Engineering DNA vaccines via co-delivery of co-stimulatory molecule genes
DNA immunization has been investigated as a potential immunization strategy against infectious diseases and cancer. To enhance a DNA vaccine's ability to induce CTL response in vivo, we co-administered CD80 and CD86 expression cassettes along with HIV-1 immunogens. This manipulation resulted in...
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| Veröffentlicht in: | Vaccine 1998-11, Vol.16 (19), p.1828-1835 |
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| container_title | Vaccine |
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| creator | Kim, Jong J. Nottingham, Liesl K. Wilson, Darren M. Bagarazzi, Mark L. Tsai, Anthony Morrison, Lake D. Javadian, Ali Chalian, Ara A. Agadjanyan, Michael G. Weiner, David B. |
| description | DNA immunization has been investigated as a potential immunization strategy against infectious diseases and cancer. To enhance a DNA vaccine's ability to induce CTL response
in vivo, we co-administered CD80 and CD86 expression cassettes along with HIV-1 immunogens. This manipulation resulted in a dramatic increase in MHC class I-restricted and CD8+ T-cell-dependent CTL responses in both mice and chimpanzees. This strategy of engineering vaccine producing cells to be more efficient T-cell activators could be an important tool for optimizing antigen-specific T-cell-mediated immune responses in the pursuit of more rationally designed vaccines and immune therapies. |
| doi_str_mv | 10.1016/S0264-410X(98)00177-7 |
| format | Article |
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in vivo, we co-administered CD80 and CD86 expression cassettes along with HIV-1 immunogens. This manipulation resulted in a dramatic increase in MHC class I-restricted and CD8+ T-cell-dependent CTL responses in both mice and chimpanzees. This strategy of engineering vaccine producing cells to be more efficient T-cell activators could be an important tool for optimizing antigen-specific T-cell-mediated immune responses in the pursuit of more rationally designed vaccines and immune therapies.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/S0264-410X(98)00177-7</identifier><identifier>PMID: 9795388</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>AIDS/HIV ; AIDS/HIV-1 ; Amino Acid Sequence ; Animals ; Antigen Presentation ; Antigens, CD - biosynthesis ; Antigens, CD - genetics ; Antigens, CD - immunology ; B7-1 Antigen - biosynthesis ; B7-1 Antigen - genetics ; B7-1 Antigen - immunology ; B7-2 Antigen ; Biological and medical sciences ; CD8-Positive T-Lymphocytes - immunology ; CD80 ; CD86 ; Cloning, Molecular ; co-stimulatory molecules ; CTL ; DNA vaccination ; DNA, Complementary - administration & dosage ; DNA, Complementary - genetics ; DNA, Complementary - metabolism ; Epitopes - immunology ; Fundamental and applied biological sciences. Psychology ; Histocompatibility Antigens Class I - immunology ; HIV Antigens - genetics ; HIV Antigens - immunology ; HIV-1 - immunology ; immune responses ; Lymphocyte Activation - immunology ; Lymphokines - biosynthesis ; Membrane Glycoproteins - biosynthesis ; Membrane Glycoproteins - genetics ; Membrane Glycoproteins - immunology ; Mice ; Mice, Inbred BALB C ; Microbiology ; Molecular Sequence Data ; Pan troglodytes ; T-Lymphocytes, Cytotoxic - immunology ; T-Lymphocytes, Helper-Inducer - immunology ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies ; Vaccines, DNA - genetics ; Vaccines, DNA - immunology ; Virology</subject><ispartof>Vaccine, 1998-11, Vol.16 (19), p.1828-1835</ispartof><rights>1998</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-52636ef53d9f4149c1fa6092683eee81d385f0276587a27a267ba0f17263d70d3</citedby><cites>FETCH-LOGICAL-c436t-52636ef53d9f4149c1fa6092683eee81d385f0276587a27a267ba0f17263d70d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X98001777$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1661742$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9795388$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Jong J.</creatorcontrib><creatorcontrib>Nottingham, Liesl K.</creatorcontrib><creatorcontrib>Wilson, Darren M.</creatorcontrib><creatorcontrib>Bagarazzi, Mark L.</creatorcontrib><creatorcontrib>Tsai, Anthony</creatorcontrib><creatorcontrib>Morrison, Lake D.</creatorcontrib><creatorcontrib>Javadian, Ali</creatorcontrib><creatorcontrib>Chalian, Ara A.</creatorcontrib><creatorcontrib>Agadjanyan, Michael G.</creatorcontrib><creatorcontrib>Weiner, David B.</creatorcontrib><title>Engineering DNA vaccines via co-delivery of co-stimulatory molecule genes</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>DNA immunization has been investigated as a potential immunization strategy against infectious diseases and cancer. To enhance a DNA vaccine's ability to induce CTL response
