Sympathetic and Sensory Innervations Are Heterogeneously Distributed in Relation to the Blood Vessels at the Extensor carpi radialis brevis Muscle Origin of Man
By using immunohistochemistry and antibodies to a general nerve marker, protein gene product (PGP) 9.5, the overall innervation at the extensor carpi radialis brevis (ECRB) muscle origin was investigated in patients with tennis elbow and in healthy controls. The autonomic innervation was studied by...
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| Veröffentlicht in: | Cells, tissues, organs tissues, organs, 1999-01, Vol.165 (1), p.45-54 |
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| creator | Ljung, Björn-Ove Forsgren, Sture Fridén, Jan |
| description | By using immunohistochemistry and antibodies to a general nerve marker, protein gene product (PGP) 9.5, the overall innervation at the extensor carpi radialis brevis (ECRB) muscle origin was investigated in patients with tennis elbow and in healthy controls. The autonomic innervation was studied by using antibodies to neuropeptide Y (NPY), tyrosine hydroxylase (TH), and vasoactive intestinal peptide (VIP). The sensory innervation was visualized by using antibodies to substance P and calcitonin gene-related peptide. PGP 9.5 immunoreactions were detected in association with small blood vessels and arteries and within nerve bundles. There was, however, heterogeneity in the perivascular nerve fiber distribution since some blood vessels exhibited a high degree of PGP 9.5 innervation and some negligible or no such innervation at all. There was marked TH/NPY innervation in the walls of a subpopulation of the arteries, basically no VIP-containing nerves, and sensory innervation restricted to the small blood vessels. These observations show that the ECRB muscle origin is supplied with heterogeneously distributed sympathetic and sensory innervations and, furthermore, that there appears to be an imbalance between the vasoconstrictor and vasodilator innervations along the vascular tree in this region. |
| doi_str_mv | 10.1159/000016673 |
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The autonomic innervation was studied by using antibodies to neuropeptide Y (NPY), tyrosine hydroxylase (TH), and vasoactive intestinal peptide (VIP). The sensory innervation was visualized by using antibodies to substance P and calcitonin gene-related peptide. PGP 9.5 immunoreactions were detected in association with small blood vessels and arteries and within nerve bundles. There was, however, heterogeneity in the perivascular nerve fiber distribution since some blood vessels exhibited a high degree of PGP 9.5 innervation and some negligible or no such innervation at all. There was marked TH/NPY innervation in the walls of a subpopulation of the arteries, basically no VIP-containing nerves, and sensory innervation restricted to the small blood vessels. These observations show that the ECRB muscle origin is supplied with heterogeneously distributed sympathetic and sensory innervations and, furthermore, that there appears to be an imbalance between the vasoconstrictor and vasodilator innervations along the vascular tree in this region.</description><identifier>ISSN: 1422-6405</identifier><identifier>EISSN: 1422-6421</identifier><identifier>DOI: 10.1159/000016673</identifier><identifier>PMID: 10460973</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adult ; Antibodies ; Biopsy ; Calcitonin Gene-Related Peptide - analysis ; Calcitonin Gene-Related Peptide - immunology ; Elbow - blood supply ; Elbow - innervation ; Female ; Humans ; Male ; Middle Aged ; Muscle, Skeletal - blood supply ; Muscle, Skeletal - innervation ; Nerve Fibers - chemistry ; Nerve Fibers - enzymology ; Neurons, Afferent - pathology ; Neurons, Afferent - ultrastructure ; Neuropeptide Y - analysis ; Neuropeptide Y - immunology ; Original Paper ; Substance P - analysis ; Substance P - immunology ; Sympathetic Nervous System - anatomy & histology ; Sympathetic Nervous System - cytology ; Tendons - blood supply ; Tendons - innervation ; Tennis Elbow - pathology ; Thiolester Hydrolases - analysis ; Thiolester Hydrolases - immunology ; Tyrosine 3-Monooxygenase - analysis ; Tyrosine 3-Monooxygenase - immunology ; Ubiquitin Thiolesterase ; Vasoactive Intestinal Peptide - analysis ; Vasoactive Intestinal Peptide - immunology</subject><ispartof>Cells, tissues, organs, 1999-01, Vol.165 (1), p.45-54</ispartof><rights>1999 S. Karger AG, Basel</rights><rights>Copyright (c) 1999 