>Protein Kinases - isolation & purification</subject><subject>Protein Kinases - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Recombinant Proteins - genetics</subject><subject>Recombinant Proteins - metabolism</subject><subject>TOR Serine-Threonine Kinases</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE9P2zAYh60JNDq2jzDkExoHg107iX2aBpQVCanTgLPlOG-ERxIXOy30uk8-t4kQN3aw_Od93t9rPQh9ZfSUUZaf3VLKBMkKxb8pdUIZVYIUH9CEyYITLnK5hyavyAH6FOMfmu6SqY_ogFFRMMmzCfp76WL01pne-Q77GvcPgGH1aMLG985i17l-LNbG9j4QMTsTM3L-i2Hr22UDL4lZ-2YNES8ffEwrbJrXuBEtN9h0uL1b_CZmnAcVfnSdifAZ7demifBl3A_R_dXs7mJObhY_ry9-3BCbCVGQUkqWZWU5lVCWdaaA88oqa3KqcshBSgu8ojxXxjIpaJ1TIeWUinSop8YofoiOh9xl8E8riL1uXbTQNKYDv4q6SHqoyEUCswG0wccYoNbL4NpkRDOqt_L1Tr7emtVK6Z18XaS-o3HAqmyhetM12E7AfACeXQOb_0vVV7Pz6a6yLSi1e97O-j5EQTK2dhB0tA46C5ULYHtdeffOb_8B1emoVw</recordid><startdate>19990903</startdate><enddate>19990903</enddate><creator>Heesom, Kate J</creator><creator>Denton, Richard M</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990903</creationdate><title>Dissociation of the eukaryotic initiation factor-4E/4E-BP1 complex involves phosphorylation of 4E-BP1 by an mTOR-associated kinase</title><author>Heesom, Kate J ; 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One appears to be due to mTOR itself and results in the phosphorylation of 4E-BP1 on residues T
36 and T
45, as shown previously by others. The other is a kinase which can be separated from mTOR and which phosphorylates 4E-BP1 within a peptide(s) containing residues S
64 and T
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| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 1999-09, Vol.457 (3), p.489-493 |
| issn | 0014-5793 1873-3468 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elsevier ScienceDirect Journals; Wiley Online Library Free Content; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | 4E-BP1 Amino Acid Sequence Animals Carrier Proteins Eukaryotic Initiation Factor-4E Insulin Male Molecular Sequence Data mRNA translation initiation mTOR Peptide Initiation Factors - genetics Peptide Initiation Factors - immunology Peptide Initiation Factors - metabolism Phosphoproteins - genetics Phosphoproteins - immunology Phosphoproteins - metabolism Phosphorylation Phosphotransferases (Alcohol Group Acceptor) - isolation & purification Phosphotransferases (Alcohol Group Acceptor) - metabolism Precipitin Tests Protein Kinases - immunology Protein Kinases - isolation & purification Protein Kinases - metabolism Rats Rats, Wistar Recombinant Proteins - genetics Recombinant Proteins - metabolism TOR Serine-Threonine Kinases |
| title | Dissociation of the eukaryotic initiation factor-4E/4E-BP1 complex involves phosphorylation of 4E-BP1 by an mTOR-associated kinase |
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