Targeted Integration of Adeno-Associated Virus-Derived Plasmids in Transfected Human Cells

Adeno-associated virus (AAV) integrates its genomic DNA into a defined region of human chromosome 19 (AAVS1). The specificity of integration is dependent on the presence of the inverted terminal repeats (ITR) and on expression of therepgene. To develop vectors capable of targeting the insertion of a...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 1998-09, Vol.249 (2), p.249-259
Hauptverfasser:	Pieroni, Luisa, Fipaldini, Cristina, Monciotti, Andrea, Cimini, Daniela, Sgura, Antonella, Fattori, Elena, Epifano, Olga, Cortese, Riccardo, Palombo, Fabio, La Monica, Nicola
Format:	Artikel
Sprache:	eng
Schlagworte:	Adeno-associated virus Base Sequence Cell Line Chromosomes, Human, Pair 19 - genetics Chromosomes, Human, Pair 19 - virology Dependovirus - genetics DNA Primers - genetics DNA, Viral - genetics Genetic Vectors HeLa Cells Humans In Situ Hybridization, Fluorescence Plasmids - genetics Polymerase Chain Reaction Transfection Virus Integration - genetics
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