Receptor-mediated activation of phospholipase D by sphingosine 1-phosphate in skeletal muscle C2C12 cells: A role for protein kinase C

The present study showed that sphingosine 1-phosphate (SPP) induced rapid stimulation of phospholipase D (PLD) in skeletal muscle C2C12 cells. The effect was receptor-mediated since it was fully inhibited by pertussis toxin. All known SPP-specific receptors, Edg-1, Edg-3 and AGR16/H218, resulted to...

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Veröffentlicht in:	FEBS letters 1999-08, Vol.457 (2), p.184-188
Hauptverfasser:	Meacci, Elisabetta, Vasta, Valeria, Donati, Chiara, Farnararo, Marta, Bruni, Paola
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals C2C12 myoblast Cells, Cultured Edg receptor Enzyme Activation GTP-Binding Proteins - physiology Isoenzymes - metabolism Lysophospholipids Mice Muscle, Skeletal - cytology Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Pertussis Toxin Phospholipase D Phospholipase D - metabolism Protein kinase C Protein Kinase C - metabolism Sphingosine - analogs & derivatives Sphingosine - pharmacology Sphingosine 1-phosphate Subcellular Fractions Virulence Factors, Bordetella - pharmacology
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