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c270t-786a07eacb45f45517b104b75895025e2ac571d0abd5023c3a009a45053795f03</citedby><cites>FETCH-LOGICAL-c270t-786a07eacb45f45517b104b75895025e2ac571d0abd5023c3a009a45053795f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10460973$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ljung, Björn-Ove</creatorcontrib><creatorcontrib>Forsgren, Sture</creatorcontrib><creatorcontrib>Fridén, Jan</creatorcontrib><title>Sympathetic and Sensory Innervations Are Heterogeneously Distributed in Relation to the Blood Vessels at the Extensor carpi radialis brevis Muscle Origin of Man</title><title>Cells, tissues, organs</title><addtitle>Cells Tissues Organs</addtitle><description>By using immunohistochemistry and antibodies to a general nerve marker, protein gene product (PGP) 9.5, the overall innervation at the extensor carpi radialis brevis (ECRB) muscle origin was investigated in patients with tennis elbow and in healthy controls. The autonomic innervation was studied by using antibodies to neuropeptide Y (NPY), tyrosine hydroxylase (TH), and vasoactive intestinal peptide (VIP). The sensory innervation was visualized by using antibodies to substance P and calcitonin gene-related peptide. PGP 9.5 immunoreactions were detected in association with small blood vessels and arteries and within nerve bundles. There was, however, heterogeneity in the perivascular nerve fiber distribution since some blood vessels exhibited a high degree of PGP 9.5 innervation and some negligible or no such innervation at all. There was marked TH/NPY innervation in the walls of a subpopulation of the arteries, basically no VIP-containing nerves, and sensory innervation restricted to the small blood vessels. These observations show that the ECRB muscle origin is supplied with heterogeneously distributed sympathetic and sensory innervations and, furthermore, that there appears to be an imbalance between the vasoconstrictor and vasodilator innervations along the vascular tree in this region.</description><subject>Adult</subject><subject>Antibodies</subject><subject>Biopsy</subject><subject>Calcitonin Gene-Related Peptide - analysis</subject><subject>Calcitonin Gene-Related Peptide - immunology</subject><subject>Elbow - blood supply</subject><subject>Elbow - innervation</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle, Skeletal - blood supply</subject><subject>Muscle, Skeletal - innervation</subject><subject>Nerve Fibers - chemistry</subject><subject>Nerve Fibers - enzymology</subject><subject>Neurons, Afferent - pathology</subject><subject>Neurons, Afferent - ultrastructure</subject><subject>Neuropeptide Y - analysis</subject><subject>Neuropeptide Y - immunology</subject><subject>Original Paper</subject><subject>Substance P - analysis</subject><subject>Substance P - immunology</subject><subject>Sympathetic Nervous System - anatomy & histology</subject><subject>Sympathetic Nervous System - cytology</subject><subject>Tendons - blood supply</subject><subject>Tendons - innervation</subject><subject>Tennis Elbow - pathology</subject><subject>Thiolester Hydrolases - analysis</subject><subject>Thiolester Hydrolases - immunology</subject><subject>Tyrosine 3-Monooxygenase - analysis</subject><subject>Tyrosine 3-Monooxygenase - immunology</subject><subject>Ubiquitin Thiolesterase</subject><subject>Vasoactive Intestinal Peptide - analysis</subject><subject>Vasoactive Intestinal Peptide - immunology</subject><issn>1422-6405</issn><issn>1422-6421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkU1v1DAQhi0EoqXlwBkJjXpA4rCt7cRxcyxLoZVardQPrpHjTBYXr53aTsX-G34qbnZVEKovY88888ozLyHvGD1kTNRHNB9WVbJ4QXZZyfmsKjl7-XSnYoe8ifEuUzwXXpMdRsuK1rLYJb-v16tBpR-YjAblOrhGF31Yw7lzGB5UMt5FOAkIZ5gw-CU69GO0a_hiYgqmHRN2YBxcoZ1gSB6yHHy23nfwHWNEG0GlKXn6K03yoFUYDATVGWVNhDbgQw6XY9QWYRHMMiv6Hi6V2yevemUjvt3GPXL79fRmfja7WHw7n59czDSXNM3kcaWoRKXbUvSlEEy2echWiuNaUC6QKy0k66hqu_wudKEorVUpqChkLXpa7JGPG90h-PsRY2pWJmq0Vk0DNzJvryzpI3jwH3jnx-Dy3xrOecUZq-oMfdpAOvgYA_bNEMxKhXXDaPPoWfPkWWY_bAXHdoXdP-TGpAy83wA_VVhi-Ats2w-erc5vFhPQDF1f_AGlBaZ5</recordid><startdate>199901</startdate><enddate>199901</enddate><creator>Ljung, Björn-Ove</creator><creator>Forsgren, Sture</creator><creator>Fridén, Jan</creator><general>S. 