Hepatitis G virus in multitransfused thalassaemics from India
Hepatitis G virus (HGV)/GB virus‐C (GBV‐C) has been identified as a blood‐borne agent with disputed pathogenicity. This virus belongs to the flaviviridae with a distant relationship to hepatitis C virus (HCV). Genetically divergent HGV isolates have been reported from different parts of the world. T...
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| Veröffentlicht in: | Journal of gastroenterology and hepatology 1998-09, Vol.13 (9), p.902-906 |
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| creator | PANIGRAHI, ASWINI K SAXENA, ALKA ACHARYA, SUBRAT K PANDA, SUBRAT K |
| description | Hepatitis G virus (HGV)/GB virus‐C (GBV‐C) has been identified as a blood‐borne agent with disputed pathogenicity. This virus belongs to the flaviviridae with a distant relationship to hepatitis C virus (HCV). Genetically divergent HGV isolates have been reported from different parts of the world. This study describes the prevalence of HGV in multitransfused thalassaemic children in India and genomic sequence variations in 11 HGV isolates from the same geographical location. Hepatitis G virus RNA was detected in 39.7% multitransfused thalassaemic children. The seroprevalence of hepatitis B virus (HBV) and HCV was 23.8% and 17.1%, respectively, and 11.4% had dual infection. The nucleotide sequence of a 166 bp HGV genomic segment from the putative capsid‐envelope region (nucleotide; nt 578–743) from 11 Indian isolates was compared to the sequences available in the nucleotide databases. The isolates from India were 81.3–94.5% homologous to the isolates from other parts of the world. On phylogenetic analysis, it was observed that HGV isolates from India may belong to two genetically divergent types. |
| doi_str_mv | 10.1111/j.1440-1746.1998.tb00759.x |
| format | Article |
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This virus belongs to the flaviviridae with a distant relationship to hepatitis C virus (HCV). Genetically divergent HGV isolates have been reported from different parts of the world. This study describes the prevalence of HGV in multitransfused thalassaemic children in India and genomic sequence variations in 11 HGV isolates from the same geographical location. Hepatitis G virus RNA was detected in 39.7% multitransfused thalassaemic children. The seroprevalence of hepatitis B virus (HBV) and HCV was 23.8% and 17.1%, respectively, and 11.4% had dual infection. The nucleotide sequence of a 166 bp HGV genomic segment from the putative capsid‐envelope region (nucleotide; nt 578–743) from 11 Indian isolates was compared to the sequences available in the nucleotide databases. The isolates from India were 81.3–94.5% homologous to the isolates from other parts of the world. On phylogenetic analysis, it was observed that HGV isolates from India may belong to two genetically divergent types.</description><identifier>ISSN: 0815-9319</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1111/j.1440-1746.1998.tb00759.x</identifier><identifier>PMID: 9794188</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Amino Acid Sequence ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis ; Child, Preschool ; Female ; Flaviviridae - classification ; Flaviviridae - isolation & purification ; genome ; hepatitis B virus ; hepatitis C virus ; hepatitis G virus ; Humans ; Infant ; Male ; Medical sciences ; Molecular Sequence Data ; phylogenetic analysis ; prevalence ; RNA, Viral - analysis ; thalassaemics ; Thalassemia - complications ; Thalassemia - therapy ; Transfusion Reaction ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Tropical medicine</subject><ispartof>Journal of gastroenterology and hepatology, 1998-09, Vol.13 (9), p.902-906</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4362-25dd045b4d4c2c75d51565a4345ca5c3a34c6dfa3bd7955e0d6c3c100fb54c0c3</citedby><cites>FETCH-LOGICAL-c4362-25dd045b4d4c2c75d51565a4345ca5c3a34c6dfa3bd7955e0d6c3c100fb54c0c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1440-1746.1998.tb00759.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1440-1746.1998.tb00759.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2389569$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9794188$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PANIGRAHI, ASWINI K</creatorcontrib><creatorcontrib>SAXENA, ALKA</creatorcontrib><creatorcontrib>ACHARYA, SUBRAT K</creatorcontrib><creatorcontrib>PANDA, SUBRAT K</creatorcontrib><title>Hepatitis G virus in multitransfused thalassaemics from India</title><title>Journal of gastroenterology and hepatology</title><addtitle>J Gastroenterol Hepatol</addtitle><description>Hepatitis G virus (HGV)/GB virus‐C (GBV‐C) has been identified as a blood‐borne agent with disputed pathogenicity. This virus belongs to the flaviviridae with a distant relationship to hepatitis C virus (HCV). Genetically divergent HGV isolates have been reported from different parts of the world. This study describes the prevalence of HGV in multitransfused thalassaemic children in India and genomic sequence variations in 11 HGV isolates from the same geographical location. Hepatitis G virus RNA was detected in 39.7% multitransfused thalassaemic children. The seroprevalence of hepatitis B virus (HBV) and HCV was 23.8% and 17.1%, respectively, and 11.4% had dual infection. The nucleotide sequence of a 166 bp HGV genomic segment from the putative capsid‐envelope region (nucleotide; nt 578–743) from 11 Indian isolates was compared to the sequences available in the nucleotide databases. The isolates from India were 81.3–94.5% homologous to the isolates from other parts of the world. On phylogenetic analysis, it was observed that HGV isolates from India may belong to two genetically divergent types.