Comparison of urinary free beta (hCG) and beta-core (hCG) in prenatal screening for chromosomal abnormalities
To evaluate the potential utility of free beta (hCG) and beta‐core (hCG) in a prenatal screening protocol for Down syndrome we analysed these markers in dried maternal urine specimens from 163 control, 13 Down syndrome and 5 trisomy 18 pregnancies from 8 to 25 weeks' gestation. All results are...
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| Veröffentlicht in: | Prenatal diagnosis 1998-09, Vol.18 (9), p.893-900 |
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| creator | Hallahan, Terrence W. Krantz, David A. Tului, Lucia Alberti, Ezio Buchanan, Philip D. Orlandi, Francesco Klein, Victor Larsen Jr, John W. Macri, James N. |
| description | To evaluate the potential utility of free beta (hCG) and beta‐core (hCG) in a prenatal screening protocol for Down syndrome we analysed these markers in dried maternal urine specimens from 163 control, 13 Down syndrome and 5 trisomy 18 pregnancies from 8 to 25 weeks' gestation. All results are reported after normalization for urinary creatinine determined by modified Jaffe reagent assay. The correlation of urinary free beta (hCG) and urinary beta‐core (hCG) was 0·61 in controls and 0·93 in Down syndrome. Median MoM values in Down syndrome were 2·42 for urinary free beta (hCG) and 2·40 for beta‐core (hCG). In trisomy 18 the median MoM was 0·35 and 0·34 for free beta (hCG) and beta‐core (hCG), respectively. The degree of elevation observed in DS cases with urinary free beta (hCG) is consistent with previous reports. Studies of beta‐core (hCG) in Down syndrome have yielded discrepant results. In this study, beta‐core (hCG) in Down syndrome is lower than values observed in early reports but consistent with more recent reports. © 1998 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/(SICI)1097-0223(199809)18:9<893::AID-PD362>3.0.CO;2-E |
| format | Article |
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All results are reported after normalization for urinary creatinine determined by modified Jaffe reagent assay. The correlation of urinary free beta (hCG) and urinary beta‐core (hCG) was 0·61 in controls and 0·93 in Down syndrome. Median MoM values in Down syndrome were 2·42 for urinary free beta (hCG) and 2·40 for beta‐core (hCG). In trisomy 18 the median MoM was 0·35 and 0·34 for free beta (hCG) and beta‐core (hCG), respectively. The degree of elevation observed in DS cases with urinary free beta (hCG) is consistent with previous reports. Studies of beta‐core (hCG) in Down syndrome have yielded discrepant results. In this study, beta‐core (hCG) in Down syndrome is lower than values observed in early reports but consistent with more recent reports. © 1998 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0197-3851</identifier><identifier>EISSN: 1097-0223</identifier><identifier>DOI: 10.1002/(SICI)1097-0223(199809)18:9<893::AID-PD362>3.0.CO;2-E</identifier><identifier>PMID: 9793970</identifier><identifier>CODEN: PRDIDM</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>beta-core (hCG) ; Biological and medical sciences ; Chorionic Gonadotropin, beta Subunit, Human - urine ; Chromosome Aberrations ; Chromosomes, Human, Pair 18 ; Down Syndrome - diagnosis ; Down syndrome screening ; False Positive Reactions ; Female ; free beta (hCG) ; Gestational Age ; Gynecology. Andrology. Obstetrics ; Humans ; Management. Prenatal diagnosis ; maternal urine ; Medical sciences ; Pregnancy ; Pregnancy. Fetus. Placenta ; Prenatal Diagnosis - methods ; Reference Values ; Trisomy</subject><ispartof>Prenatal diagnosis, 1998-09, Vol.18 (9), p.893-900</ispartof><rights>Copyright © 1998 John Wiley & Sons, Ltd.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291097-0223%28199809%2918%3A9%3C893%3A%3AAID-PD362%3E3.0.CO%3B2-E$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291097-0223%28199809%2918%3A9%3C893%3A%3AAID-PD362%3E3.0.CO%3B2-E$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2396173$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9793970$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hallahan, Terrence W.