Selective targeting of an antioxidant to mitochondria

Mitochondrial oxidative damage contributes significantly to a range of human disorders, including neurodegenerative diseases, ischaemia‐reperfusion injury and ageing‐associated dysfunction. To prevent this damage we have delivered a molecule containing the active antioxidant moiety of vitamin E to m...

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Veröffentlicht in:	European journal of biochemistry 1999-08, Vol.263 (3), p.709-716
Hauptverfasser:	Smith, Robin A. J., Porteous, Carolyn M., Coulter, Carolyn V., Murphy, Michael P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antioxidant Antioxidants - chemical synthesis Antioxidants - pharmacokinetics Antioxidants - pharmacology Benzopyrans - chemical synthesis Benzopyrans - pharmacokinetics Benzopyrans - pharmacology Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone - pharmacology Humans Intracellular Membranes - drug effects Intracellular Membranes - physiology Kinetics Lipid Peroxidation - drug effects Membrane Potentials mitochondria Mitochondria, Liver - drug effects Mitochondria, Liver - physiology Rats targeting Vitamin E - analogs & derivatives Vitamin E - chemical synthesis Vitamin E - pharmacokinetics Vitamin E - pharmacology vitamin E
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