in vivo, we co-administered CD80 and CD86 expression cassettes along with HIV-1 immunogens. This manipulation resulted in a dramatic increase in MHC class I-restricted and CD8+ T-cell-dependent CTL responses in both mice and chimpanzees. This strategy of engineering vaccine producing cells to be more efficient T-cell activators could be an important tool for optimizing antigen-specific T-cell-mediated immune responses in the pursuit of more rationally designed vaccines and immune therapies.</description><subject>AIDS/HIV</subject><subject>AIDS/HIV-1</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Antigen Presentation</subject><subject>Antigens, CD - biosynthesis</subject><subject>Antigens, CD - genetics</subject><subject>Antigens, CD - immunology</subject><subject>B7-1 Antigen - biosynthesis</subject><subject>B7-1 Antigen - genetics</subject><subject>B7-1 Antigen - immunology</subject><subject>B7-2 Antigen</subject><subject>Biological and medical sciences</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>CD80</subject><subject>CD86</subject><subject>Cloning, Molecular</subject><subject>co-stimulatory molecules</subject><subject>CTL</subject><subject>DNA vaccination</subject><subject>DNA, Complementary - administration & dosage</subject><subject>DNA, Complementary - genetics</subject><subject>DNA, Complementary - metabolism</subject><subject>Epitopes - immunology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Histocompatibility Antigens Class I - immunology</subject><subject>HIV Antigens - genetics</subject><subject>HIV Antigens - immunology</subject><subject>HIV-1 - immunology</subject><subject>immune responses</subject><subject>Lymphocyte Activation - immunology</subject><subject>Lymphokines - biosynthesis</subject><subject>Membrane Glycoproteins - biosynthesis</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Membrane Glycoproteins - immunology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microbiology</subject><subject>Molecular Sequence Data</subject><subject>Pan troglodytes</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><subject>T-Lymphocytes, Helper-Inducer - immunology</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><subject>Vaccines, DNA - genetics</subject><subject>Vaccines, DNA - immunology</subject><subject>Virology</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKxDAUhoMoOl4eQehCRBfVpGlzWckw3gZEFyq4CzE5GSK9aNIW5u3NOIMuhUDIOd9_knwIHRN8QTBhl8-4YGVeEvx2JsU5xoTznG-hCRGc5kVFxDaa_CJ7aD_GD4xxRYncRbuSy4oKMUHzm3bhW4Dg20V2_TjNRm1MKsRs9DozXW6h9iOEZda51TH2vhlq3Xep0nQ1mKGGbAEpcIh2nK4jHG32A_R6e_Myu88fnu7ms-lDbkrK-rwqGGXgKmqlK0kpDXGaYVkwQQFAEEtF5XDBWSW4LtJi_F1jR3jKWY4tPUCn67mfofsaIPaq8dFAXesWuiEqnn4paUETWK1BE7oYAzj1GXyjw1IRrFYK1Y9CtfKjpFA_ChVPuePNBcN7A_Y3tXGW-iebvo5G1y7o1vj4N5wxwssiYVdrDJKM0UNQ0XhoDVgfwPTKdv6fh3wDmSSMdg</recordid><startdate>19981101</startdate><enddate>19981101</enddate><creator>Kim, Jong J.</creator><creator>Nottingham, Liesl K.</creator><creator>Wilson, Darren M.</creator><creator>Bagarazzi, Mark L.</creator><creator>Tsai, Anthony</creator><creator>Morrison, Lake D.</creator><creator>Javadian, Ali</creator><creator>Chalian, Ara A.</creator><creator>Agadjanyan, Michael G.</creator><creator>Weiner, David B.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19981101</creationdate><title>Engineering DNA vaccines via co-delivery of co-stimulatory molecule genes</title><author>Kim, Jong J. ; Nottingham, Liesl K. ; Wilson, Darren M. ; Bagarazzi, Mark L. ; Tsai, Anthony ; Morrison, Lake D. ; Javadian, Ali ; Chalian, Ara A. ; Agadjanyan, Michael G. ; Weiner, David B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-52636ef53d9f4149c1fa6092683eee81d385f0276587a27a267ba0f17263d70d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>AIDS/HIV</topic><topic>AIDS/HIV-1</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Antigen Presentation</topic><topic>Antigens, CD - biosynthesis</topic><topic>Antigens, CD - genetics</topic><topic>Antigens, CD - immunology</topic><topic>B7-1 Antigen - biosynthesis</topic><topic>B7-1 Antigen - genetics</topic><topic>B7-1 Antigen - immunology</topic><topic>B7-2 Antigen</topic><topic>Biological and medical