Long-term follow-up of patients enrolled in a randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small-cell lung cancer
Our previously reported randomized study of patients with untreated, potentially resectable clinical stage IIIA non-small-cell lung cancer found that patients treated with perioperative chemotherapy and surgery had a significant increase in median survival compared to patients treated with surgery a...
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| Veröffentlicht in: | Lung cancer (Amsterdam, Netherlands) Netherlands), 1998-07, Vol.21 (1), p.1-6 |
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| container_title | Lung cancer (Amsterdam, Netherlands) |
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| creator | Roth, Jack A Atkinson, E.Neely Fossella, Frank Komaki, Ritsuko Ryan, M.Bernadette Putnam, J.B Lee, Jin Soo Dhingra, Hari De Caro, Louis Chasen, Marvin Hong, Waun Ki |
| description | Our previously reported randomized study of patients with untreated, potentially resectable clinical stage IIIA non-small-cell lung cancer found that patients treated with perioperative chemotherapy and surgery had a significant increase in median survival compared to patients treated with surgery alone. We have now re-analyzed the results of the study with a median time from random allocation to analysis for all patients of 82 months. The increase in survival conferred by perioperative chemotherapy was maintained during the period of extended observation. |
| doi_str_mv | 10.1016/S0169-5002(98)00046-4 |
| format | Article |
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The increase in survival conferred by perioperative chemotherapy was maintained during the period of extended observation.</description><identifier>ISSN: 0169-5002</identifier><identifier>EISSN: 1872-8332</identifier><identifier>DOI: 10.1016/S0169-5002(98)00046-4</identifier><identifier>PMID: 9792048</identifier><identifier>CODEN: LUCAE5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Antineoplastic Agents - therapeutic use ; Biological and medical sciences ; Carcinoma, Non-Small-Cell Lung - drug therapy ; Carcinoma, Non-Small-Cell Lung - surgery ; Chemotherapy, Adjuvant ; Cisplatin ; Disease-Free Survival ; Female ; Follow-Up Studies ; Humans ; Induction chemotherapy ; Lung cancer ; Lung Neoplasms - drug therapy ; Lung Neoplasms - surgery ; Male ; Medical sciences ; Middle Aged ; Randomized trial ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the respiratory system ; Survival Analysis ; Treatment Outcome</subject><ispartof>Lung cancer (Amsterdam, Netherlands), 1998-07, Vol.21 (1), p.1-6</ispartof><rights>1998 Elsevier Science Ireland Ltd</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-10b8df202bcfbcf61cf0659dbd40bee3ce61ec306f769fe7925a2f88b2294acf3</citedby><cites>FETCH-LOGICAL-c389t-10b8df202bcfbcf61cf0659dbd40bee3ce61ec306f769fe7925a2f88b2294acf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0169500298000464$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2410741$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9792048$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roth, Jack A</creatorcontrib><creatorcontrib>Atkinson, E.Neely</creatorcontrib><creatorcontrib>Fossella, Frank</creatorcontrib><creatorcontrib>Komaki, Ritsuko</creatorcontrib><creatorcontrib>Ryan, M.Bernadette</creatorcontrib><creatorcontrib>Putnam, J.B</creatorcontrib><creatorcontrib>Lee, Jin Soo</creatorcontrib><creatorcontrib>Dhingra, Hari</creatorcontrib><creatorcontrib>De Caro, Louis</creatorcontrib><creatorcontrib>Chasen, Marvin</creatorcontrib><creatorcontrib>Hong, Waun Ki</creatorcontrib><title>Long-term follow-up of patients enrolled in a randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small-cell lung cancer</title><title>Lung cancer (Amsterdam, Netherlands)</title><addtitle>Lung Cancer</addtitle><description>Our previously reported randomized study of patients with untreated, potentially resectable clinical stage IIIA non-small-cell lung cancer found that patients treated with perioperative chemotherapy and surgery had a significant increase in median survival compared to patients treated with surgery alone. 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The increase in survival conferred by perioperative chemotherapy was maintained during the period of extended observation.</description><subject>Antineoplastic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Non-Small-Cell Lung - drug therapy</subject><subject>Carcinoma, Non-Small-Cell Lung - surgery</subject><subject>Chemotherapy, Adjuvant</subject><subject>Cisplatin</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Induction chemotherapy</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - drug therapy</subject><subject>Lung Neoplasms - surgery</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Randomized trial</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. 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| ispartof | Lung cancer (Amsterdam, Netherlands), 1998-07, Vol.21 (1), p.1-6 |
| issn | 0169-5002 1872-8332 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antineoplastic Agents - therapeutic use Biological and medical sciences Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - surgery Chemotherapy, Adjuvant Cisplatin Disease-Free Survival Female Follow-Up Studies Humans Induction chemotherapy Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - surgery Male Medical sciences Middle Aged Randomized trial Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the respiratory system Survival Analysis Treatment Outcome |
| title | Long-term follow-up of patients enrolled in a randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small-cell lung cancer |
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