Retroviruses as Model Systems for the Study of Nuclear RNA Export Pathways
Retroviral replication requires the nuclear export and cytoplasmic translation of both incompletely spliced and fully spliced forms of the initial, genome length viral transcript. Thus in most simple retroviruses, this initial transcript leaves the nucleus as both an unspliced mRNA encoding Gag and...
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| Veröffentlicht in: | Virology 1998-09, Vol.249 (2), p.203-210 |
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| creator | Cullen, Bryan R. |
| description | Retroviral replication requires the nuclear export and cytoplasmic translation of both incompletely spliced and fully spliced forms of the initial, genome length viral transcript. Thus in most simple retroviruses, this initial transcript leaves the nucleus as both an unspliced mRNA encoding Gag and Gag-Pol and as a singly spliced mRNA encoding Env. More complex retroviruses derive a range of unspliced, incompletely spliced and multiply spliced mRNAs from their single initial RNA transcript. For example, human immunodeficiency virus type 1 (HIV-1), which remains the most complex retrovirus known, encodes 1 unspliced similar to 9-kb RNA encoding Gag and Gag-Pol, 5 singly spliced, similar to 4-kb mRNAs encoding Vif, Vpr, Vpu, and Env, and finally similar to 16 multiply spliced similar to 2-kb mRNAs encoding Tat, Rev, and Nef. |
| doi_str_mv | 10.1006/viro.1998.9331 |
| format | Article |
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| ispartof | Virology, 1998-09, Vol.249 (2), p.203-210 |
| issn | 0042-6822 1096-0341 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Amino Acid Sequence Animals Base Sequence Biological Transport, Active Carrier Proteins - metabolism Cell Nucleus - metabolism Cell Nucleus - virology Exportin 1 Protein Gene Products, rev - genetics Gene Products, rev - metabolism Genes, rev HIV-1 - genetics HIV-1 - physiology Human immunodeficiency virus 1 Humans Karyopherins Models, Biological Molecular Sequence Data Nuclear Proteins - metabolism Nucleic Acid Conformation Receptors, Cytoplasmic and Nuclear Retroviridae - genetics Retroviridae - physiology rev Gene Products, Human Immunodeficiency Virus RNA Splicing RNA, Viral - chemistry RNA, Viral - genetics RNA, Viral - metabolism Virus Replication |
| title | Retroviruses as Model Systems for the Study of Nuclear RNA Export Pathways |
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