sciences</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>CD80</topic><topic>CD86</topic><topic>Cloning, Molecular</topic><topic>co-stimulatory molecules</topic><topic>CTL</topic><topic>DNA vaccination</topic><topic>DNA, Complementary - administration & dosage</topic><topic>DNA, Complementary - genetics</topic><topic>DNA, Complementary - metabolism</topic><topic>Epitopes - immunology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Histocompatibility Antigens Class I - immunology</topic><topic>HIV Antigens - genetics</topic><topic>HIV Antigens - immunology</topic><topic>HIV-1 - immunology</topic><topic>immune responses</topic><topic>Lymphocyte Activation - immunology</topic><topic>Lymphokines - biosynthesis</topic><topic>Membrane Glycoproteins - biosynthesis</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Membrane Glycoproteins - immunology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Microbiology</topic><topic>Molecular Sequence Data</topic><topic>Pan troglodytes</topic><topic>T-Lymphocytes, Cytotoxic - immunology</topic><topic>T-Lymphocytes, Helper-Inducer - immunology</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><topic>Vaccines, DNA - genetics</topic><topic>Vaccines, DNA - immunology</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Jong J.</creatorcontrib><creatorcontrib>Nottingham, Liesl K.</creatorcontrib><creatorcontrib>Wilson, Darren M.</creatorcontrib><creatorcontrib>Bagarazzi, Mark L.</creatorcontrib><creatorcontrib>Tsai, Anthony</creatorcontrib><creatorcontrib>Morrison, Lake D.</creatorcontrib><creatorcontrib>Javadian, Ali</creatorcontrib><creatorcontrib>Chalian, Ara A.</creatorcontrib><creatorcontrib>Agadjanyan, Michael G.</creatorcontrib><creatorcontrib>Weiner, David B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Jong J.</au><au>Nottingham, Liesl K.</au><au>Wilson, Darren M.</au><au>Bagarazzi, Mark L.</au><au>Tsai, Anthony</au><au>Morrison, Lake D.</au><au>Javadian, Ali</au><au>Chalian, Ara A.</au><au>Agadjanyan, Michael G.</au><au>Weiner, David B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Engineering DNA vaccines via co-delivery of co-stimulatory molecule genes</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>1998-11-01</date><risdate>1998</risdate><volume>16</volume><issue>19</issue><spage>1828</spage><epage>1835</epage><pages>1828-1835</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>DNA immunization has been investigated as a potential immunization strategy against infectious diseases and cancer. To enhance a DNA vaccine's ability to induce CTL response
in vivo, we co-administered CD80 and CD86 expression cassettes along with HIV-1 immunogens. This manipulation resulted in a dramatic increase in MHC class I-restricted and CD8+ T-cell-dependent CTL responses in both mice and chimpanzees. This strategy of engineering vaccine producing cells to be more efficient T-cell activators could be an important tool for optimizing antigen-specific T-cell-mediated immune responses in the pursuit of more rationally designed vaccines and immune therapies.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>9795388</pmid><doi>10.1016/S0264-410X(98)00177-7</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 1998-11, Vol.16 (19), p.1828-1835 |
| issn | 0264-410X 1873-2518 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | AIDS/HIV AIDS/HIV-1 Amino Acid Sequence Animals Antigen Presentation Antigens, CD - biosynthesis Antigens, CD - genetics Antigens, CD - immunology B7-1 Antigen - biosynthesis B7-1 Antigen - genetics B7-1 Antigen - immunology B7-2 Antigen Biological and medical sciences CD8-Positive T-Lymphocytes - immunology CD80 CD86 Cloning, Molecular co-stimulatory molecules CTL DNA vaccination DNA, Complementary - administration & dosage DNA, Complementary - genetics DNA, Complementary - metabolism Epitopes - immunology Fundamental and applied biological sciences. Psychology Histocompatibility Antigens Class I - immunology HIV Antigens - genetics HIV Antigens - immunology HIV-1 - immunology immune responses Lymphocyte Activation - immunology Lymphokines - biosynthesis Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - genetics Membrane Glycoproteins - immunology Mice Mice, Inbred BALB C Microbiology Molecular Sequence Data Pan troglodytes T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Helper-Inducer - immunology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, DNA - genetics Vaccines, DNA - immunology Virology |
| title | Engineering DNA vaccines via co-delivery of co-stimulatory molecule genes |
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