Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation

CD39, or vascular adenosine triphosphate diphosphohydrolase, has been considered an important inhibitor of platelet activation. Unexpectedly, cd39 -deficient mice had prolonged bleeding times with minimally perturbed coagulation parameters. Platelet interactions with injured mesenteric vasculature w...

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Veröffentlicht in:	Nature medicine 1999-09, Vol.5 (9), p.1010-1017
Hauptverfasser:	Enjyoji, Keiichi, Sévigny, Jean, Lin, Yuan, Frenette, Paul S., Christie, Patricia D., Esch, Jan Schulte Am, Imai, Masato, Edelberg, Jay M., Rayburn, Helen, Lech, Miroslaw, Beeler, David L., Csizmadia, Eva, Wagner, Denisa D., Robson, Simon C., Rosenberg, Robert D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases Animals Antigens, CD - genetics Antigens, CD - metabolism Apyrase - deficiency Apyrase - genetics Apyrase - metabolism Arterioles - pathology Biomedical and Life Sciences Biomedicine Bleeding Time Blood Coagulation Blood Platelets - cytology Blood Platelets - pathology Blood Platelets - physiology Cancer Research Cells, Cultured Endothelium, Vascular - cytology Endothelium, Vascular - enzymology Endothelium, Vascular - metabolism Female Fibrin - metabolism Gene Deletion Graft Rejection - immunology Graft Rejection - pathology Heart Transplantation - immunology Heart Transplantation - pathology Hemostasis Infectious Diseases Male Mesentery - blood supply Metabolic Diseases Mice Mice, Knockout Molecular Medicine Neurosciences Platelet Aggregation Rats Receptors, Purinergic P2 - physiology Receptors, Purinergic P2Y1 Thromboplastin - metabolism Thrombosis - pathology
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