</creatorcontrib><creatorcontrib>Krantz, David A.</creatorcontrib><creatorcontrib>Tului, Lucia</creatorcontrib><creatorcontrib>Alberti, Ezio</creatorcontrib><creatorcontrib>Buchanan, Philip D.</creatorcontrib><creatorcontrib>Orlandi, Francesco</creatorcontrib><creatorcontrib>Klein, Victor</creatorcontrib><creatorcontrib>Larsen Jr, John W.</creatorcontrib><creatorcontrib>Macri, James N.</creatorcontrib><title>Comparison of urinary free beta (hCG) and beta-core (hCG) in prenatal screening for chromosomal abnormalities</title><title>Prenatal diagnosis</title><addtitle>Prenat. Diagn</addtitle><description>To evaluate the potential utility of free beta (hCG) and beta‐core (hCG) in a prenatal screening protocol for Down syndrome we analysed these markers in dried maternal urine specimens from 163 control, 13 Down syndrome and 5 trisomy 18 pregnancies from 8 to 25 weeks' gestation. All results are reported after normalization for urinary creatinine determined by modified Jaffe reagent assay. The correlation of urinary free beta (hCG) and urinary beta‐core (hCG) was 0·61 in controls and 0·93 in Down syndrome. Median MoM values in Down syndrome were 2·42 for urinary free beta (hCG) and 2·40 for beta‐core (hCG). In trisomy 18 the median MoM was 0·35 and 0·34 for free beta (hCG) and beta‐core (hCG), respectively. The degree of elevation observed in DS cases with urinary free beta (hCG) is consistent with previous reports. Studies of beta‐core (hCG) in Down syndrome have yielded discrepant results. In this study, beta‐core (hCG) in Down syndrome is lower than values observed in early reports but consistent with more recent reports. © 1998 John Wiley & Sons, Ltd.</description><subject>beta-core (hCG)</subject><subject>Biological and medical sciences</subject><subject>Chorionic Gonadotropin, beta Subunit, Human - urine</subject><subject>Chromosome Aberrations</subject><subject>Chromosomes, Human, Pair 18</subject><subject>Down Syndrome - diagnosis</subject><subject>Down syndrome screening</subject><subject>False Positive Reactions</subject><subject>Female</subject><subject>free beta (hCG)</subject><subject>Gestational Age</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Management. Prenatal diagnosis</subject><subject>maternal urine</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Prenatal Diagnosis - methods</subject><subject>Reference Values</subject><subject>Trisomy</subject><issn>0197-3851</issn><issn>1097-0223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuP0zAUhS0EGsrAT0DKAqF2keJHE8flIQ2ZTimqpki8lleuc8MYkrjYqWD-Pe6k6gYkVr6-j09H5xDymtEpo5S_GH9clasJo0qmlHMxZkoVVE1YMVevCiXm84vVZfrhUuT8jZjSabl5ydPFPTI6XdwnI8piLYqMPSSPQvgesQVX8oycKamEknRE2tK1O-1tcF3i6mTvbaf9bVJ7xGSLvU7GN-Vykuiuuvumxnk89myX7Dx2utdNEkw86Gz3LamdT8yNd60Lro0Tve2cj4XtLYbH5EGtm4BPju85-Xy1-FS-S9eb5aq8WKdmJihPNRY8Q6lYVkmGWzPLtMkzVYntTFSsZhK5NhqxyqsMtc5RSjQ1M4XkIs-NEufk-cDdefdzj6GH1gaDTaM7dPsAklIqmJyJkwDjXQgea9h520YHgFE4xABwiAEOpsLBVBhiAFaAghgDQIwB7mIAARTKDXBYRO7To4D9tsXqRD36HufPjnMdjG5qrztjw2mNC5UzKeLal2Htl23w9i9t_5H2L2VDI4LTAWxDj79PYO1_QC6FzODr9RKu3pdrns-u4a34A6uJvrg</recordid><startdate>199809</startdate><enddate>199809</enddate><creator>Hallahan, Terrence W.</creator><creator>Krantz, David A.</creator><creator>Tului, Lucia</creator><creator>Alberti, Ezio</creator><creator>Buchanan, Philip D.</creator><creator>Orlandi, Francesco</creator><creator>Klein, Victor</creator><creator>Larsen Jr, John W.</creator><creator>Macri, James N.