Preclinical studies on a recombinant group B meningococcal porin as a carrier for a novel Haemophilus influenzae type b conjugate vaccine

In anticipation of future combination vaccines, a recombinant class 3 porin (rPorB) of group B meningococci was evaluated as an alternative carrier protein for a Haemophilus influenzae type b (Hib) polyribosylribotol phosphate (PRP) conjugate vaccine. The use of rPorB may avoid undesirable immunolog...

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Veröffentlicht in:	Vaccine 1998-11, Vol.16 (19), p.1842-1849
Hauptverfasser:	Fusco, Peter C., Michon, Francis, Laude-Sharp, Maryline, Minetti, Conceição A.S.A., Huang, Chun-Hsien, Heron, Iver, Blake, M.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral - biosynthesis Antibodies, Viral - blood Bacterial Capsules Bacterial Outer Membrane Proteins - immunology Bacteriology Biological and medical sciences conjugate Enzyme-Linked Immunosorbent Assay Female Fundamental and applied biological sciences. Psychology Haemophilus influenzae Haemophilus Vaccines - immunology Haemophilus Vaccines - pharmacology Immunoglobulin G - biosynthesis Immunoglobulin G - blood Mice Mice, Inbred Strains Microbiology Neisseria meningitidis - immunology Polysaccharides, Bacterial - immunology porin Porins Rats Rats, Sprague-Dawley Recombinant Proteins - biosynthesis Recombinant Proteins - genetics Recombinant Proteins - immunology Tetanus Toxoid - pharmacology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, Conjugate - pharmacology
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