Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus

ERK5 (also known as BMK1), a member of the mitogen-activated protein kinase (MAPK) superfamily, was known to be activated strongly by oxidant and osmotic stresses. Here we have found that ERK5 is strongly activated by epidermal growth factor and nerve growth factor, whose receptors are tyrosine kina...

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Veröffentlicht in:	The Journal of biological chemistry 1999-09, Vol.274 (37), p.26563-26571
Hauptverfasser:	Kamakura, S, Moriguchi, T, Nishida, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence BMK1 protein c-fos gene Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors Calcium-Calmodulin-Dependent Protein Kinases - chemistry Calcium-Calmodulin-Dependent Protein Kinases - genetics Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cell Membrane - metabolism Cell Nucleus - enzymology Cell Nucleus - metabolism CL100 protein Cloning, Molecular DNA Primers DNA, Complementary Enzyme Activation Enzyme Inhibitors - pharmacology epidermal growth factor ERK5 protein GTP Phosphohydrolases - metabolism Humans MAP kinase MAPK kinase MEK5 protein Mice Mitogen-Activated Protein Kinase 7 Mitogen-Activated Protein Kinases MKP-3 protein Molecular Sequence Data nerve growth factor PD98059 Receptor Protein-Tyrosine Kinases - antagonists & inhibitors Receptor Protein-Tyrosine Kinases - metabolism Sap-1a protein Sequence Homology, Amino Acid Signal Transduction U0126
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