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199809</creationdate><title>Comparison of urinary free beta (hCG) and beta-core (hCG) in prenatal screening for chromosomal abnormalities</title><author>Hallahan, Terrence W. ; Krantz, David A. ; Tului, Lucia ; Alberti, Ezio ; Buchanan, Philip D. ; Orlandi, Francesco ; Klein, Victor ; Larsen Jr, John W. ; Macri, James N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4302-ae825e7915d71ebc45ac659d3b43d1f17e2acaeed6d5eaa6e77ecf1c872366c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>beta-core (hCG)</topic><topic>Biological and medical sciences</topic><topic>Chorionic Gonadotropin, beta Subunit, Human - urine</topic><topic>Chromosome Aberrations</topic><topic>Chromosomes, Human, Pair 18</topic><topic>Down Syndrome - diagnosis</topic><topic>Down syndrome screening</topic><topic>False Positive Reactions</topic><topic>Female</topic><topic>free beta (hCG)</topic><topic>Gestational Age</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Management. Prenatal diagnosis</topic><topic>maternal urine</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Prenatal Diagnosis - methods</topic><topic>Reference Values</topic><topic>Trisomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hallahan, Terrence W.</creatorcontrib><creatorcontrib>Krantz, David A.</creatorcontrib><creatorcontrib>Tului, Lucia</creatorcontrib><creatorcontrib>Alberti, Ezio</creatorcontrib><creatorcontrib>Buchanan, Philip D.</creatorcontrib><creatorcontrib>Orlandi, Francesco</creatorcontrib><creatorcontrib>Klein, Victor</creatorcontrib><creatorcontrib>Larsen Jr, John W.</creatorcontrib><creatorcontrib>Macri, James N.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Prenatal diagnosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hallahan, Terrence W.</au><au>Krantz, David A.</au><au>Tului, Lucia</au><au>Alberti, Ezio</au><au>Buchanan, Philip D.</au><au>Orlandi, Francesco</au><au>Klein, Victor</au><au>Larsen Jr, John W.</au><au>Macri, James N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of urinary free beta (hCG) and beta-core (hCG) in prenatal screening for chromosomal abnormalities</atitle><jtitle>Prenatal diagnosis</jtitle><addtitle>Prenat. Diagn</addtitle><date>1998-09</date><risdate>1998</risdate><volume>18</volume><issue>9</issue><spage>893</spage><epage>900</epage><pages>893-900</pages><issn>0197-3851</issn><eissn>1097-0223</eissn><coden>PRDIDM</coden><abstract>To evaluate the potential utility of free beta (hCG) and beta‐core (hCG) in a prenatal screening protocol for Down syndrome we analysed these markers in dried maternal urine specimens from 163 control, 13 Down syndrome and 5 trisomy 18 pregnancies from 8 to 25 weeks' gestation. All results are reported after normalization for urinary creatinine determined by modified Jaffe reagent assay. The correlation of urinary free beta (hCG) and urinary beta‐core (hCG) was 0·61 in controls and 0·93 in Down syndrome. Median MoM values in Down syndrome were 2·42 for urinary free beta (hCG) and 2·40 for beta‐core (hCG). In trisomy 18 the median MoM was 0·35 and 0·34 for free beta (hCG) and beta‐core (hCG), respectively. The degree of elevation observed in DS cases with urinary free beta (hCG) is consistent with previous reports. Studies of beta‐core (hCG) in Down syndrome have yielded discrepant results. In this study, beta‐core (hCG) in Down syndrome is lower than values observed in early reports but consistent with more recent reports. © 1998 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>9793970</pmid><doi>10.1002/(SICI)1097-0223(199809)18:9<893::AID-PD362>3.0.CO;2-E</doi><tpages>8</tpages></addata></record> |
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| subjects | beta-core (hCG) Biological and medical sciences Chorionic Gonadotropin, beta Subunit, Human - urine Chromosome Aberrations Chromosomes, Human, Pair 18 Down Syndrome - diagnosis Down syndrome screening False Positive Reactions Female free beta (hCG) Gestational Age Gynecology. Andrology. Obstetrics Humans Management. Prenatal diagnosis maternal urine Medical sciences Pregnancy Pregnancy. Fetus. Placenta Prenatal Diagnosis - methods Reference Values Trisomy |
| title | Comparison of urinary free beta (hCG) and beta-core (hCG) in prenatal screening for chromosomal abnormalities |
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