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Forsgren, Sture ; Fridén, Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c270t-786a07eacb45f45517b104b75895025e2ac571d0abd5023c3a009a45053795f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Antibodies</topic><topic>Biopsy</topic><topic>Calcitonin Gene-Related Peptide - analysis</topic><topic>Calcitonin Gene-Related Peptide - immunology</topic><topic>Elbow - blood supply</topic><topic>Elbow - innervation</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle, Skeletal - blood supply</topic><topic>Muscle, Skeletal - innervation</topic><topic>Nerve Fibers - chemistry</topic><topic>Nerve Fibers - enzymology</topic><topic>Neurons, Afferent - pathology</topic><topic>Neurons, Afferent - ultrastructure</topic><topic>Neuropeptide Y - analysis</topic><topic>Neuropeptide Y - immunology</topic><topic>Original Paper</topic><topic>Substance P - analysis</topic><topic>Substance P - immunology</topic><topic>Sympathetic Nervous System - anatomy & histology</topic><topic>Sympathetic Nervous System - cytology</topic><topic>Tendons - blood supply</topic><topic>Tendons - innervation</topic><topic>Tennis Elbow - pathology</topic><topic>Thiolester Hydrolases - analysis</topic><topic>Thiolester Hydrolases - immunology</topic><topic>Tyrosine 3-Monooxygenase - analysis</topic><topic>Tyrosine 3-Monooxygenase - immunology</topic><topic>Ubiquitin Thiolesterase</topic><topic>Vasoactive Intestinal Peptide - analysis</topic><topic>Vasoactive Intestinal Peptide - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ljung, Björn-Ove</creatorcontrib><creatorcontrib>Forsgren, Sture</creatorcontrib><creatorcontrib>Fridén, Jan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Cells, tissues, organs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ljung, Björn-Ove</au><au>Forsgren, Sture</au><au>Fridén, Jan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sympathetic and Sensory Innervations Are Heterogeneously Distributed in Relation to the Blood Vessels at the Extensor carpi radialis brevis Muscle Origin of Man</atitle><jtitle>Cells, tissues, organs</jtitle><addtitle>Cells Tissues Organs</addtitle><date>1999-01</date><risdate>1999</risdate><volume>165</volume><issue>1</issue><spage>45</spage><epage>54</epage><pages>45-54</pages><issn>1422-6405</issn><eissn>1422-6421</eissn><abstract>By using immunohistochemistry and antibodies to a general nerve marker, protein gene product (PGP) 9.5, the overall innervation at the extensor carpi radialis brevis (ECRB) muscle origin was investigated in patients with tennis elbow and in healthy controls. The autonomic innervation was studied by using antibodies to neuropeptide Y (NPY), tyrosine hydroxylase (TH), and vasoactive intestinal peptide (VIP). The sensory innervation was visualized by using antibodies to substance P and calcitonin gene-related peptide. PGP 9.5 immunoreactions were detected in association with small blood vessels and arteries and within nerve bundles. There was, however, heterogeneity in the perivascular nerve fiber distribution since some blood vessels exhibited a high degree of PGP 9.5 innervation and some negligible or no such innervation at all. There was marked TH/NPY innervation in the walls of a subpopulation of the arteries, basically no VIP-containing nerves, and sensory innervation restricted to the small blood vessels. These observations show that the ECRB muscle origin is supplied with heterogeneously distributed sympathetic and sensory innervations and, furthermore, that there appears to be an imbalance between the vasoconstrictor and vasodilator innervations along the vascular tree in this region.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>10460973</pmid><doi>10.1159/000016673</doi><tpages>10</tpages></addata></record> |
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| ispartof | Cells, tissues, organs, 1999-01, Vol.165 (1), p.45-54 |
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| source | MEDLINE; Karger_医学期刊; Alma/SFX Local Collection |
| subjects | Adult Antibodies Biopsy Calcitonin Gene-Related Peptide - analysis Calcitonin Gene-Related Peptide - immunology Elbow - blood supply Elbow - innervation Female Humans Male Middle Aged Muscle, Skeletal - blood supply Muscle, Skeletal - innervation Nerve Fibers - chemistry Nerve Fibers - enzymology Neurons, Afferent - pathology Neurons, Afferent - ultrastructure Neuropeptide Y - analysis Neuropeptide Y - immunology Original Paper Substance P - analysis Substance P - immunology Sympathetic Nervous System - anatomy & histology Sympathetic Nervous System - cytology Tendons - blood supply Tendons - innervation Tennis Elbow - pathology Thiolester Hydrolases - analysis Thiolester Hydrolases - immunology Tyrosine 3-Monooxygenase - analysis Tyrosine 3-Monooxygenase - immunology Ubiquitin Thiolesterase Vasoactive Intestinal Peptide - analysis Vasoactive Intestinal Peptide - immunology |
| title | Sympathetic and Sensory Innervations Are Heterogeneously Distributed in Relation to the Blood Vessels at the Extensor carpi radialis brevis Muscle Origin of Man |
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