</description><subject>Amino Acid Sequence</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Flaviviridae - classification</subject><subject>Flaviviridae - isolation & purification</subject><subject>genome</subject><subject>hepatitis B virus</subject><subject>hepatitis C virus</subject><subject>hepatitis G virus</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>phylogenetic analysis</subject><subject>prevalence</subject><subject>RNA, Viral - analysis</subject><subject>thalassaemics</subject><subject>Thalassemia - complications</subject><subject>Thalassemia - therapy</subject><subject>Transfusion Reaction</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><subject>Tropical medicine</subject><issn>0815-9319</issn><issn>1440-1746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF1LwzAUhoMoOj9-glBEvGtNmqRtBAXZdFNEvVAEb0KapJjZbjOn1fnvzVjZvbkJ5H3Om-RB6ITghIR1Pk0IYzgmOcsSIkSRtCXGORfJcgsNNtE2GuCC8FhQIvbQPsAUY8wCt4t2RS4YKYoBupzYhWpd6yAaR9_OdxC5WdR0dTjzagZVB9ZE7YeqFYCyjdMQVX7eRHcz49Qh2qlUDfao3w_Q6-3Ny3ASPzyN74bXD7FmNEvjlBuDGS-ZYTrVOTec8IwrRhnXimuqKNOZqRQtTS44t9hkmmqCcVVyprGmB-hs3bvw86_OQisbB9rWtZrZeQcyDz-jomABvFiD2s8BvK3kwrtG-V9JsFy5k1O5EiRXguTKnezdyWUYPu5v6crGms1oLyvkp32uQKu6Cn60gw2W0kLwTATsao39uNr-_uMB8n48ETgNBfG6wEFrl5sC5T9lltOcy7fHsXwXAg9Ho2dJ6R8wbZpc</recordid><startdate>199809</startdate><enddate>199809</enddate><creator>PANIGRAHI, ASWINI K</creator><creator>SAXENA, ALKA</creator><creator>ACHARYA, SUBRAT K</creator><creator>PANDA, SUBRAT K</creator><general>Blackwell Publishing Ltd</general><general>Blackwell Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199809</creationdate><title>Hepatitis G virus in multitransfused thalassaemics from India</title><author>PANIGRAHI, ASWINI K ; SAXENA, ALKA ; ACHARYA, SUBRAT K ; PANDA, SUBRAT K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4362-25dd045b4d4c2c75d51565a4345ca5c3a34c6dfa3bd7955e0d6c3c100fb54c0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Amino Acid Sequence</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Flaviviridae - classification</topic><topic>Flaviviridae - isolation & purification</topic><topic>genome</topic><topic>hepatitis B virus</topic><topic>hepatitis C virus</topic><topic>hepatitis G virus</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>phylogenetic analysis</topic><topic>prevalence</topic><topic>RNA, Viral - analysis</topic><topic>thalassaemics</topic><topic>Thalassemia - complications</topic><topic>Thalassemia - therapy</topic><topic>Transfusion Reaction</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PANIGRAHI, ASWINI K</creatorcontrib><creatorcontrib>SAXENA, ALKA</creatorcontrib><creatorcontrib>ACHARYA, SUBRAT K</creatorcontrib><creatorcontrib>PANDA, SUBRAT K</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PANIGRAHI, ASWINI K</au><au>SAXENA, ALKA</au><au>ACHARYA, SUBRAT K</au><au>PANDA, SUBRAT K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatitis G virus in multitransfused thalassaemics from India</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><addtitle>J Gastroenterol Hepatol</addtitle><date>1998-09</date><risdate>1998</risdate><volume>13</volume><issue>9</issue><spage>902</spage><epage>906</epage><pages>902-906</pages><issn>0815-9319</issn><eissn>1440-1746</eissn><abstract>Hepatitis G virus (HGV)/GB virus‐C (GBV‐C) has been identified as a blood‐borne agent with disputed pathogenicity. This virus belongs to the flaviviridae with a distant relationship to hepatitis C virus (HCV). Genetically divergent HGV isolates have been reported from different parts of the world. This study describes the prevalence of HGV in multitransfused thalassaemic children in India and genomic sequence variations in 11 HGV isolates from the same geographical location. Hepatitis G virus RNA was detected in 39.7% multitransfused thalassaemic children. The seroprevalence of hepatitis B virus (HBV) and HCV was 23.8% and 17.1%, respectively, and 11.4% had dual infection. The nucleotide sequence of a 166 bp HGV genomic segment from the putative capsid‐envelope region (nucleotide; nt 578–743) from 11 Indian isolates was compared to the sequences available in the nucleotide databases. The isolates from India were 81.3–94.5% homologous to the isolates from other parts of the world. On phylogenetic analysis, it was observed that HGV isolates from India may belong to two genetically divergent types.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9794188</pmid><doi>10.1111/j.1440-1746.1998.tb00759.x</doi><tpages>5</tpages></addata></record> |
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| subjects | Amino Acid Sequence Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Child, Preschool Female Flaviviridae - classification Flaviviridae - isolation & purification genome hepatitis B virus hepatitis C virus hepatitis G virus Humans Infant Male Medical sciences Molecular Sequence Data phylogenetic analysis prevalence RNA, Viral - analysis thalassaemics Thalassemia - complications Thalassemia - therapy Transfusion Reaction Transfusions. Complications. Transfusion reactions. Cell and gene therapy Tropical medicine |
| title | Hepatitis G virus in multitransfused thalassaemics from India |
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