Causes and consequences of acidic pH in tumors: a magnetic resonance study

A consequence of metabolism in any tissue is the formation of hydrogen ions, which are actively transported out of the cell. However, although most solid tumors maintain their intracellular pH (pHi) within a narrow range to provide a favorable environment for various intracellular activities, their...

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Veröffentlicht in:	Advances in enzyme regulation 1999-01, Vol.39 (1), p.13-30
Hauptverfasser:	Stubbs, M, McSheehy, P M, Griffiths, J R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Cell Membrane - metabolism Humans Hydrogen-Ion Concentration Lactic Acid - metabolism Magnetic Resonance Spectroscopy Mice Mice, Nude Models, Biological Neoplasms - metabolism Neoplasms, Experimental - metabolism Nucleotides - metabolism Rats
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